Study on the interaction between DNA and protein induced by anticancer drug carboplatin

Liu, Shanchao; Liu, Yingju; Li, Jia; Guo, Minzhe; Yao, Shouzhuo

doi:10.1016/j.jbbm.2005.04.001

Cited by 9 publications

(3 citation statements)

References 30 publications

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“…The interaction of DNA and human serum albumin (HSA) in the presence of the anticancer drug carboplatin was studied with piezoelectric quartz crystal impedance (PQCI) and electrochemical techniques by Liu et al. 11. Zhou et al.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Mitomycin C with DNA Immobilized onto Single‐walled Carbon Nanotube/Polymer Modified Pencil Graphite Electrode

Canavar¹,

Kuralay²,

Erdem³

2011

Electroanalysis

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The electrochemical investigation of the interaction between the anticancer drug mitomycin C (MC) and DNA was described using a single-walled carbon nanotube (SWCNT)/poly(vinylferrocenium) (PVF + ) modified pencil graphite electrode (PGE). The electrochemical oxidation signals of guanine were monitored before and after the interaction between MC and DNA by using differential pulse voltammetry. The effects of DNA and MC concentration and MC interaction time were examined based on the electrode response. Cyclic voltammetry and electrochemical impedance spectroscopy were used for the characterization of SWCNT/PVF + modified and PVF + modified PGEs. The detection limit corresponded to 625 ng/mL for MC using calf thymus double-stranded DNA immobilized SWCNT/PVF + modified PGE.

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Section: Introductionmentioning

confidence: 99%

Interaction of Mitomycin C with DNA Immobilized onto Single‐walled Carbon Nanotube/Polymer Modified Pencil Graphite Electrode

Canavar¹,

Kuralay²,

Erdem³

2011

Electroanalysis

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“…They provide novel platforms for improving specific activity and affinity of biomolecular probes (DNA, enzyme or antibody-antigen) by increasing the surface density of the respective biomolecular probes on the electrodes and catalyzing the subsequent biochemical reactions [64]. Besides, nanoparticles are generally stable, cheap, and more flexible.…”

Section: General Overviewmentioning

confidence: 99%

“…Typical array of nanoplatforms for biosensor designs are shown in Figure 6. In general, nanoparticles can be linked to electrode surfaces through self-assembled monolayer (SAM) possessing functional groups like SH, NH 2 or CN at their open ends [61,64]. Overall, immunosensors are the most studied impedimetric biosensors followed by DNA biosensors and lastly enzyme biosensors.…”

Section: General Overviewmentioning

confidence: 99%

Impedance Spectroscopy: A Powerful Tool for Rapid Biomolecular Screening and Cell Culture Monitoring

2005

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Dielectric spectroscopy or Electrochemical impedance spectroscopy (EIS) is traditionally used in corrosion monitoring, coatings evaluation, batteries, and electrodeposition and semiconductor characterization. However, in recent years, it is gaining widespread application in biotechnology, tissue engineering, and characterization of biological cells, disease diagnosis and cell culture monitoring. This article discusses the principles and implementation of dielectric spectroscopy in these bioanalytical applications. It provides examples of EIS as label-free, mediator-free strategies for rapid screening of biocompatible surfaces, monitoring pathogenic bacteria, as well as the analysis of heterogeneous systems, especially biological cells and tissues. Descriptions are given of the application of nanoparticles to improve the analytical sensitivities in EIS. Specific examples are given of the detection of base pair mismatches in the DNA sequence of Hepatitis B disease, TaySachs disease and Microcystis spp. Others include the EIS detection of viable pathogenic bacteria and the influence of nanomaterials in enhancing biosensor performance. Expanding applications in tissue engineering such as adsorption of proteins onto thiolated hexa(-ethylene glycol)-terminated (EG6) self-assembled monolayer (SAM) are discussed.

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Acoustic microsensors—the challenge behind microgravimetry

2005

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Acoustic microsensors are commonly known as high-resolution mass-sensitive devices. This is a restricted view in many chemical and biosensor applications, especially in liquids. Sensitivity to non-gravimetric effects is a challenging feature of acoustic sensors. In this review we give an overview of recent developments in resonant sensors including micromachined devices and also list recent activity relating to the (bio)chemical interface of acoustic sensors. Major results from theoretical analysis of quartz crystal resonators, descriptive for all acoustic microsensors are summarized, and non-gravimetric contributions to the sensor signal from viscoelasticity and interfacial effects are discussed. We finally conclude with some future perspectives.

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Study on the interaction between DNA and protein induced by anticancer drug carboplatin

Cited by 9 publications

References 30 publications

Interaction of Mitomycin C with DNA Immobilized onto Single‐walled Carbon Nanotube/Polymer Modified Pencil Graphite Electrode

Interaction of Mitomycin C with DNA Immobilized onto Single‐walled Carbon Nanotube/Polymer Modified Pencil Graphite Electrode

Impedance Spectroscopy: A Powerful Tool for Rapid Biomolecular Screening and Cell Culture Monitoring

Acoustic microsensors—the challenge behind microgravimetry

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