Subacute Encephalopathy with Seizures in Alcoholics: A Clinical-Electroencephalographic Study

Niedermeyer, E.; Freund, Gerhard; Krumholz, Allan

doi:10.1177/155005948101200304

Cited by 63 publications

(34 citation statements)

References 3 publications

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“…They proposed that this was a unique syndrome occumng in chronic alcohol abusers; it is included in the classification of epileptic syndromes associated with chronic alcoholism (Jallon, 1984). Niedermeyer et al (1981Niedermeyer et al ( , 1987 described chronic alcohol abusers who had a subacute encephalopathy, status epilepticus, and periodic lateralized epileptiform discharges (PLEDs). These patients all recovered, but clinical impairment persisted for several weeks.…”

Section: Subacuteencephalopathyand Chronic Alcoholismmentioning

confidence: 99%

Alcohol, Seizures, and Epilepsy

Hauser

Brust

1988

Epilepsia

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Seizures, epilepsy, and alcohol are complexly interrelated. Although it is commonly perceived that patients with epilepsy experience problems with seizure control if they use alcohol, this is not confirmed by the few experimental studies that have tested the hypothesis. The last 30 years have emphasized the role of withdrawal from alcohol as a mechanism of seizure production. However, this is but one of many potential mechanisms by which seizures and epilepsy may be related to alcohol use and abuse. The rare but clear situations in which alcohol can act as a convulsant drug need further study, and mechanisms by which the long-term neurotoxic effects of alcohol lead to chronic epilepsy also need further elucidation.

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Section: Subacuteencephalopathyand Chronic Alcoholismmentioning

confidence: 99%

Alcohol, Seizures, and Epilepsy

Hauser

Brust

1988

Epilepsia

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“…An unusual picture of subacute encephalopathy with seizures (SESA syndrome) in chronic alcoholics was initially characterized by Niedermeyer et al [1] and Freund and Niedermeyer [2] in 1981. SESA syndrome represents a distinct subtype of localization-related non-convulsive status epilepticus (NCSE) in which recurrent complex partial seizures occur in alcoholic adult individuals, with transient neurologic deficits, interictal periodic lateralized discharges (PLDs) on the electroencephalography (EEG), and chronic multifocal vascular cerebral pathology [3].…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging features in subacute encephalopathy with seizures in alcoholics (SESA syndrome)

Drake-Pérez

Lucas

Lyo

et al. 2016

Seizure

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Purpose To describe the neuroimaging findings in subacute encephalopathy with seizures in alcoholics (SESA syndrome). Methods We reviewed all cases reported previously, as well as 4 patients diagnosed in our center. We included a total of 8 patients. All subjects had clinical and EEG findings compatible with SESA syndrome and at least one MRI study that did not show other underlying condition that could be responsible for the clinical presentation. Results Initial MRI studies revealed the following features: cortical-subcortical areas of increased T2/FLAIR signal and restricted diffusion (6 patients), hyperperfusion (3 patients), atrophy (5 patients), chronic microvascular ischemic changes (4 patients). Follow-up MRI was performed in half of the patients, all showing a resolution of the hyperintense lesions, but developing focal atrophic changes in 75%. Conclusions SESA syndrome should be included among the alcohol-related encephalopathies. Its radiological features include transient cortical-subcortical T2-hyperintense areas with restricted diffusion (overlapping the typical findings in status epilepticus) observed in a patient with atrophy and chronic multifocal vascular lesions.

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“…There are documented cases that support the idea that alcohol can have a convulsant effect, which should be considered in the diagnosis and treatment of patients with ethanol use and seizuresat patients without a history of epilepsy or ethanol withdrawal, who have seizures at the time of consumption, even at moderate amounts or without reaching ethanol poisoning.  Niedermeyer 15 defined the "subacute encephalopathy with seizures" in chronic alcoholism = a particular state of postictal somnolence in alcoholics  A clear differentiation between subacute encephalopathy with seizures and ethanol withdrawal can sometimes be difficult in alcoholic epileptic patients.…”

Section: Clinical Exammentioning

confidence: 99%

Alcohol – Epilepsy comorbidity. Evolution aspects and therapeutic approaches

2020

JCBSC

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The prevalence of epilepsy in alcoholic patients is three times more than the general population, and alcoholism is more prevalent among patients with epilepsy. The incidence of complications, therapeutic and evolutionary particularities become important. A meta-analysis of the recent literature, in which alcohol is just one of the other factors involved in seizures, along with head traumas, stroke, metabolic effects, etc. Withdrawal can cause seizures, along with the direct neurotoxic effects of antipsychotics, antidepressants or brain stimuli. 4-7% of alcoholic patients have epileptic seizures. Withdrawal occurs after repeated episodes of consumption. There is a significant association between cortical atrophy and the duration of consumption, which causes a higher risk for seizures. Alcoholics more prone to seizures are: older, with long periods of intoxication, with brain atrophy, neurological signs and history of previous seizures. Antiepileptic medication is indicated after at least two clonic-tonic seizures developed in the absence of withdrawal. The duration of alcohol consumption should be over 12 years to reach epileptic seizures and in the absence of withdrawal. There is a dose-response relationship depending on the daily amount of alcohol consumption, which determines Alcohol-Epilepsy… Simona Trifu et al.

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Subacute Encephalopathy with Seizures in Alcoholics: A Clinical-Electroencephalographic Study

Abstract: Downloaded fromo r-Z a TABLE 2 > r-PATIENT MATERIAL AND MOST RELEVANT DATA m r-m NEUROLOGICAL o -t COURSE DEFICITS SEIZURES EEG :xl 0 m Case 1, B. One subacute episode Korsakov, bilateral Grand mal. Slowing and spiking over left fronto-

Cited by 63 publications

References 3 publications

Alcohol, Seizures, and Epilepsy

Alcohol, Seizures, and Epilepsy

Neuroimaging features in subacute encephalopathy with seizures in alcoholics (SESA syndrome)

Alcohol – Epilepsy comorbidity. Evolution aspects and therapeutic approaches

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