Subconjunctival Nodules After Amphotericin B Injection

Conjunctiva Necrosis Following Subconjunctival Amphotericin B Injection in Fungal Keratitis

“…In 1973, Randall et al reported a case of fungal ulcer developing subconjunctival nodule following subconjunctival AMB injection. Microscopic examination revealed a fibrosing histiocytic nodule [17]. Retrospective study done by Nada and Bor’i between 2010 to 2015 reported different treatment modalities of fungal keratitis by antifungal agents which included a combination of topical natamycin and subconjunctival amphotericin B in one of the treatment groups.…”

Conjunctiva Necrosis Following Subconjunctival Amphotericin B Injection in Fungal Keratitis

“…In 1973, Randall et al reported a case of fungal ulcer developing subconjunctival nodule following subconjunctival AMB injection. Microscopic examination revealed a fibrosing histiocytic nodule [17]. Retrospective study done by Nada and Bor’i between 2010 to 2015 reported different treatment modalities of fungal keratitis by antifungal agents which included a combination of topical natamycin and subconjunctival amphotericin B in one of the treatment groups.…”

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

“…Local instillation of amphotericin B has been reported using intraviireal (Bell & Ritchey 1973;Perraut et al 1981;Stern et al 1977), intraventricular (Polsky et al 1986;Salaki et al 1984), intrathecal (Diamond & Bennett 1973;Labadie & Hamilton 1986;Salaki et al 1984), intraperitoneal (Eisenberg et al 1986;Struijk et al 1987) and intranasal (Meunier-Carpentier et al 1984) administration as well as by bladder irrigation (Wise et al 1973(Wise et al , 1982 and instillation into the pleural cavity (Hargis et al 1980) and synovial fluid (Khan et al 1983).…”

“…Peritoneal fibrosis may result from intraperitoneal administration (Eisenberg et al 1986) and can cause acute peritoneal irritation, while intravitreal therapy may cause a yellow discoloration of the conjunctiva and the development of nodules (Bell & Ritchey 1973). Bladder irrigation with amphotericin B is generally well tolerated and rarely results in adverse reactions (Gross et al 1987).…”

Conjunctiva Necrosis Following Subconjunctival Amphotericin B Injection in Fungal Keratitis

“…In 1973, Randall et al reported a case of fungal ulcer developing subconjunctival nodule following subconjunctival AMB injection. Microscopic examination revealed a fibrosing histiocytic nodule [17]. Retrospective study done by Nada and Bor’i between 2010 to 2015 reported different treatment modalities of fungal keratitis by antifungal agents which included a combination of topical natamycin and subconjunctival amphotericin B in one of the treatment groups.…”

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

“…Local instillation of amphotericin B has been reported using intraviireal (Bell & Ritchey 1973;Perraut et al 1981;Stern et al 1977), intraventricular (Polsky et al 1986;Salaki et al 1984), intrathecal (Diamond & Bennett 1973;Labadie & Hamilton 1986;Salaki et al 1984), intraperitoneal (Eisenberg et al 1986;Struijk et al 1987) and intranasal (Meunier-Carpentier et al 1984) administration as well as by bladder irrigation (Wise et al 1973(Wise et al , 1982 and instillation into the pleural cavity (Hargis et al 1980) and synovial fluid (Khan et al 1983).…”

“…Peritoneal fibrosis may result from intraperitoneal administration (Eisenberg et al 1986) and can cause acute peritoneal irritation, while intravitreal therapy may cause a yellow discoloration of the conjunctiva and the development of nodules (Bell & Ritchey 1973). Bladder irrigation with amphotericin B is generally well tolerated and rarely results in adverse reactions (Gross et al 1987).…”

Conjunctiva Necrosis Following Subconjunctival Amphotericin B Injection in Fungal Keratitis

“…In 1973, Randall et al reported a case of fungal ulcer developing subconjunctival nodule following subconjunctival AMB injection. Microscopic examination revealed a fibrosing histiocytic nodule [17]. Retrospective study done by Nada and Bor’i between 2010 to 2015 reported different treatment modalities of fungal keratitis by antifungal agents which included a combination of topical natamycin and subconjunctival amphotericin B in one of the treatment groups.…”

Adverse Drug Reactions to Systemic Antifungals Prevention and Management

“…Local instillation of amphotericin B has been reported using intraviireal (Bell & Ritchey 1973;Perraut et al 1981;Stern et al 1977), intraventricular (Polsky et al 1986;Salaki et al 1984), intrathecal (Diamond & Bennett 1973;Labadie & Hamilton 1986;Salaki et al 1984), intraperitoneal (Eisenberg et al 1986;Struijk et al 1987) and intranasal (Meunier-Carpentier et al 1984) administration as well as by bladder irrigation (Wise et al 1973(Wise et al , 1982 and instillation into the pleural cavity (Hargis et al 1980) and synovial fluid (Khan et al 1983).…”

“…Peritoneal fibrosis may result from intraperitoneal administration (Eisenberg et al 1986) and can cause acute peritoneal irritation, while intravitreal therapy may cause a yellow discoloration of the conjunctiva and the development of nodules (Bell & Ritchey 1973). Bladder irrigation with amphotericin B is generally well tolerated and rarely results in adverse reactions (Gross et al 1987).…”