Subcutaneous sclerosis with fasciitis and eosinophilia after phytonadione injections

Janin-Mercier, A.

doi:10.1001/archderm.121.11.1421

Cited by 16 publications

(3 citation statements)

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“…However, since then, patients with no signs of liver disease have been described: therefore, the high prevalence of adverse reactions in patients with hepatic disease probably depends on the large number of hepatopathic patients needing treatment with vitamin K (2). To the best of our knowledge, no cases have been described in which orally administered vitamin K resulted in adverse reactions: only parenteral oil-soluble vitamin K seems to be able to react (1)(2)(3)(4)(5)(6)(7)(8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

Adverse skin reactions to vitamin K₁: report of 2 cases

Balato

Patruno

et al. 1998

Contact Dermatitis

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Vitamin K is essential to the biosynthesis of prothrombin and other clotting factors (VII, IX and X), and is mostly used for the prophylaxis of bleeding disorders, mainly in patients with hepatic disfunction (1). 4 different pharmacological forms exist: the natural form K1 (phytomenadione); K2 (menaquinone), which is derived from intestinal bacterial action; K3 (menadione); and K4 (menadiol). The latter 2 are synthetic products. In Italy, only vitamin K1 is marketed (2). Adverse cutaneous reactions to vitamin K are rare; 2 are mainly reported: an erythematous plaque (3, 4) or pseudo‐scleroderma (5) at the injection site. Contact dermatitis and localized urticarial lesions have also been described (2).

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Section: Discussionmentioning

confidence: 99%

Adverse skin reactions to vitamin K₁: report of 2 cases

Balato

Patruno

et al. 1998

Contact Dermatitis

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“…The second type appears as a scleroderma or morphea-like reaction. [53][54][55][56] The onset can be weeks to months, and the skin change may last for years. 39 Dose does not appear to bear a relationship to the onset of these reactions.…”

Section: Adverse Effects Of Vitamin Kmentioning

confidence: 99%

Phytonadione Therapy in a Multiple‐Drug Overdose Involving Warfarin

Bates

Mintz

2000

Pharmacotherapy

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We cared for a patient who ingested an unknown amount of acetaminophen with zopiclone and warfarin. The only liver function test that was abnormal was an increased international normalized ratio (INR), which remained elevated despite treatment with subcutaneous phytonadione and a prolonged infusion of N-acetylcysteine. An interaction between acetaminophen and warfarin may have decreased the hepatic metabolism of warfarin. The patient received numerous antibiotics that may have contributed to the increased INR. The prolonged elevation of INR also may have been due to infrequent administration of phytonadione.

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“…1 Sclerodermoid reactions, sometimes referred to as pseudoscleroderma, are acquired cutaneous reactions that clinically and histologically resemble localized scleroderma (morphea). Drugs that have been implicated in sclerodermoid reactions include vitamin B12, 2,3 vitamin K (Texier's disease), [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] and pentazocine. 20,21 Vitamin B12 sclerodermoid reactions have been noted in Europe, but to our knowledge have not been reported elsewhere.…”

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Vitamin B12-Associated Localized Scleroderma and Its Treatment

ROTHCHILD²,

Sengelmann³

2004

Dermatologic Surgery

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BACKGROUND. Localized drug-induced injection site reactions are rare. Injection site sclerodermoid reactions have been reported as a result of multiple drugs, most commonly vitamin K. Sclerodermoid injection site reactions have also been reported with pentazocine, progestin, and vitamin B12. Little has been written on the efficacious treatment of this complication. OBJECTIVE. The objective was to raise awareness of the potential complication of localized sclerodermoid change secondary to vitamin B12 injections and to present a novel approach to its treatment. METHODS. We report a case and review the English literature for injection site reactions from vitamin B12 as well as treatment options for this complication.

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Subcutaneous sclerosis with fasciitis and eosinophilia after phytonadione injections

Cited by 16 publications

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Adverse skin reactions to vitamin K₁: report of 2 cases

Adverse skin reactions to vitamin K₁: report of 2 cases

Phytonadione Therapy in a Multiple‐Drug Overdose Involving Warfarin

Vitamin B12-Associated Localized Scleroderma and Its Treatment

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Subcutaneous sclerosis with fasciitis and eosinophilia after phytonadione injections

Cited by 16 publications

References 0 publications

Adverse skin reactions to vitamin K1: report of 2 cases

Adverse skin reactions to vitamin K1: report of 2 cases

Phytonadione Therapy in a Multiple‐Drug Overdose Involving Warfarin

Vitamin B12-Associated Localized Scleroderma and Its Treatment

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Adverse skin reactions to vitamin K₁: report of 2 cases

Adverse skin reactions to vitamin K₁: report of 2 cases