Subconjunctival hibernoma in a dog

Stuckey, Jane Ashley; Rankin, Amy J.; Romkes, Gwendolyna; Slack, Jessica L.; Kiupel, Matti; Dubielzig, Richard R.

doi:10.1111/vop.12124

Cited by 7 publications

(11 citation statements)

References 18 publications

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“…An additional reason for weaker immunoreactivity in this study compared to previous reports of canine hibernoma is that the UCP1 antibody was diluted to 1:100 in this study but was 5 times more concentrated in the other reports of canine hibernoma. 25,27 It is unknown in the present study if UCP1 expression by neoplastic cells represents transdifferentiation of white adipocytes to brown adipocytes, aberrant expression of UCP1 in white adipocytes, neoplastic transformation of beige adipocytes, or cross-reaction of the antibody against human UCP1 with a different canine protein.…”

Section: Discussionmentioning

confidence: 89%

Immunoreactivity of Canine Liposarcoma to Muscle and Brown Adipose Antigens

LaDouceur

Stevens

Wood³

et al. 2017

Vet Pathol

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Liposarcoma, rhabdomyosarcoma, and hibernoma share some overlapping histologic and immunohistochemical features. Although immunohistochemistry (IHC) is commonly used in the diagnosis of these neoplasms, expression of muscle markers has been reported in human liposarcoma and canine hibernoma in addition to rhabdomyosarcoma. Thus, these neoplasms are a diagnostic challenge but important to distinguish because of differences in prognosis and treatment. Rhabdomyosarcoma and liposarcoma are both malignant, but rhabdomyosarcoma has a higher potential for metastasis. In contrast, hibernomas are benign with low risk of recurrence. This study investigated expression of the muscle markers desmin, myogenin, and α-smooth muscle actin (α-SMA) and the brown fat marker uncoupling protein 1 (UCP1) in 25 cases of canine liposarcoma using IHC. Oil red O histochemistry was performed to confirm the presence of lipid and the diagnosis of liposarcoma in cases that were not well-differentiated. The 25 cases included 15 well-differentiated, 5 pleomorphic, 3 myxoid, and 2 dedifferentiated subtypes of liposarcoma. By IHC, 23 of 25 expressed UCP1, 7 of 25 expressed α-SMA, 7 of 25 expressed desmin, and 3 of 25 expressed myogenin with no clear relationship of antigen expression and tumor subtype. These findings clarify the immunohistochemical profile of canine liposarcoma and suggest overlap in the expression of several muscle antigens and UCP1 between liposarcoma, hibernoma, and rhabdomyosarcoma.

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Section: Discussionmentioning

confidence: 89%

Immunoreactivity of Canine Liposarcoma to Muscle and Brown Adipose Antigens

LaDouceur

Stevens

Wood³

et al. 2017

Vet Pathol

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“…Diagnosed both in humans and animals, they are localised in various parts of the body and are most frequently described as a lesion developing in mature individuals (Moretti et al 2010, Mavrogenis et al 2011, Stuckey et al 2013. Taking into account the appearance of the cells, character of stroma and presence in the sublayer of the spindle shaped cells, four…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical diagnostic of hibernoma in dog

Dzimira¹,

Kapuśniak²,

Madej³

2015

Polish Journal of Veterinary Sciences

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“…There are several published case reports and small studies of hibernomas in veterinary species, mostly in the orbital region of dogs 1,4‐6 . A subconjunctival hibernoma has been reported in a 2‐year‐old goose 7 .…”

Section: Discussionmentioning

confidence: 99%

Cytologic appearance of hibernoma in two dogs

Piccione

Dial

2020

Veterinary Clinical Pathol

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Hibernomas are rare benign tumors of brown fat (adipose tissue) that have been reported in several different species. The cytologic characterization of these tumors has not been described in dogs. In this case report, we describe two dogs with hibernomas, focusing on the cytologic appearance of these unique neoplasms. Both cytologic specimens were highly cellular and predominated by vacuolated neoplastic cells with no evidence of concurrent inflammation. The cells contained a moderate to large number of variably sized cytoplasmic vacuoles, with occasional, irregularly shaped pink granular material. Most cells contained a single nucleus; however, cells displayed moderate anisokaryosis. A biopsy with histologic examination was performed in both cases, confirming the cytologic suspicion of hibernoma. Immunohistochemistry revealed that both tumors were positive for UCP1 and vimentin, and negative for cytokeratin. Hibernoma is an important differential diagnosis in dogs with conjunctival and periocular swellings that exfoliate numerous, mildly atypical, vacuolated cells.

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Subconjunctival hibernoma in a dog

Cited by 7 publications

References 18 publications

Immunoreactivity of Canine Liposarcoma to Muscle and Brown Adipose Antigens

Immunoreactivity of Canine Liposarcoma to Muscle and Brown Adipose Antigens

Immunohistochemical diagnostic of hibernoma in dog

Cytologic appearance of hibernoma in two dogs

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