Su1994 – The Common Food Additives Sodium Sulfite and Polysorbate 80 Have a Profound Inhibatory Effect on the Commensal, Anti-Inflammatory Bacterium Faecalibacterium Prausnitzii. the Enigma Study

Loayza, Jeimy Johana Jimenez; Berendsen, Erwin M.; Teh, Jing-Jie; Hoedt, Emily C.; Jing-wan, Zhang; Qin, Liu; Hamilton, Amy L.; Wilson-O’Brien, Amy; Trakman, Gina L.; Lin, Weitao; Tang, Whitney; Ching, Jessica; Or, Leo; Sung, Joseph J.; Yu, Jun; Ng, Siew C.; Kamm, Michael A.; Morrison, Mark

doi:10.1016/s0016-5085(19)38628-7

Cited by 2 publications

(5 citation statements)

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“…V amanu et al, investigated the alteration of human intestinal floras through a vitro static system called GIS1 and revealed similar results, with decreases in the beneficial bacteria such as Bifidobacterium genus and increases in the possibly pathogenic bacteria Enterococcaceae genus [ 65 ]. The growth of bile-tolerant microorganisms Bilophila genus, the anti-inflammatory bacteria Faecalibacterium prausnitzii and two species from the Bacteroides genus ( Bacteroides fragilis and Bacteroides uniformis ) were inhibited after culturing with sucralose in vitro [ 17 , 26 , 92 , 93 ].…”

Section: Artificial Sweetenersmentioning

confidence: 99%

“…Additionally, the growth of Faecalibacterium prausnitzii and the E . coli strains HB101 and K-12 were also reduced [ 26 , 92 ].…”

Section: Artificial Sweetenersmentioning

confidence: 99%

“…At the genus level, the content of beneficial bacteria Faecalibacterium , as well as pathogenic bacteria Aeromonas and Methylobacterium, demonstrated a significant downward trend [ 172 ]. In vitro, the growth of Faecalibacterium prausnitzi also significantly decreased after treatment with PS [ 92 ]. Moreover, most of the susceptible bacteria are Gram-negative after PS exposure.…”

Section: Preservativesmentioning

confidence: 99%

“…Sodium sulfite (SS) is one of the most common food preservatives among them. It strongly inhibited the growth of Faecalibacterium prausnitzii [ 92 ]. Lactobacillus casei , Lactobacillus rhamnosus and Lactobacillus plantarum , considered as beneficial gut bacteria for their ability to produce lactic acid, were also reduced [ 173 ].…”

Section: Preservativesmentioning

confidence: 99%

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Food Additives Associated with Gut Microbiota Alterations in Inflammatory Bowel Disease: Friends or Enemies?

et al. 2022

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During the 21st century, the incidence and prevalence of inflammatory bowel disease (IBD) is rising globally. Despite the pathogenesis of IBD remaining largely unclear, the interactions between environmental exposure, host genetics and immune response contribute to the occurrence and development of this disease. Growing evidence implicates that food additives might be closely related to IBD, but the involved molecular mechanisms are still poorly understood. Food additives may be categorized as distinct types in accordance with their function and property, including artificial sweeteners, preservatives, food colorant, emulsifiers, stabilizers, thickeners and so on. Various kinds of food additives play a role in modifying the interaction between gut microbiota and intestinal inflammation. Therefore, this review comprehensively synthesizes the current evidence on the interplay between different food additives and gut microbiome alterations, and further elucidates the potential mechanisms of food additives–associated microbiota changes involved in IBD.

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Section: Artificial Sweetenersmentioning

confidence: 99%

“…Additionally, the growth of Faecalibacterium prausnitzii and the E . coli strains HB101 and K-12 were also reduced [ 26 , 92 ].…”

Section: Artificial Sweetenersmentioning

confidence: 99%

Section: Preservativesmentioning

confidence: 99%

Section: Preservativesmentioning

confidence: 99%

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Food Additives Associated with Gut Microbiota Alterations in Inflammatory Bowel Disease: Friends or Enemies?

et al. 2022

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“…Emulsifiers commonly used in ultra‐processed food have been shown in animal studies to destroy the protective enteric mucous layer, through effects on the gut microbiota 27 . In vitro studies examining a range of food additives have demonstrated that they can diminish the abundance and viability of protective gut organisms, such as Faecalibacterium prausnitzii , and enhance the abundance and pathogenic activity of pro‐inflammatory organisms, such as Proteus spp 28 …”

Section: Inflammatory Bowel Diseasesmentioning

confidence: 99%

The gut microbiota and gut disease

Fehily

Basnayake

Wright

et al. 2021

Internal Medicine Journal

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The gut microbiota has a key role in the maintenance of good health, and in the pathogenesis of gastrointestinal diseases. These conditions include the inflammatory bowel diseases, colorectal cancer, coeliac disease and metabolic liver disease. Although the nature of the microbial disturbance in these conditions has not been fully characterised, this has not prevented the development of microbially based therapies. Microbial‐changing therapies may address newly recognised pathophysiological contributors of disease and have the potential to replace or supplement standard therapies. Antibiotics play a role in initial Clostridiodes difficile disease and some specific inflammatory disorders. Probiotics have a more limited proven role. Faecal microbiota transplantation is of proven therapeutic benefit in recurrent C. difficile disease and ulcerative colitis. We review the current literature for microbiota‐targeted therapies in gut disorders.

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Su1994 – The Common Food Additives Sodium Sulfite and Polysorbate 80 Have a Profound Inhibatory Effect on the Commensal, Anti-Inflammatory Bacterium Faecalibacterium Prausnitzii. the Enigma Study

Cited by 2 publications

References 0 publications

Food Additives Associated with Gut Microbiota Alterations in Inflammatory Bowel Disease: Friends or Enemies?

Food Additives Associated with Gut Microbiota Alterations in Inflammatory Bowel Disease: Friends or Enemies?

The gut microbiota and gut disease

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