Subchronic treatment of rats with aurothioglucose; effects on plasma, hepatic, renal and urinary zinc, copper and metallothionein

Localization of the Induced Metallothionein and DNA Damage in Rat Kidney After Gold Injection

“…Although the biological functions of this protein are not fully understood, it is believed to play an important role in the homeostasis of essential metals such as Zn or Cu and in the detoxification of heavy metals such as Cd (Kägi 1993). It has been reported that the content of not only Au but also Cu in renal MT increases after Au treatment in rats (McVety and Shaikh 1987; Saito 1996). Recently we demonstrated that Cu content in the kidney of the Au-injected rat dramatically increased in comparison with Au and Zn content and that Cu-binding MT was predominantly observed in the outer stripe of the outer medulla in the kidney (Saito et al 1997).…”

Localization of the Induced Metallothionein and DNA Damage in Rat Kidney After Gold Injection

“…Although the biological functions of this protein are not fully understood, it is believed to play an important role in the homeostasis of essential metals such as Zn or Cu and in the detoxification of heavy metals such as Cd (Kägi 1993). It has been reported that the content of not only Au but also Cu in renal MT increases after Au treatment in rats (McVety and Shaikh 1987; Saito 1996). Recently we demonstrated that Cu content in the kidney of the Au-injected rat dramatically increased in comparison with Au and Zn content and that Cu-binding MT was predominantly observed in the outer stripe of the outer medulla in the kidney (Saito et al 1997).…”

Localization of the Induced Metallothionein and DNA Damage in Rat Kidney After Gold Injection

“…Although the biological functions of this protein are not fully understood, it is believed to play an important role in the homeostasis of essential metals such as Zn or Cu and in the detoxification of heavy metals such as Cd (Kägi 1993). It has been reported that the content of not only Au but also Cu in renal MT increases after Au treatment in rats (McVety and Shaikh 1987; Saito 1996). Recently we demonstrated that Cu content in the kidney of the Au-injected rat dramatically increased in comparison with Au and Zn content and that Cu-binding MT was predominantly observed in the outer stripe of the outer medulla in the kidney (Saito et al 1997).…”

Localization of the Induced Metallothionein and DNA Damage in Rat Kidney After Gold Injection

“…Although the biological functions of this protein are not fully understood, it is believed to play an important role in the homeostasis of essential metals such as Zn or Cu and in the detoxification of heavy metals such as Cd (Kägi 1993). It has been reported that the content of not only Au but also Cu in renal MT increases after Au treatment in rats (McVety and Shaikh 1987; Saito 1996). Recently we demonstrated that Cu content in the kidney of the Au-injected rat dramatically increased in comparison with Au and Zn content and that Cu-binding MT was predominantly observed in the outer stripe of the outer medulla in the kidney (Saito et al 1997).…”