Subconjunctival Injection of the Repository Penicillins

Pharmacokinetics of Sparfloxacin in the Serum and Vitreous Humor of Rabbits: Physicochemical Properties That Regulate Penetration of Quinolone Antimicrobials

“…Carrier-independent penetration of antibiotics and other drugs into the eye (10,13,19,44,53,61), like that at other anatomical sites (3,13,19,30,44,46,53,61), correlates with physicochemical properties, including lipophilicity and MW as well as protein binding. These independent variables were considered in the multiple-linear-regression model.…”

“…Since protein binding clearly affects antibiotic penetration into tissue (30,44,46), studies with quinolones which show greater differences in these properties are planned. It has been difficult to establish rigorous models characterizing the importance of these properties in antibiotic penetration with single samples (56) which are pooled from different animals (10,13,19,44,53,61).…”

Pharmacokinetics of Sparfloxacin in the Serum and Vitreous Humor of Rabbits: Physicochemical Properties That Regulate Penetration of Quinolone Antimicrobials

“…Carrier-independent penetration of antibiotics and other drugs into the eye (10,13,19,44,53,61), like that at other anatomical sites (3,13,19,30,44,46,53,61), correlates with physicochemical properties, including lipophilicity and MW as well as protein binding. These independent variables were considered in the multiple-linear-regression model.…”

“…Since protein binding clearly affects antibiotic penetration into tissue (30,44,46), studies with quinolones which show greater differences in these properties are planned. It has been difficult to establish rigorous models characterizing the importance of these properties in antibiotic penetration with single samples (56) which are pooled from different animals (10,13,19,44,53,61).…”

Pharmacokinetics of Sparfloxacin in the Serum and Vitreous Humor of Rabbits: Physicochemical Properties That Regulate Penetration of Quinolone Antimicrobials

“…Carrier-independent penetration of antibiotics and other drugs into the eye (10,13,19,44,53,61), like that at other anatomical sites (3,13,19,30,44,46,53,61), correlates with physicochemical properties, including lipophilicity and MW as well as protein binding. These independent variables were considered in the multiple-linear-regression model.…”

“…Since protein binding clearly affects antibiotic penetration into tissue (30,44,46), studies with quinolones which show greater differences in these properties are planned. It has been difficult to establish rigorous models characterizing the importance of these properties in antibiotic penetration with single samples (56) which are pooled from different animals (10,13,19,44,53,61).…”

Pharmacokinetics of Sparfloxacin in the Serum and Vitreous Humor of Rabbits: Physicochemical Properties That Regulate Penetration of Quinolone Antimicrobials

“…Carrier-independent penetration of antibiotics and other drugs into the eye (10,13,19,44,53,61), like that at other anatomical sites (3,13,19,30,44,46,53,61), correlates with physicochemical properties, including lipophilicity and MW as well as protein binding. These independent variables were considered in the multiple-linear-regression model.…”

“…Since protein binding clearly affects antibiotic penetration into tissue (30,44,46), studies with quinolones which show greater differences in these properties are planned. It has been difficult to establish rigorous models characterizing the importance of these properties in antibiotic penetration with single samples (56) which are pooled from different animals (10,13,19,44,53,61).…”