Subdural Empyema due to Salmonella Infection

Jain, Kapila; Mahapatra, Ashok Kumar

doi:10.1159/000028627

Cited by 16 publications

(12 citation statements)

References 4 publications

(11 reference statements)

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“…In addition to typical meningitis, focal intracranial infections with NTS can occur with or without meningitis. Principal among these are subdural empyema and brain abscess (178,213,232,236,328,337,404).…”

Section: Salmonella Speciesmentioning

confidence: 99%

Invasion of the Central Nervous System by Intracellular Bacteria

2004

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Infection of the central nervous system (CNS) is a severe and frequently fatal event during the course of many diseases caused by microbes with predominantly intracellular life cycles. Examples of these include the facultative intracellular bacteria Listeria monocytogenes, Mycobacterium tuberculosis, and Brucella and Salmonella spp. and obligate intracellular microbes of the Rickettsiaceae family and Tropheryma whipplei. Unfortunately, the mechanisms used by intracellular bacterial pathogens to enter the CNS are less well known than those used by bacterial pathogens with an extracellular life cycle. The goal of this review is to elaborate on the means by which intracellular bacterial pathogens establish infection within the CNS. This review encompasses the clinical and pathological findings that pertain to the CNS infection in humans and includes experimental data from animal models that illuminate how these microbes enter the CNS. Recent experimental data showing that L. monocytogenes can invade the CNS by more than one mechanism make it a useful model for discussing the various routes for neuroinvasion used by intracellular bacterial pathogens

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Section: Salmonella Speciesmentioning

confidence: 99%

Invasion of the Central Nervous System by Intracellular Bacteria

2004

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“…The infections are in the form of meningitis, subdural effusions and empyemas [4, 7, 8, 11, 12, 13, 14, 15, 16, 17], extradural empyema [1, 5, 6, 17], brain abscess and cerebral venous infarcts. Rarely, there can be association of more than one pathology [2, 4, 9, 11].…”

Section: Discussionmentioning

confidence: 99%

“…Only about 80 cases of focal intracranial infections have been reported [1], which includes our 6 cases. Among these are 22 brain abscesses, 40 subdural empyemas and another 18 cases with combinations of two or more pathologies, mostly as case reports [1, 2, 4, 7, 8, 9, 11, 13, 14, 15, 16, 17, 18, 19]. No large series of subdural empyema due to Salmonella infection has been reported in the literature, which highlights the rarity and paucity of the literature on this entity.…”

Section: Discussionmentioning

confidence: 99%

“…Surprisingly, large numbers of cases may not have an obvious history of Salmonella infection [4, 11, 14], and the diagnosis is only made following the isolation of the organism in pus culture. In our study, there was no past history of typhoid fever in 4 patients, even though all the patients presented with fever.…”

Section: Discussionmentioning

confidence: 99%

“…The victims of Salmonella intracranial abscess are by and large infants and children [1, 2, 3, 4, 9, 14, 16, 17]. These patients are rarely adults [4, 11, 15, 18].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Intracranial Salmonella Infections: Meningitis, Subdural Collections and Brain Abscess

Mahapatra

Pawar²,

Sharma³

2002

Pediatr Neurosurg

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Focal intracranial infections due to Salmonella are rare. So far, around 80 cases have been reported in the world literature. The authors present their experience of 6 cases of intracranial Salmonella infections, mainly subdural empyema in 5 and effusion in 1. In 1 case, subdural empyema was bilateral, and in another case, there was an associated brain abscess. Positive blood cultures and positive Widal tests were noticed in 2 patients each. Early diagnosis and prompt evacuation of subdural collections and brain abscess and antibiotic therapy lead to satisfactory results. This study suggests that a high index of suspicion, early diagnosis and quick evacuation lead to success; this point is highlighted with the help of a review of the literature.

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