Subcutaneous Immunoglobulin Therapy in a Woman with Spontaneous Pregnancy Loss and Multiple Sclerosis

Carbone, Javier; Sarmiento, E.; Cruz, Elena de la

doi:10.21767/2476-1974.100010

Reproductive Immunol Open Acc

2016

DOI: 10.21767/2476-1974.100010

|View full text |Cite

Subcutaneous Immunoglobulin Therapy in a Woman with Spontaneous Pregnancy Loss and Multiple Sclerosis

Javier Carbone¹,

E. Sarmiento²,

Elena de la Cruz³

Abstract: Background: Off-label use of intravenous immunoglobulin has been reported for the treatment of recurrent spontaneous pregnancy loss and selected cases of multiple sclerosis.However, the use of subcutaneous immunoglobulin has not been reported in these settings.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2016

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a case report, Carbone et al [3] have demonstrated an innovative approach to immunomodulation in women with recurrent pregnancy loss and immunological abnormalities. Although the safety and efficacy of this approach needs further evaluation in large clinical trials, the authors have successfully demonstrated the tolerability and clinical efficacy of subcutaneous immunoglobulin therapy for unexplained abortion and multiple sclerosis.…”

mentioning

confidence: 99%

Cellular and Molecular Mechanisms in Reproductive Immunology

Nayak¹

2016

Reproductive Immunol Open Acc

View full text Add to dashboard Cite

Reproductive immunology is a field of medicine which studies the interactions between reproductive tissues and the immune system. It offers solutions to various reproductive disorders associated with immune dysfunctions, such as infertility problems of men and women, recurrent miscarriages, cancers of reproductive tissues, fibroids, and various pregnancy complications. Reproductive Immunology: Open Access (RIOA) is an international, peer-reviewed, journal that publishes new articles in all the related topics of reproductive immunology. The main goal of the journal is to provide a forum for researchers and clinicians to disseminate new research findings and concepts related to the field of reproductive immunobiology. Here, we highlight several novel findings recently published in RIOA.Using a genome-wide association study (GWAS), Sugimoto et al. [1] provide novel insights into the role of friend leukaemia integration 1 (FLI-1), a member of the ETS gene family of transcription factors, in regulation of conception rates in Holstein cows. They have shown that cows with higher conception rates have the GA polymorphism in the FLI-1 5' untranslated region and express higher levels of FLI-1 transcripts with the GA polymorphism. Furthermore, they have shown that cows with the deletion polymorphism had lower conception rate after embryo transfer and had higher serum levels of perforin, a product of natural killer cells, which might have contributed to the lower conception rate in these animals.McCracken and colleagues [2] have discovered a potential mechanism of suppression of the maternal Th1 immunity during normal pregnancy. They have shown that pregnancy derived Fas ligand (FasL) exosomes in maternal plasma regulate p65 levels in circulating T-cells through Fas activation, and that the suppression of p65 subunit of the nuclear factor kappa-lightchain-enhancer of activated B cells (NF-kB) in T-cells underlies the suppression of maternal Th1 immunity during pregnancy.In a case report, Carbone et al. [3] have demonstrated an innovative approach to immunomodulation in women with recurrent pregnancy loss and immunological abnormalities. Although the safety and efficacy of this approach needs further evaluation in large clinical trials, the authors have successfully demonstrated the tolerability and clinical efficacy of subcutaneous immunoglobulin therapy for unexplained abortion and multiple sclerosis.

show abstract

mentioning

confidence: 99%

Cellular and Molecular Mechanisms in Reproductive Immunology

Nayak¹

2016

Reproductive Immunol Open Acc

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Subcutaneous Immunoglobulin Therapy in a Woman with Spontaneous Pregnancy Loss and Multiple Sclerosis

Abstract: Background: Off-label use of intravenous immunoglobulin has been reported for the treatment of recurrent spontaneous pregnancy loss and selected cases of multiple sclerosis.However, the use of subcutaneous immunoglobulin has not been reported in these settings.

Cited by 1 publication

References 12 publications

Cellular and Molecular Mechanisms in Reproductive Immunology

Cellular and Molecular Mechanisms in Reproductive Immunology

Contact Info

Product

Resources

About