volume 93, issue 0, P2-P-190 2020
DOI: 10.1254/jpssuppl.93.0_2-p-190
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Abstract: Oxidative stress has been implicated in the progression of neurodegenerative disorders, including Parkinson's disease. We have previously demonstrated that noradrenaline increases the level of intracellular glutathione (GSH) in astrocytes via β 3-adrenoceptor stimulation and protects co-cultured neurons from oxidative stress-induced death by increasing the supply of GSH from astrocytes. In addition, we have reported that the intraperitoneal administration of SR58611A, a β 3-adrenoceptor agonist, increases the …

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