2012
DOI: 10.1001/archinternmed.2012.402
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Abstract: Background Data from prospective cohort studies regarding the association between subclinical hyperthyroidism and cardiovascular outcomes are conflicting. We aimed to assess the risks of total and coronary heart disease (CHD) mortality, CHD events, and atrial fibrillation (AF) associated with endogenous subclinical hyperthyroidism among all available large prospective cohorts. Methods Individual data on 52 674 participants were pooled from 10 cohorts. Coronary heart disease events were analyzed in 22 437 par… Show more

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Cited by 451 publications
(407 citation statements)
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References 47 publications
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“…It is feasible that a higher level of TSH can be ameliorated by exogenous thyroid hormones. However, it has not been elucidated whether patients with subclinical hypothyroidism should be treated with thyroid hormones because administration of exogenous thyroid hormones can easily produce iatrogenic subclinical hyperthyroidism with AF 17. Also, previous studies have provided no clear evidence that additional thyroid hormone therapy in subjects with milder forms of subclinical hypothyroidism could improve lipid status and other cardiovascular risk factors,18 as well as symptoms associated with hypothyroidism 19.…”
Section: Discussionmentioning
confidence: 99%
“…It is feasible that a higher level of TSH can be ameliorated by exogenous thyroid hormones. However, it has not been elucidated whether patients with subclinical hypothyroidism should be treated with thyroid hormones because administration of exogenous thyroid hormones can easily produce iatrogenic subclinical hyperthyroidism with AF 17. Also, previous studies have provided no clear evidence that additional thyroid hormone therapy in subjects with milder forms of subclinical hypothyroidism could improve lipid status and other cardiovascular risk factors,18 as well as symptoms associated with hypothyroidism 19.…”
Section: Discussionmentioning
confidence: 99%
“…However, the updated meta-analyses of population cohort studies demonstrated a clear association of hyperthyroidism (even subclinical) with increased cardiovascular morbidity and mortality (14,15). From combined community-based studies, Yang et al (14) concluded that the general population with subclinical hyperthyroidism was at a 31% increased risk of cardiovascular disease.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, melanocortin can exert electrophysiological effects and stimulate the expression of interleukins 16. A recent review demonstrated that subclinical hyperthyroidism is associated with increased coronary heart disease events, mortality, and the incidence of AF 17, 18. Therefore, thyroid hormone may be another potential target that is affected by hsa_circ_025016.…”
Section: Discussionmentioning
confidence: 99%