Subepidermal calcified nodules

Shmunes, E.

doi:10.1001/archderm.105.4.593

Cited by 13 publications

(4 citation statements)

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“…Dare and Axelsen 3 favoured eccrine duct milia as the origin, because of the CEA‐positive reaction of the cyst wall. It has been suggested that in a subepidermal calcified nodule, the eccrine sweat gland is the initial site of calcium deposits 9 . To our knowledge, no case of syringoma or syringoid tumour localized to the scrotum has been reported so far.…”

Section: Discussionmentioning

confidence: 92%

Dystrophic scrotal calcinosis originating from benign eccrine epithelial cysts

Ito

Sakamoto

Ito

2001

British Journal of Dermatology

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Scrotal calcinosis has been classified as a form of idiopathic calcinosis cutis. However, the pathogenesis of the calcified nodules has not been fully elucidated: it is still unclear whether the condition is truly idiopathic, or the result of breakdown of calcified epithelial cysts. We describe a 29-year-old Japanese patient with scrotal calcinosis originating from epithelial cysts. Light microscopy revealed a large epithelial cyst containing von Kossa-positive material and several small dilated ductal structures beside the cyst. The epithelia of the cyst and ductal structures were connected, showing similar eccrine duct differentiation on immunohistochemical staining and electron microscopy. In the cyst lumen, calcium was present as needle-shaped crystals. The pathogenetic mechanism of calcium deposition seemed to be due to excessive production and discharge of matrical debris and sulphated mucopolysaccharides, which derived from luminal cells, and their accumulation in the lumina.

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Section: Discussionmentioning

confidence: 92%

Dystrophic scrotal calcinosis originating from benign eccrine epithelial cysts

Ito

Sakamoto

Ito

2001

British Journal of Dermatology

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“…Clinically, SCN is presented as a single raised, well circumscribed, whitish and hard nodule with a smooth or verrucous surface9. Multiple lesions can also be seen, but less often17. The most common location of SCN is the face18.…”

Section: Discussionmentioning

confidence: 99%

A Case of a Subepidermal Calcified Nodule on the Sole without Trauma

et al. 2011

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Subepidermal calcified nodule is an uncommon form of calcinosis cutis, which most commonly occurs in children. It usually presents as an asymptomatic, solitary verrucous nodule on the head and neck region, but occasionally as multiple lesions. Serum calcium and phosphorus levels are usually normal. Histopathology shows well-formed homogeneous eosinophilic material and granules in the upper dermis. Material in the dermis stained with von Kossa was positive. We report on an unusual case of a subepidermal calcified nodule occurring on the sole. A 21-month-old male presented with an oval-shaped, whitish, hard nodule measuring 5×5 mm on the left sole, without any previous history of trauma.

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“…Idiopathic subepidermal calcium deposits have been attributed to the active role of the sweat duct. This is supported by the occurrence of an increased sweat calcium level coincident with a normal scrum calcium level (Shmunes & Wood 1972). Also, there have been reports of congenital calcium deposits of the skin at the site of sweat ducts and pores (Winer 1952).…”

Section: Discussionmentioning

confidence: 99%

“…(Received for publication September 5, 1980) Idiopathic calcinosis cutis may be tumoral (Whiting et al 1970) or multiple (Shmunes & Wood 1972). We want to call attention to small miliary pinhead size perineal lesions as a manifestation of calcinosis cutis.…”

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confidence: 99%