Subcortical Volume Loss in the Thalamus, Putamen, and Pallidum, Induced by Traumatic Brain Injury, Is Associated With Motor Performance Deficits

Gooijers, Jolien; Chalavi, Sima; Beeckmans, Kurt; Michiels, Karla; Lafosse, Christophe; Sunaert, Stefan; Swinnen, Stephan P.

doi:10.1177/1545968315613448

Cited by 43 publications

(41 citation statements)

References 50 publications

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“…Similar to the findings in this study, thalamic lesions and volume abnormalities appear to be a consistent finding across TBI studies [20] regardless of the methods used to quantify the differences in thalamic size (i.e., manual, automated, and voxel based methods). In one of the only studies to use shape analyses, global atrophic surface changes were seen in bilateral thalami in a sample of 21 moderate to severe TBI patients [40].…”

Section: Discussionsupporting

confidence: 87%

Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury

et al. 2016

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Mild traumatic brain injury (mTBI) is a significant health concern. The majority who sustain mTBI recover, although ~20 % continue to experience symptoms that can interfere with quality of life. Accordingly, there is a critical need to improve diagnosis, prognostic accuracy, and monitoring (recovery trajectory over time) of mTBI. Volumetric magnetic resonance imaging (MRI) has been successfully utilized to examine TBI. One promising improvement over standard volumetric approaches is to analyze high-dimensional shape characteristics of brain structures. In this study, subcortical shape and volume in 76 Service Members with mTBI was compared to 59 Service Members with orthopedic injury (OI) and 17 with post-traumatic stress disorder (PTSD) only. FreeSurfer was used to quantify structures from T1-weighted 3 T MRI data. Radial distance (RD) and Jacobian determinant (JD) were defined vertex-wise on parametric mesh-representations of subcortical structures. Linear regression was used to model associations between morphometry (volume and shape), TBI status, and time since injury (TSI) correcting for age, sex, intracranial volume, and level of education. Volumetric data was not significantly different between the groups. JD was significantly increased in the accumbens and caudate and significantly reduced in the thalamus of mTBI participants. Additional significant associations were noted between RD of the amygdala and TSI. Positive trendlevel associations between TSI and the amygdala and accumbens were observed, while a negative association was observed for third ventricle. Our findings may aid in the initial diagnosis of mTBI, provide biological targets for functional examination, and elucidate regions that may continue remodeling after injury.

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Section: Discussionsupporting

confidence: 87%

Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury

et al. 2016

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“…Meanwhile, we also found that volume alterations in the left-putamen and right-thalamus were negatively correlated with the auditory recognition reaction time and F I G U R E 3 Tract-based spatial statistics maps are shown the FA differences in experimental and control groups. Volume of thalamus has been found to be associated with recognition in previous study (Gooijers et al, 2016), and our current study provides further evidence for this association. HA, high altitude; FA, fractional anisotropy [Color figure can be viewed at wileyonlinelibrary.com] auditory simple reaction time changes.…”

Section: Discussionsupporting

confidence: 85%

“…Meanwhile, we also found that volume alterations in the left-putamen and right-thalamus were negatively correlated with the auditory recognition reaction time and with working memory and cognitive flexibility, was observed structural connectivity with attention and memory related brain regions (Starr et al, 2011). Volume of thalamus has been found to be associated with recognition in previous study (Gooijers et al, 2016), and our current study provides further evidence for this association. All these findings suggested the potential relationship between the brain anatomical changes and working memory or reaction time, and highlighted the importance of evaluating the cognitive impairment of chronic HA exposure.…”

Section: Discussionsupporting

confidence: 78%

Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study

Chen

Zhang

et al. 2019

Human Brain Mapping

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The study of individuals at high‐altitude (HA) exposure provides an important opportunity for unraveling physiological and psychological mechanism of brain underlying hypoxia condition. However, this has rarely been assessed longitudinally. We aim to explore the cognitive and cerebral microstructural alterations after chronic HA exposure. We recruited 49 college freshmen who immigrated to Tibet and followed up for 2 years. Control group consisted of 49 gender and age‐matched subjects from sea level. Neuropsychological tests were also conducted to determine whether the subjects' cognitive function had changed in response to chronic HA exposure. Surface‐based cortical and subcortical volumes were calculated from structural magnetic resonance imaging data, and tract‐based spatial statistics (TBSS) analysis of white matter (WM) fractional anisotropy (FA) based on diffusion weighted images were performed. Compared to healthy controls, the high‐altitude exposed individuals showed significantly lower accuracy and longer reaction times in memory tests. Significantly decreased gray matter volume in the caudate region and significant FA changes in multiple WM tracts were observed for HA immigrants. Furthermore, differences in subcortical volume and WM integration were found to be significantly correlated with the cognitive changes after 2 years' HA exposure. Cognitive functions such as working memory and psychomotor function were found to be impaired during chronic HA. Differences of brain subcortical volumes and WM integration between HA and sea‐level participants indicated potential impairments in the brain structural modifications and microstructural integrity of WM tracts after HA exposure.

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“…Putamen contributes to the regulation of voluntary movement and learning, while FIM evaluates the capability to execute movements and finalized motor procedures. A previous study found that atrophy of the thalamus, putamen, and pallidus following TBI is associated with motor dysfunction. Another one found no relation between putamen atrophy and walking parameters in paediatric TBI.…”

Section: Discussionmentioning

confidence: 93%

Fronto‐temporal vulnerability to disconnection in paediatric moderate and severe traumatic brain injury

Molteni

Pagani

Strazzer

et al. 2019

Euro J of Neurology

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Background In patients with moderate and severe paediatric traumatic brain injury (TBI), we investigated the presence and severity of white matter (WM) tract damage, cortical lobar and deep grey matter (GM) atrophies, their interplay and their correlation with outcome rating scales. Methods Diffusion tensor (DT) and 3D T1‐weighted MRI scans were obtained from 22 TBI children (13 boys; mean age at insult = 11.6 years; 72.7% in chronic condition) and 31 age‐matched healthy children. Patients were tested with outcome rating scales and the Wechsler Intelligence Scale for Children (WISC). DT MRI indices were obtained from several supra‐ and infra‐tentorial WM tracts. Cortical lobar and deep GM volumes were derived. Comparisons between patients and controls, and between patients in acute (<6 months from the event) vs. chronic (≥6 months) condition were performed. Results Patients showed a widespread pattern of decreased WM FA and GM atrophy. Compared to acute, chronic patients showed severer atrophy in the right frontal lobe and reduced FA in the left inferior longitudinal fasciculus and corpus callosum (CC). Decreased axial diffusivity was observed in acute patients versus controls in the inferior fronto‐occipital fasciculus and CC. Chronic patients showed increased axial diffusivity in the same structures. Uncinate fasciculus DT MRI abnormalities correlated with atrophy in the frontal and temporal lobes. Hippocampal atrophy correlated with reduced WISC scores, whereas putamen atrophy correlated with lower functional independence measure scores. Conclusions The study isolated a distributed fronto‐temporal network of structures particularly vulnerable to axonal damage and atrophy that may contribute to cognitive deficits following TBI.

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Subcortical Volume Loss in the Thalamus, Putamen, and Pallidum, Induced by Traumatic Brain Injury, Is Associated With Motor Performance Deficits

Abstract: Our results reveal that GM atrophy is associated with motor impairments in TBI, providing new insights into the etiology of motor control impairments following brain trauma.

Cited by 43 publications

References 50 publications

Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury

Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury

Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study

Fronto‐temporal vulnerability to disconnection in paediatric moderate and severe traumatic brain injury

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