Study on the characteristic of intestinal flora in patients with dual antiplatelet therapy

Chao, Guanqun; Ye, Fangxu; Shen, Wei; Gong, Wenqian; Zhang, Shuo

doi:10.1080/1061186x.2019.1681433

Cited by 4 publications

(5 citation statements)

References 32 publications

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“…In line with our study, a recent animal study demonstrated that stool samples from mice fed with aspirin had an increase in anti‐inflammatory bacteria and reduction in pro‐inflammatory bacteria 3 . Also consistent with our findings, a recent cross‐sectional study did not detect a difference in microbiome diversity, but did find a difference in individual taxa in 20 individuals who did and did not receive combined anti‐platelet treatment including aspirin and clopidogrel 4 …”

supporting

confidence: 93%

“…3 Also consistent with our findings, a recent cross-sectional study did not detect a difference in microbiome diversity, but did find a difference in individual taxa in 20 individuals who did and did not receive combined anti-platelet treatment including aspirin and clopidogrel. 4 We agree that some observed changes in our study might be explained by diet or use of drugs, other than aspirin, due to the differential changes in aspirin and placebo arms during intervention.…”

Section: N V I T E D E D I T O R I a L Editorial: The Microbiome Asupporting

confidence: 79%

“…To view these articles, visit https://doi.org/10.1111/apt.16013 and https://doi.org/10.1111/apt.16071 Anna E. Prizment 1,2 Guillaume Onyeaghala 3 Timothy R. Church 2,4…”

Section: N K Ed Co Ntentmentioning

confidence: 99%

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Editorial: the microbiome, aspirin and colorectal cancer—authors' reply

Prizment

Onyeaghala

2020

Aliment Pharmacol Ther

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supporting

confidence: 93%

Section: N V I T E D E D I T O R I a L Editorial: The Microbiome Asupporting

confidence: 79%

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Editorial: the microbiome, aspirin and colorectal cancer—authors' reply

Prizment

Onyeaghala

2020

Aliment Pharmacol Ther

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“…www.nature.com/scientificreports/ In addition to aspirin use, our study revealed that taking clopidogrel reduced the risk of KP-PLA. Chao et al found that taking aspirin and clopidogrel for 1-12 months could change the intestinal flora; the number of Lactobacillales and Lactobacillaceae within the flora increased at the order level and family level, respectively 23 . The development of KP-PLA is associated with changes in the gut microbiota, especially a reduction in the Lactobacillales and Lactobacillaceae flora 24 .…”

Section: Discussionmentioning

confidence: 99%

The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients

Tai

Hsu

Yang

et al. 2020

Sci Rep

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In this study, we aimed to investigate the impact of aspirin on the risk of pyogenic liver abscess caused by Klebsiella pneumoniae (KP-PLA) and invasive KP-PLA syndrome (IKPS) in diabetic patients. Diabetic patients who were propensity-score matched were retrospectively included from hospital-based database. Kaplan–Meier approach with a log-rank test was used to compare the cumulative incidences of KP-PLA including IKPS between aspirin users and non-users. Totally, 63,500 patients were analyzed after propensity-score matching (1:1). Compared with that of non-users, the incidence of KP-PLA was significantly reduced in aspirin users (0.31% vs. 0.50%, p < 0.01), but not for that of IKPS (0.02% vs. 0.03%, p = 0.29). Patients taking aspirin for ≥ 90 days had a significantly lower risk for KP-PLA (hazard ratio, 0.67; 95%CI, 0.50–0.90). Females, taking clopidogrel or metformin for ≥ 90 days, and taking H2-blockers or proton pump inhibitors (PPIs) for ≥ 5 days were also associated with a lower risk of KP-PLA. However, cholangitis and a glycated hemoglobin ≥ 8.5% were associated with an increased risk of KP-PLA.

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“…Thus, rifaximin-EIR treatment significantly inhibits the intestinal injury induced by indomethacin, and this intestinal protective effect is associated with reduced tissue inflammation, oxidative stress and gastrointestinal bleeding, and the reversal of bacterial population changes caused by NSAIDs [5,19]. In a human trial of dual antiplatelet therapy (DAPT), the intestinal flora of the aspirin and clopidogrel group was significantly different from that of the control group at the class, order, family, and genus levels, although DAPT did not cause changes in the biodiversity of the intestinal flora [20]. The DAPT group showed a higher abundance of Bacilli and a lower abundance of Erysipelotrichia at the class level; a higher abundance of Lactobacillales and lower abundance of Erysipelotrichales at the order level; a higher abundance of Streptococcaceae and Lactobacillaceae and a lower abundance of Acidaminococcaceae and Erysipelotrichaceae at the family level; and a higher abundance of Streptococcus and Klebsiella and a lower abundance of Blautia, Phascolarctobacterium, and Megamonas at the genus level.…”

Section: Discussionmentioning

confidence: 99%

Fecal 16S rRNA Gene Sequencing Analysis of Changes in the Gut Microbiota of Rats with Low-Dose Aspirin-Related Intestinal Injury

Chi

Zhao

Wang

2021

BioMed Research International

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Background. The incidence of small intestinal injury caused by low-dose aspirin (LDA) is high, but the pathogenesis and intervention measures of it have not been elucidated. Recent studies have found gut microbiota to be closely associated with onset and development of NSAID-induced intestinal injury. However, studies of the changes in the gut microbiota of rats with LDA-related intestinal injury have been lacking recently. In this study, we investigated fecal 16S rRNA gene sequencing analysis of changes in the gut microbiota of rats with LDA-related intestinal injury. Methods. Sprague-Dawley (SD) rat models of small intestinal injury were established by intragastric administration of LDA. The small intestinal tissues and the fecal samples were harvested. The fecal samples were then analyzed using high-throughput sequencing of 16S rRNA V3-V4 amplicons. The gut microbiota composition and diversity were analyzed and compared using principal coordinate analysis (PCoA), nonmetric multidimensional scaling (NMDS) analysis, the unweighted pair-group method with arithmetic mean (UPGMA) clustering analysis, multivariate statistical analysis (ANOSIM, MetaStats, and LEfSe), and spatial statistics. Results. The LDA rat model was successfully established. Decreased Firmicutes and increased Bacteroidetes abundances in rats with LDA-induced small intestinal injury were revealed. MetaStats analysis between the before administration of LDA (CG) and after administration of LDA (APC) groups showed that the intestinal floras exhibiting significant differences ( P < 0.05 , q < 0.1 ) were Firmicutes, Bacteroides, Cyanobacteria, Melainabacteria, Coriobacteriia, Bacteroidia, Bacteroidales, Eubacteriaceae, and Streptococcaceae. In addition, the bacterial taxa showing significant differences between the control (NS) and APC groups were Firmicutes, Bacteroides, Verrucomicrobiaceae and Peptococcaceae. Conclusions. The alterations in the gut microbiota composition and diversity of rats with LDA-related intestinal injury were found in the present study. The change of gut microbiota in LDA-related intestinal injury will lay the foundation for further research on the function and signaling pathways of the intestinal flora and promote the use of intestinal flora as drug targets to treat LDA-induced small intestinal injury.

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Study on the characteristic of intestinal flora in patients with dual antiplatelet therapy

Cited by 4 publications

References 32 publications

Editorial: the microbiome, aspirin and colorectal cancer—authors' reply

Editorial: the microbiome, aspirin and colorectal cancer—authors' reply

The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients

Fecal 16S rRNA Gene Sequencing Analysis of Changes in the Gut Microbiota of Rats with Low-Dose Aspirin-Related Intestinal Injury

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