Studying tautomerism in an important pharmaceutical glibenclamide confined in the thin nanometric layers

A to Z of polymorphs related by proton transfer

“…23 For absolute confidence in crystal structure determination of complex systems, especially for molecules capable of tautomerism or materials for which proton positions are critical, orthogonal techniques such as neutron diffraction, solid state nuclear magnetic resonance (ssNMR) and infrared spectroscopy can be used to re-confirm assignment of proton positions. 22,[24][25][26][27] Emerging techniques such as near-edge X-ray absorption fine structure spectroscopy (NEXAFS), in combination with density functional theory (DFT), have also been used to confirm exact H-atom positions in salt-cocrystal systems. 28 DFT can be used to calculate the relative stability of tautomers and to predict the effect of different solvents on their equilibrium.…”

Broadband Mueller ellipsometer as an all-in-one tool for spectral and temporal analysis of mutarotation kinetics

“…25 Moreover, fast and precise response makes MMSE widely popular as an in situ control 26,27 capable of real-time tracking of dynamic processes. This has been done very sparsely in chemical kinetics, 28 and only once regarding glucose mutarotation, 29 despite being fundamental to saccharides. Considering that the used method is monochromatic and does not account for glucose gyration spectra, it leaves much room for improvement, where MMSE appears to be a hot candidate.…”

Role of Self-Assembled Surface Functionalization on Nucleation Kinetics and Oriented Crystallization of a Small-Molecule Drug: Batch and Thin-Film Growth of Aspirin as a Case Study

“…The ability of selected substrates to modify the structural order of materials near the interface was exploited to study thin-film phases . Thin films of pharmaceuticals were prepared to enhance the drug solubility and dissolution rate, discover new polymorphs, , control the nucleation of specific crystal forms and stabilize amorphous forms, alter the texture and form of crystals by coupling them with thermal treatments, study tautomerism, and the crystallization behavior of drugs in different solvents and with polymeric additives . For example, aspirin (ASA) deposited on oriented pyrolytic graphite by spin coating led to dimer rods reflecting the underlying pattern as a result of nonpolar interactions .…”