1993
DOI: 10.1152/ajpregu.1993.265.2.r302
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Abstract: In this study, we have utilized electrophysiological single unit recordings to evaluate the effects of nonpeptidergic angiotensin II (ANG II) antagonists on neural responses of hypothalamic paraventricular nucleus (PVN) neurons to either electrical stimulation in subfornical organ (SFO) or direct application of ANG II. Electrical stimulation (200-400 microA; 0.1 ms) in the SFO resulted in excitatory responses in 36 of 50 PVN neurons tested. Peristimulus histogram analysis of such excitatory effects demonstrate… Show more

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Cited by 98 publications
(110 citation statements)
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“…Electrophysiological studies demonstrate that ANG II can increase PVN unit discharge when applied either directly within the SFO or when given systemically (1,15). Together, available evidence indicates that ANG II is a likely neurotransmitter released from SFO terminals within the PVN (22,41). Furthermore, parvocellular neurons of the PVN project to regions of the CNS that control sympathetic outflow (36), including the rostral ventrolateral medulla, the dorsomedial medulla, and the spinal intermediolateral cell column (26,36,39).…”
Section: Discussionmentioning
confidence: 99%
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“…Electrophysiological studies demonstrate that ANG II can increase PVN unit discharge when applied either directly within the SFO or when given systemically (1,15). Together, available evidence indicates that ANG II is a likely neurotransmitter released from SFO terminals within the PVN (22,41). Furthermore, parvocellular neurons of the PVN project to regions of the CNS that control sympathetic outflow (36), including the rostral ventrolateral medulla, the dorsomedial medulla, and the spinal intermediolateral cell column (26,36,39).…”
Section: Discussionmentioning
confidence: 99%
“…Although additional studies are required to specifically define the CNS circuitry involved in our observed attenuated VE-induced renal SNA responses in the presence of chronic increases of ANG II, several studies demonstrate that the paraventricular nucleus of the hypothalamus (PVN) is one particular site in the CNS that is important for receiving and processing ANG II-sensitive inputs from forebrain circumventricular organs (CVOs) (3,14,22,40 In conclusion, the present study demonstrates that elevated circulating ANG II attenuates the renal sympathoinhibitory response to acute VE. Observed responses appear to require chronic ANG II treatment and AT 1 receptor activation.…”
Section: Discussionmentioning
confidence: 99%
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“…One of the main pathways involved in these functions comprises the SFO efferent projections to the supraoptic and the paraventricular nuclei [42][43][44][45][46][47]. It seems likely, therefore, that, during the present imprinting, SFO excitability may trigger SFO-SON pathway sensitization and, when the offspring is challenged by a hypovolemic thirst model, the vasopressinergic cells are more active and in this way modulate fluid drinking secondarily.…”
Section: Discussionmentioning
confidence: 99%