Sublethal effects in Atlantic salmon (Salmo salar) exposed to mixtures of copper, aluminium and gamma radiation

Heier, Lene Sørlie; Teien, Hans Christian; Oughton, Deborah; Tollefsen, Knut-Erik; Rosseland, Bjørn Olav; Lind, Ole Christian; Farmen, Eivind; Skipperud, Lindis; Salbu, Brit

doi:10.1016/j.jenvrad.2012.04.004

Cited by 17 publications

(14 citation statements)

References 47 publications

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“…However, Alam and Maughan (1992) evaluated, on the common carp (Cyprinus carpio), a lethal concentration for iron (LC 50 96 h) between 0.56 and 2.25 mg/L (concentrations similar to those found in our ponds). Heier et al (2013) showed that copper and aluminum accumulate more in mixtures than alone, and Qu et al (2014) reported the same thing for a freshwater fish (Carassius auratus) when zinc was added to different metals (iron and copper). Finally, differences in the response to metal contamination observed in our study compared to others may be due to the choice of fish species.…”

Section: Polymetallic Contaminationmentioning

confidence: 86%

“…Several other studies reported no induction by trace metals of the antioxidant system (Eyckmans et al 2011;Heier et al 2013;Kelly and Janz 2009;Marques et al 2013). However, many other reports mentioned antioxidant system alterations caused by exposure to trace metals (Barillet et al 2011;Fernandez-Davila et al 2012;Heier et al 2013;Maria et al 2009;Oliva et al 2012a;Qu et al 2014;Sanchez et al 2007) or stimulations of some of these proteins and enzymes (Andersen et al 1998;Eyckmans et al 2011;Fernandez-Davila et al 2012;Kelly and Janz 2009;Vieira et al 2012). Effects of metals on fish antioxidant responses depended on the dose, the route of exposure and the lag time between the start of exposure and antioxidant system analyses.…”

Section: Effects On Biologic Parametersmentioning

confidence: 89%

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In situ effects of metal contamination from former uranium mining sites on the health of the three-spined stickleback (Gasterosteus aculeatus, L.)

et al. 2016

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Human activities have led to increased levels of various pollutants including metals in aquatic ecosystems. Increase of metallic concentrations in aquatic environments represents a potential risk to exposed organisms, including fish. The aim of this study was to characterize the environmental risk to fish health linked to a polymetallic contamination from former uranium mines in France. This contamination is characterized by metals naturally present in the areas (manganese and iron), uranium, and metals (aluminum and barium) added to precipitate uranium and its decay products. Effects from mine releases in two contaminated ponds (Pontabrier for Haute-Vienne Department and Saint-Pierre for Cantal Department) were compared to those assessed at four other ponds outside the influence of mine tailings (two reference ponds/department). In this way, 360 adult three-spined sticklebacks (Gasterosteus aculeatus) were caged for 28 days in these six ponds before biomarker analyses (immune system, antioxidant system, biometry, histology, DNA integrity, etc.). Ponds receiving uranium mine tailings presented higher concentrations of uranium, manganese and aluminum, especially for the Haute-Vienne Department. This uranium contamination could explain the higher bioaccumulation of this metal in fish caged in Pontabrier and Saint-Pierre Ponds. In the same way, many fish biomarkers (antioxidant and immune systems, acetylcholinesterase activity and biometric parameters) were impacted by this environmental exposure to mine tailings. This study shows the interest of caging and the use of a multi-biomarker approach in the study of a complex metallic contamination.

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Section: Polymetallic Contaminationmentioning

confidence: 86%

Section: Effects On Biologic Parametersmentioning

confidence: 89%

In situ effects of metal contamination from former uranium mining sites on the health of the three-spined stickleback (Gasterosteus aculeatus, L.)

et al. 2016

View full text Add to dashboard Cite

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“…For the protection against ROS, organisms can set up their antioxidant system. This system includes several enzymes, proteins and peptides produced by the liver, and their aim is to neutralize ROS (Eyckmans et al 2011;Heier et al 2013;Kelly and Janz 2009;Sanchez et al 2005). The antioxidant system may also be altered by pollutants and in particular metals (Fernandez-Davila et al 2012;Oliva et al 2012;Qu et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Acclimation capacity of the three-spined stickleback (Gasterosteus aculeatus, L.) to a sudden biological stress following a polymetallic exposure

et al. 2016

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To get closer to the environmental reality, ecotoxicological studies should no longer consider the evaluation of a single pollutant, but rather combination of stress and their interaction. The aim of this study was to determine if responses of a fish to a sudden biological stress could be modified by a prior exposure to a chemical stress (a polymetallic contamination). For this purpose, in situ experiment was conducted in three ponds in the Haute-Vienne department (France). One pond was chosen for its high uranium concentration due to uranium mine tailings, and the two other ponds, which were not submitted to these tailings. Three-spined sticklebacks (Gasterosteus aculeatus) were caged in these ponds for 14 days. After this period, fish were submitted to a biological stress, exerted by lipopolysaccharides injection after anesthesia, and were sacrificed 4 days after these injections for multi-biomarkers analyses (leucocyte viability, phagocytic capacity and reactive oxygen species production, antioxidant peptide and enzymes, lipid peroxidation and DNA damage). The pond which received uranium mine tailings had higher metallic concentrations. Without biological stress, sticklebacks caged in this pond presented an oxidative stress, with increasing of reactive oxygen species levels, modification of some parts of the antioxidant system, and lipid peroxidation. Caging in the two most metal-contaminated ponds resulted in an increase of susceptibility of sticklebacks to the biological stress, preventing their phagocytic responses to lipopolysaccharides and modifying their glutathione contents and glutathione-S-transferase activity.

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“…In reality, it is inevitable that living organisms are subjected to various environmental stressors collectively, with the resultant effects being referred to as multiple stressor effects, and the assessment on the probability and seriousness of the resultant effects is referred to as cumulative risk assessment [1]. For realistic cumulative risk assessments, therefore, thorough understanding on the multiple stressor effects is indispensable [2][3][4][5][6][7][8]. As such, when discussing the effects of airborne contaminants on human beings, the effects from collective exposures to all significant airborne contaminants (e.g., ionizing radiation, chemicals, cigarette smoke, heavy metals, etc.)…”

Section: Introduction To Multiple Stressor Effectmentioning

confidence: 99%

Multiple Stressor Effects of Radon and Phthalates in Children: Background Information and Future Research

Kwan

Nikezić

Roy

et al. 2020

IJERPH

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The present paper reviews available background information for studying multiple stressor effects of radon (222Rn) and phthalates in children and provides insights on future directions. In realistic situations, living organisms are collectively subjected to many environmental stressors, with the resultant effects being referred to as multiple stressor effects. Radon is a naturally occurring radioactive gas that can lead to lung cancers. On the other hand, phthalates are semi-volatile organic compounds widely applied as plasticizers to provide flexibility to plastic in consumer products. Links of phthalates to various health effects have been reported, including allergy and asthma. In the present review, the focus on indoor contaminants was due to their higher concentrations and to the higher indoor occupancy factor, while the focus on the pediatric population was due to their inherent sensitivity and their spending more time close to the floor. Two main future directions in studying multiple stressor effects of radon and phthalates in children were proposed. The first one was on computational modeling and micro-dosimetric studies, and the second one was on biological studies. In particular, dose-response relationship and effect-specific models for combined exposures to radon and phthalates would be necessary. The ideas and methodology behind such proposed research work are also applicable to studies on multiple stressor effects of collective exposures to other significant airborne contaminants, and to population groups other than children.

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Sublethal effects in Atlantic salmon (Salmo salar) exposed to mixtures of copper, aluminium and gamma radiation

Cited by 17 publications

References 47 publications

In situ effects of metal contamination from former uranium mining sites on the health of the three-spined stickleback (Gasterosteus aculeatus, L.)

In situ effects of metal contamination from former uranium mining sites on the health of the three-spined stickleback (Gasterosteus aculeatus, L.)

Acclimation capacity of the three-spined stickleback (Gasterosteus aculeatus, L.) to a sudden biological stress following a polymetallic exposure

Multiple Stressor Effects of Radon and Phthalates in Children: Background Information and Future Research

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