2011
DOI: 10.1111/j.1369-1600.2011.00325.x View full text |Buy / Rent full text
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Abstract: The functional integrity of the nucleus accumbens (NAC) core and shell is necessary for contextual cocaine-seeking behavior in the reinstatement animal model of drug relapse; however, the neuropharmacological mechanisms underlying this phenomenon are poorly understood. The present study evaluated the contribution of metabotropic glutamate receptor subtype 1 (mGluR1) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor populations to drug context-induced reinstatement of cocaine-seek… Show more

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“…Furthermore, this phenomenon likely involves glutamatergic afferents from the BLA (Fuchs et al, 2005(Fuchs et al, , 2004Lasseter et al, 2009Lasseter et al, , 2011. Interestingly, the training protocol used in the present study fails to elicit significant context-induced reinstatement of food-seeking behavior, as shown previously (Xie et al, 2010). Thus, contextual conditioning with natural reinforcers may be less robust due to overshadowing by explicit food-related/conditioned stimuli or qualitatively different due to background conditioning, relative to contextual conditioning with intravenous drug reinforcers.…”
Section: Discussioncontrasting
“…Within this system, the OFC and BLA are well-positioned to integrate contextrelevant multi-modal sensory input from sensory cortices with reward-related information from other mesocorticolimbic brain regions in order to guide goal-directed behaviors (Brog et al, 1993;Carmichael and Price, 1995b;Fuchs et al, 2008;McDannald et al, 2004;Price, 1986;Sah et al, 2003;Xie et al, 2010). For instance, in addition to dopaminergic input from the VTA to the OFC and BLA, glutamatergic inputs from the OFC and BLA and dopaminergic input from the VTA converge on dendritic spines of nucleus accumbens (NAc) medium spiny neurons (Kelley et al, 1982;Bouyer et al, 1984;Haber et al, 1995).…”
Section: Discussionmentioning
“…Similar to our findings, nicotine-seeking behavior induced by nicotine priming and nicotine-associated cues was attenuated by selective antagonism of mGluR1 in rats (Dravolina et al, 2007). Xie et al (2010Xie et al ( , 2012 also found that blocking mGluR1 activity in the dorsal hippocampus or the nucleus accumbens core inhibited context-induced reinstatement of cocaine seeking. Our results are therefore consistent with recent reports that mGluR1 signaling might play a role in specific neural networks to mediate reactivity to cocaine-associated cues and subsequent relapse to cocaine seeking.…”
supporting
“…Regarding psychostimulants, the inhibition of mGluR1 activity blocked cocaineinduced psychomotor sensitization (Dravolina et al, 2006;Kotlinska and Bochenski, 2011) and methamphetamine-induced hyperlocomotion (Satow et al, 2008), and amphetamine-induced locomotor activity was greater in mGluR1 knockout mice compared with their wild-type littermates (Mao et al, 2001). In reinstatement studies, cue-induced reinstatement of cocaine seeking (Xie et al, 2010(Xie et al, , 2012 and nicotine-induced reinstatement of nicotine seeking (Dravolina et al, 2007) were also attenuated by mGluR1 antagonists. In addition, emerging evidence at the molecular level implicates mGluR1 in the regulation of cocaine's long-term effects because it has been shown that the pharmacological manipulation of mGluR1 activity can alter cocaine-induced trafficking of the ␣-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (McCutcheon et al, 2011), which are ligand-gated ionotropic glutamatergic receptors critical for cocaine-induced synaptic plasticity (Tzschentke and Schmidt, 2003).…”
Section: Introductionmentioning
“…Although the role of the lateral shell has been relatively less understood in addiction processes, a recent study shows that blocking the AMPAR in either the NAcore or medial or lateral NAshell similarly impairs context-induced reinstatement of cocaine seeking (Xie et al, 2012) 2. Dopaminergic Afferents.…”
Section: B Nucleus Accumbens Shellmentioning