Sublingual Lorazepam in Childhood Serial Seizures

A Comparison of Rectal Diazepam Gel and Placebo for Acute Repetitive Seizures

“…7 Oral diazepam and lorazepam, sublingual lorazepam, rectal solutions of lorazepam and diazepam, and diazepam suppositories have been used to treat acute repetitive seizures. [8][9][10][11][12][13] Oral or sublingual administration is frequently difficult and hazardous when the patient is actively convulsing, and absorption of diazepam and lorazepam tablets and rectal lorazepam solution is slower than that of rectal diazepam solutions. 8,14,15 Rectal diazepam solutions have many characteristics sought in the ideal drug to treat acute repetitive seizures.…”

Clinical pharmacology of lorazepam in infants and children

“…The mean elimination half-life is 23.7 hours following intravenous dosing and 36.9 hours following intramuscular dosing [24] suggesting that lorazepam is slowly eliminated following intramuscular administration because lorazepam slowly leaves from the muscle depot. The treatment with lorazepam in infants and children has been extensively studied [25][26][27][28][29][30][31][32][33].…”

“…Lorazepam is an effective and safe agent to treat the status epilepticus in children [31], sublingual lorazepam easily and effectively controls serial seizures in children [32], and the convulsions are controlled in 76% of children treated with single rectal lorazepam and in 51% children treated with single rectal diazepam [33]. The trials with lorazepam have studied in children [34][35][36][37][38].…”

Buccal Clonazepam versus Intravenous (I/V) Midazolam for Management of Acute Breakthrough Seizure –A Randomized Controlled Trial

“…However during a convulsion risk for aspiration is serious .The sublingual route is difficult in a tightly clenched jaw during the tonic phase of the seizure [24].…”