Study on the mechanism of Orthosiphon aristatus (Blume) Miq. in the treatment of hyperuricemia by microbiome combined with metabonomics

Zhu, Chunsheng; Niu, Hongjuan; Bian, Meng; Zhang, Xiaochuan; Zhang, Xiaomeng; Zhou, Zhiyuan

doi:10.1016/j.jep.2023.116805

Cited by 6 publications

(3 citation statements)

References 54 publications

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“…Previous studies have emphasized the changes of the gut microbiota and their metabolites in the context of improving hyperuricemia. 46,47 In this study, analysis of the cecum contents further demonstrated that EGCG altered the metabolic profile of the gut microbiota (Fig. 4).…”

Section: Discussionsupporting

confidence: 58%

Mechanisms of epigallocatechin gallate (EGCG) in ameliorating hyperuricemia: insights into gut microbiota and intestinal function in a mouse model

Yu,

Lou,

et al. 2024

Food Funct.

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Section: Discussionsupporting

confidence: 58%

Mechanisms of epigallocatechin gallate (EGCG) in ameliorating hyperuricemia: insights into gut microbiota and intestinal function in a mouse model

Yu,

Lou,

et al. 2024

Food Funct.

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“…The serum processing method and instrument details in the untargeted metabolomics analysis are reported in our previous literature ( Zhu et al, 2023 ). The mobile phase was a mixture of solvent A (acetonitrile) and solvent B (water containing 25 mM ammonium acetate and 25 mM ammonium hydroxide) at a flow rate of 0.5 mL/min.…”

Section: Methodsmentioning

confidence: 99%

“…Orthosiphon aristatus (Blume) Miq., also known as kidney tea, is a perennial herb belonging to the family Lamiaceae ( Zhu et al, 2023 ). Kidney tea is recorded in the traditional Dai medical works “Bei Ye Jing” and “Dang Haya,” and has been used for more than 2,000 years.…”

Section: Introductionmentioning

confidence: 99%

Kidney tea [Orthosiphon aristatus (Blume) Miq.] improves diabetic nephropathy via regulating gut microbiota and ferroptosis

Zhou,

Niu,

Bian

et al. 2024

Front. Pharmacol.

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IntroductionDiabetic nephropathy (DN) is the leading cause of end-stage renal disease. Due to its complex pathogenesis, new therapeutic agents are urgently needed. Orthosiphon aristatus (Blume) Miq., commonly known as kidney tea, is widely used in DN treatment in China. However, the mechanisms have not been fully elucidated.MethodsWe used db/db mice as the DN model and evaluated the efficacy of kidney tea in DN treatment by measuring fasting blood glucose (FBG), serum inflammatory cytokines, renal injury indicators and histopathological changes. Furthermore, 16S rDNA gene sequencing, untargeted serum metabolomics, electron microscope, ELISA, qRT-PCR, and Western blotting were performed to explore the mechanisms by which kidney tea exerted therapeutic effects.ResultsTwelve polyphenols were identified from kidney tea, and its extract ameliorated FBG, inflammation and renal injury in DN mice. Moreover, kidney tea reshaped the gut microbiota, reduced the abundance of Muribaculaceae, Lachnoclostridium, Prevotellaceae_UCG-001, Corynebacterium and Akkermansia, and enriched the abundance of Alloprevotella, Blautia and Lachnospiraceae_NK4A136_group. Kidney tea altered the levels of serum metabolites in pathways such as ferroptosis, arginine biosynthesis and mTOR signaling pathway. Importantly, kidney tea improved mitochondrial damage, increased SOD activity, and decreased the levels of MDA and 4-HNE in the renal tissues of DN mice. Meanwhile, this functional tea upregulated GPX4 and FTH1 expression and downregulated ACSL4 and NCOA4 expression, indicating that it could inhibit ferroptosis in the kidneys.ConclusionOur findings imply that kidney tea can attenuate DN development by modulating gut microbiota and ferroptosis, which presents a novel scientific rationale for the clinical application of kidney tea.

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Spike lavender essential oil attenuates hyperuricemia and induced renal injury by modulating the TLR4/NF-κB/NLRP3 signalling pathway

Zhou,

Zhang,

Wang

et al. 2024

Arabian Journal of Chemistry

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Study on the mechanism of Orthosiphon aristatus (Blume) Miq. in the treatment of hyperuricemia by microbiome combined with metabonomics

Cited by 6 publications

References 54 publications

Mechanisms of epigallocatechin gallate (EGCG) in ameliorating hyperuricemia: insights into gut microbiota and intestinal function in a mouse model

Mechanisms of epigallocatechin gallate (EGCG) in ameliorating hyperuricemia: insights into gut microbiota and intestinal function in a mouse model

Kidney tea [Orthosiphon aristatus (Blume) Miq.] improves diabetic nephropathy via regulating gut microbiota and ferroptosis

Spike lavender essential oil attenuates hyperuricemia and induced renal injury by modulating the TLR4/NF-κB/NLRP3 signalling pathway

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