Subcutaneous Fat in Leukemia and Lymphoma

Trubowitz, Sidney; Sims, Charles F.

doi:10.1001/archderm.1962.01590100134025

Cited by 78 publications

(6 citation statements)

References 4 publications

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“…In this old study dating back to 1962, WAT samples of 60 patients who died of leukemia or lymphoma were analyzed. 19 of them showed subcutaneous WAT infiltrations of malignant cells in apparently normal skin [65]. This is a remarkable observation, given the fact that WAT was commonly regarded as negligible organ in leukemia.…”

Section: Open Questions and Future Directions Of Scientific Researchmentioning

confidence: 86%

“…Back in 1962, infiltrations of leukemia or lymphoma cells were identified in subcutaneous AT of patients [65]. In mice, HSCs are not only found in the BM, but also in extramedullary gonadal WAT (gWAT) [66].…”

Section: Influence Of Other Fat Depots On Normal and Malignant Hematomentioning

confidence: 99%

“…Another important finding that requires appropriate follow-up is the accumulation of leukemia cells in WAT found in several mouse models [67,68,71] but also in humans [65]. In this old study dating back to 1962, WAT samples of 60 patients who died of leukemia or lymphoma were analyzed.…”

Section: Open Questions and Future Directions Of Scientific Researchmentioning

confidence: 99%

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Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

Zinngrebe¹,

Debatin²,

Fischer‐Posovszky³

2020

Leukemia

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The bone marrow is home to well-balanced normal hematopoiesis, but also the stage of leukemia’s crime. Marrow adipose tissue (MAT) is a unique and versatile component of the bone marrow niche. While the importance of MAT for bone health has long been recognized, its complex role in hematopoiesis has only recently gained attention. In this review article we summarize recent conceptual advances in the field of MAT research and how these developments impact our understanding of MAT regulation of hematopoiesis. Elucidating routes of interaction and regulation between MAT and cells of the hematopoietic system are essential to pinpoint vulnerable processes resulting in malignant transformation. The concept of white adipose tissue contributing to cancer development and progression on the cellular, metabolic, and systemic level is generally accepted. The role of MAT in malignant hematopoiesis, however, is controversial. MAT is very sensitive to changes in the patient’s metabolic status hampering a clear definition of its role in different clinical situations. Here, we discuss future directions for leukemia research in the context of metabolism-induced modifications of MAT and other adipose tissues and how this might impact on leukemia cell survival, proliferation, and antileukemic therapy.

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Section: Open Questions and Future Directions Of Scientific Researchmentioning

confidence: 86%

Section: Influence Of Other Fat Depots On Normal and Malignant Hematomentioning

confidence: 99%

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Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

Zinngrebe¹,

Debatin²,

Fischer‐Posovszky³

2020

Leukemia

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“… 67 In an earlier study, leukemia cells and lymphoma cells were found in pericardial fat and subcutaneous WAT. 68 Compared with 3/12 mice in the control group, there are 7/12 DIO mice treated with vincristine after injecting highly malignant pre‐b lymphoblastic BCR/ABL+ leukemia cells developed progressive leukemia. These findings highlight that adipocytes may be responsible for the relapse of ALL resistance in obese leukemia patients.…”

Section: Other Adipose Tissue Affects Hematopoietic Homeostasismentioning

confidence: 99%

Adipose tissue and hematopoiesis: Friend or foe?

Liu

2023

Clinical Laboratory Analysis

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Aim Hematopoietic stem cells are the origin of all hematopoietic cells. They have the self‐renewal ability and can differentiate into various blood cells. In physiological state, most of the hematopoietic stem cells are dormant, and only a few cells proliferate to maintain hematopoietic homeostasis. Methods This precise steady‐state maintenance is regulated by complex mechanisms. Bone marrow adipocytes make up half of all cells in the bone marrow cavity, a feature that has attracted the attention of researchers from multiple fields. The adipocyte density within marrow increases during aging and obesity. Results Recent studies have shown that bone marrow adipocytes play important roles in regulating hematopoiesis, but the effects of bone marrow adipocytes on hematopoiesis are often conflicting. Bone marrow adipocytes, participating in the formation of bone marrow hematopoietic microenvironment, influence hematopoiesis positively or negatively. In addition, other adipose tissue, especially white adipose tissue, also regulates hematopoiesis. Conclusion In this review, we describe the role of adipose tissue in hematological malignancies, which may be useful for understanding hematopoiesis and the pathogenesis of related diseases.

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“…This was based on their post-mortem biopsies of apparently uninvolved abdominal skin of patients with either leukemia or lymphoma that found infiltration of subcutaneous tissue in 30%. 61 It is interesting that three decades earlier, cancer pathologist James Ewing had observed "plasma cell changes occur mainly in fat areas". 62 Among the cells that compose adipose tissue are adipocytes, preadipocytes, fibroblasts, macrophages, stromal cells, endothelial cells and monocytes.…”

Section: Adipose Tissue In Extramedullary Sitesmentioning

confidence: 99%

Single organ microenvironment and the common features of tumors of leukemia, lymphoma, and myeloma cells growing there: A literature review

Cunningham

Sosa²,

Hamele‐Bena

2021

European J of Haematology

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The tumor manifestations of leukemia, lymphoma, and multiple myeloma in body organs have been described for over a century.While the natural histories of each type of solid tumor is well known, that of hematologic tumors in the same organ site have not been elucidated. Knowledge of hematologic tumors has been limited to their description in individual case reports of tumors in any organ.The natural history of hematologic tumors in individual sites and their metastatic patterns has not been tracked, except for tumors at a few sites. Similar patterns of growth and spread between leukemic and solid tumors in breast, ovary, and GI sites were revealed. [1][2][3] Extensive studies of leukemic breast tumors and specimen analyses found histologic and genetic similarities of leukemic to solid breast cancers. 4 The present literature review was undertaken to ascertain

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Subcutaneous Fat in Leukemia and Lymphoma

Cited by 78 publications

References 4 publications

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

Adipose tissue and hematopoiesis: Friend or foe?

Single organ microenvironment and the common features of tumors of leukemia, lymphoma, and myeloma cells growing there: A literature review

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