Subretinal Neovascular Membrane in an Infant With a Retinochoroidal Coloboma

Chorioretinal coloboma complications: retinal detachment and choroidal neovascular membrane

“…Laser photocoagulation is the most frequently used method reported in the literature and has consistently resulted in regression of the CNV and improvement of visual acuity in these cases. [ 24 25 26 27 28 29 ] It is generally avoided in cases of juxtafoveal or subfoveal CNV due to the high risk of iatrogenic vision loss.…”

Chorioretinal coloboma complications: retinal detachment and choroidal neovascular membrane

“…Laser photocoagulation is the most frequently used method reported in the literature and has consistently resulted in regression of the CNV and improvement of visual acuity in these cases. [ 24 25 26 27 28 29 ] It is generally avoided in cases of juxtafoveal or subfoveal CNV due to the high risk of iatrogenic vision loss.…”

Intravitreal bevacizumab in choroidal neovascularization associated with congenital choroidal and optic nerve coloboma in children: Long-term improvement in visual acuity

“…1 The margin of the coloboma holds important information related to pathogenesis of choroidal neovascularization in these patients. Recent optical coherence tomography-based reports have shown either an abrupt or gradual transition of the inner retinal layers into the intercalary membrane along with absence of the outer retinal layers and retinal pigment epithelium at the coloboma margin.…”

Caspase-3 in Postnatal Retinal Development and Degeneration

“…14 They are characterized by folding of the perioptic retina and posterior coloboma involving retinal pigment epithelium, sclera, or choroid. Subretinal neovascularization can be associated with retinochoroidal colobomas, 21,22 suggesting that vascular penetration of the choroid will occur if the subretinal space is unprotected by intact RPE. This the most likely cause of abnormal localization of the neuroretina in the choroidal stroma in caspase-3 Ϫ/Ϫ mice, but has not been described in humans.…”

Chorioretinal coloboma complications: retinal detachment and choroidal neovascular membrane

“…Laser photocoagulation is the most frequently used method reported in the literature and has consistently resulted in regression of the CNV and improvement of visual acuity in these cases. [ 24 25 26 27 28 29 ] It is generally avoided in cases of juxtafoveal or subfoveal CNV due to the high risk of iatrogenic vision loss.…”

Intravitreal bevacizumab in choroidal neovascularization associated with congenital choroidal and optic nerve coloboma in children: Long-term improvement in visual acuity

“…1 The margin of the coloboma holds important information related to pathogenesis of choroidal neovascularization in these patients. Recent optical coherence tomography-based reports have shown either an abrupt or gradual transition of the inner retinal layers into the intercalary membrane along with absence of the outer retinal layers and retinal pigment epithelium at the coloboma margin.…”

Caspase-3 in Postnatal Retinal Development and Degeneration

“…14 They are characterized by folding of the perioptic retina and posterior coloboma involving retinal pigment epithelium, sclera, or choroid. Subretinal neovascularization can be associated with retinochoroidal colobomas, 21,22 suggesting that vascular penetration of the choroid will occur if the subretinal space is unprotected by intact RPE. This the most likely cause of abnormal localization of the neuroretina in the choroidal stroma in caspase-3 Ϫ/Ϫ mice, but has not been described in humans.…”

Chorioretinal coloboma complications: retinal detachment and choroidal neovascular membrane

“…Laser photocoagulation is the most frequently used method reported in the literature and has consistently resulted in regression of the CNV and improvement of visual acuity in these cases. [ 24 25 26 27 28 29 ] It is generally avoided in cases of juxtafoveal or subfoveal CNV due to the high risk of iatrogenic vision loss.…”

Intravitreal bevacizumab in choroidal neovascularization associated with congenital choroidal and optic nerve coloboma in children: Long-term improvement in visual acuity

“…1 The margin of the coloboma holds important information related to pathogenesis of choroidal neovascularization in these patients. Recent optical coherence tomography-based reports have shown either an abrupt or gradual transition of the inner retinal layers into the intercalary membrane along with absence of the outer retinal layers and retinal pigment epithelium at the coloboma margin.…”

Caspase-3 in Postnatal Retinal Development and Degeneration

“…14 They are characterized by folding of the perioptic retina and posterior coloboma involving retinal pigment epithelium, sclera, or choroid. Subretinal neovascularization can be associated with retinochoroidal colobomas, 21,22 suggesting that vascular penetration of the choroid will occur if the subretinal space is unprotected by intact RPE. This the most likely cause of abnormal localization of the neuroretina in the choroidal stroma in caspase-3 Ϫ/Ϫ mice, but has not been described in humans.…”