Subjective reward value of visual sexual stimuli is coded in human striatum and orbitofrontal cortex

Klein, Susanne; Markert, Charlotte; Strahler, Jana; Stark, Rudolf

doi:10.1016/j.bbr.2020.112792

Cited by 15 publications

(19 citation statements)

References 56 publications

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“…Following a variable time interval, a target was presented for a short time, to which the participants were asked to react as quickly as possible by pressing a button. If the cue in the anticipation phase was a Cue VSS or a Cue Control , a corresponding video could be obtained by reacting quickly to the target (see also Klein et al, 2020) motivation" used in this scale includes sexual activities with a partner as well as solitary sexual activities. Higher values indicate higher trait sexual motivation.…”

Section: Methodsmentioning

confidence: 99%

“…One other study using data from this project has been published so far. Klein et al (2020) examined the influence of individual preference on neural reactivity to VSS. The analyses showed that several reward-associated brain areas correlate positively with the individual rating of the VSS and that this correlation correlates positively with the level of PPU.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Sexual incentive delay in the scanner: Sexual cue and reward processing, and links to problematic porn consumption and sexual motivation

Markert

Klein

Strahler

et al. 2021

JBA

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Background and aimsThe use of pornography, while unproblematic for the majority, can grow into addiction-like behavior which in its extreme form is labeled as compulsive sexual behavioral disorder in the ICD-11 (WHO, 2018). The aim of this study was to investigate the addiction-specific reactivity to cues in order to better understand underlying mechanisms in the development of this disorder.MethodsWe have used an optimized Sexual Incentive Delay Task to study brain activity in reward associated brain areas during an anticipation phase (with cues predicting pornographic videos, control videos or no videos) and a corresponding delivery phase in healthy men. Correlations to indicators of problematic pornography use, the time spent on pornography use, and trait sexual motivation were analyzed.ResultsThe results of 74 men showed that reward-related brain areas (amygdala, dorsal cingulate cortex, orbitofrontal cortex, nucleus accumbens, thalamus, putamen, caudate nucleus, and insula) were significantly more activated by both the pornographic videos and the pornographic cues than by control videos and control cues, respectively. However, we found no relationship between these activations and indicators of problematic pornography use, time spent on pornography use, or with trait sexual motivation.Discussion and conclusionsThe activity in reward-related brain areas to both visual sexual stimuli as well as cues indicates that optimization of the Sexual Incentive Delay Task was successful. Presumably, associations between reward-related brain activity and indicators for problematic or pathological pornography use might only occur in samples with increased levels and not in a rather healthy sample used in the present study.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Sexual incentive delay in the scanner: Sexual cue and reward processing, and links to problematic porn consumption and sexual motivation

Markert

Klein

Strahler

et al. 2021

JBA

Self Cite

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“…And correlative evidence supporting this role continues to accumulate; in various choice tasks, neuronal activity in the OFC correlates with value in fMRI imaging, electrophysiological, and calcium imaging studies [13][14][15][16][17][18][19][20]. These value representations are adaptive to outcome and context changes [15,21,22], modulated by gaze fixation [23] and covert shift of attention [24], and supported by a mixture of temporally dynamic and stable coding schemes [25].…”

Section: Neural Correlates Of Value In the Ofcmentioning

confidence: 98%

Is the core function of orbitofrontal cortex to signal values or make predictions?

Zhou

Gardner

Schoenbaum

2021

Current Opinion in Behavioral Sciences

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One dominant hypothesis about the function of the orbitofrontal cortex (OFC) is that the OFC signals the subjective values of possible outcomes to other brain areas for learning and decision making. This popular view generally neglects the fact that OFC is not necessary for simple value-based behavior (i.e., when values have been directly experienced). An alternative, emerging view suggests that OFC plays a more general role in representing structural information about the task or environment, derived from prior experience, and relevant to predicting behavioral outcomes, such as value. From this perspective, value signaling is simply one derivative of the core underlying function of OFC. New data in favor of both views have been accumulating rapidly. Here we review these new data in discussing the relative merits of these two ideas.

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“…In addition, preference for primary over secondary rewards is also observed in the amygdala and anterior part of the insula (Haber & Knutson, 2010;Sescousse, Cald u, et al, 2013). However, to our knowledge unlike ventral striatal (Brand, Snagowski, Laier, & Maderwald, 2016;Gola, Wordecha, et al, 2017;K€ uhn & Gallinat, 2014;Voon et al, 2014), the activity of the thalamus, OFC, amygdala and, insula have not yet been extensively studied in CSBD, especially in the cue-evoked anticipatory phase of reward processing, whilst the initial evidence suggests that aberrant patterns of explicit sexual stimuli processing in CSBD may involve these structures (Antons & Brand, 2020;Klein et al, 2020;Sinke et al, 2020;Voon et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Aberrant orbitofrontal cortex reactivity to erotic cues in Compulsive Sexual Behavior Disorder

Golec

Draps

Stark

et al. 2021

JBA

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Background and aimsCompulsive Sexual Behavior Disorder (CSBD) is characterized by increased reactivity to erotic reward cues. Cue-encoded reward parameters, such as type (e.g. erotic or monetary) or probability of anticipated reward, shape reward-related motivational processes, increase the attractiveness of cues and therefore might enhance maladaptive behavioral patterns in CSBD. Studies on the neural patterns of cue processing in individuals with CSBD have been limited mainly to ventral striatal responses. Therefore, here we aimed to examine the cue reactivity of multiple key structures in the brain's reward system, taking into account not only the type of predicted reward but also its probability.MethodsTwenty Nine men seeking professional help due to CSBD and 24 healthy volunteers took part in an fMRI study with a modified Incentive Delay Task with erotic and monetary rewards preceded by cues indicating a 25%, 50%, or 75% chance of reward. Analyses of functional patterns of activity related to cue type and probability were conducted on the whole-brain and ROI levels.ResultsIncreased anticipatory response to cues predictive of erotic rewards was observed among CSBD participants when compared to controls, in the ventral striatum and anterior orbitofrontal cortex (aOFC). The activity in aOFC was modulated by reward probability.Discussion and conclusionsType of anticipated reward (erotic vs monetary) affects reward-related behavioral motivation in CSBD more strongly than reward probability. We present evidence of abnormal aOFC function in CSBD by demonstrating the recruitment of additional subsections of this region by erotic reward cues.

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Subjective reward value of visual sexual stimuli is coded in human striatum and orbitofrontal cortex

Cited by 15 publications

References 56 publications

Sexual incentive delay in the scanner: Sexual cue and reward processing, and links to problematic porn consumption and sexual motivation

Sexual incentive delay in the scanner: Sexual cue and reward processing, and links to problematic porn consumption and sexual motivation

Is the core function of orbitofrontal cortex to signal values or make predictions?

Aberrant orbitofrontal cortex reactivity to erotic cues in Compulsive Sexual Behavior Disorder

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