Study on the behavioral changes of a post-stroke depression rat model

Wu, Chunfang; Zhang, Junhe; Chen, Yong

doi:10.3892/etm.2015.2450

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…Studies with stroke model that analyzed the vertical and horizontal movements after brain lesion using open field test reported a reduction of locomotor activity at 3, 7, and 14 days after ischemic induction by comparing all experimental groups to basal time, but in ischemic groups the significant results indicated motor impairment deficit with habituation effect [ 52 – 54 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of temperature induction in focal ischemic thermocoagulation model

et al. 2018

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The thermocoagulation model, which consists of focal cerebral ischemia with craniectomy, is helpful in studying permanent ischemic brain lesions and has good reproducibility and low mortality. This study analyzed the best conditions for inducing a focal ischemic lesion by thermocoagulation. We investigated parameters such as temperature and thermal dissipation in the brain tissue during induction and analyzed real-time blood perfusion, histological changes, magnetic resonance imaging (MRI), and motor behavior in a permanent ischemic stroke model. We used three-month-old male Wistar rats, weighing 300–350 g. In the first experiment, the animals were divided into four groups (n = 5 each): one sham surgery group and three ischemic lesion groups having thermocoagulation induction (TCI) temperatures of 200°C, 300°C, and 400°C, respectively, with blood perfusion (basal and 30 min after TCI) and 2,3,5-Triphenyl-tetrazolium chloride (TTC) evaluation at 2 h after TCI. In the second experiment, five groups (n = 5 each) were analyzed by MRI (basal and 24 h after TCI) and behavioral tests (basal and seven days after TCI) with the control group added for the surgical effects. The MRI and TTC analyses revealed that ischemic brain lesions expressively evolved, especially at TCI temperatures of 300°C and 400°C, and significant motor deficits were observed as the animals showed a decrease frequency of movement and an asymmetric pattern. We conclude that a TCI temperature of 400°C causes permanent ischemic stroke and motor deficit.

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Section: Discussionmentioning

confidence: 99%

Evaluation of temperature induction in focal ischemic thermocoagulation model

et al. 2018

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“…Moreover, disruption of biogenic monoamine neurotransmission in PSD can be correlated to behavioral changes in animal models. Specifically, Wu and colleagues (2015) showed increased immobility in the Forced Swim test, decreased mobility in the Open Field test, and decreased sucrose consumption in the Sucrose Preference test in a rat model of PSD, which are all indices of enhanced anxiety-like and depressive-like phenotypes in rodents.…”

Section: Behavioral Sequela Secondary To Stroke-related Executive Dysmentioning

confidence: 96%

Executive (dys)function after stroke: special considerations for behavioral pharmacology

Povroznik¹,

Ozga

Haar

et al. 2018

Behavioural Pharmacology

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Stroke is a worldwide leading cause of death and long-term disability with concurrent secondary consequences that are largely comprised of mood dysfunction, as well as sensory, motor, and cognitive deficits. This review focuses on the cognitive deficits associated with stroke specific to executive dysfunction (including decision making, working memory, and cognitive flexibility) in humans, nonhuman primates, and additional animal models. Further, we review some of the cellular and molecular underpinnings of the individual components of executive dysfunction and their neuroanatomical substrates after stroke, with an emphasis on the changes that occur during biogenic monoamine neurotransmission. We concentrate primarily on changes in the catecholaminergic (dopaminergic and noradrenergic) and serotonergic systems at the levels of neurotransmitter synthesis, distribution, reuptake, and degradation. We also discuss potential secondary stroke-related behavioral deficits (specifically, poststroke depression as well as drug-abuse potential and addiction) and their relationship with stroke-induced deficits in executive function, an especially important consideration given that the average age of the human stroke population is decreasing. In the final sections, we address pharmacological considerations for the treatment of ischemia and the subsequent functional impairment, as well as current limitations in the field of stroke and executive function research.

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“…PSD complicates the outcome of stroke recovery, further exacerbates the physical and psychological symptoms, lowers the quality of patients' life and increases the recurrence rate and mortality of stroke ( 9 ). Symptoms of PSD include sad mood, slowness in thoughts and emotions, loss of appetite and burnout, and also involve hopelessness, irritability, and sleep problems ( 10 ). Patients with PSD have a higher risk of subsequent mortality compared with non-depressed stroke patients.…”

Section: Introductionmentioning

confidence: 99%

Resilience as the Mediating Factor in the Relationship Between Sleep Disturbance and Post-stroke Depression of Stroke Patients in China: A Structural Equation Modeling Analysis

et al. 2021

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Background: Stroke patients may suffer from a variety of symptoms which can result in sleep disturbance and post-stroke depression (PSD). Whereas, resilience can alleviate sleep disturbance and help maintain well-being after stroke.Objective: The aim of this study is to explore whether resilience plays a mediating role in the relationship between sleep disturbance and PSD of stroke patients in China.Methods: A cross-sectional study with a multi-stage sampling was carried out in Liaoning Rehabilitation Center and the Third People's Hospital of Chongqing in China from May to September 2019. A total of 353 stroke patients were enrolled in this study. Structural equation model (SEM) was used to test the mediating effect of resilience on the relationship between sleep disturbance and PSD.Results: The prevalence of PSD of stroke patients was 34.56%. Sleep disturbance contributed most to the variance of PSD and had a significantly positive association with PSD among stroke patients (P < 0.01). Resilience was negatively associated with PSD, and acted as a mediator between sleep disturbance and PSD (a * b = 0.201, BCa 95% CI: 0.156~0.254).Conclusions: The prevalence of PSD was high among the Chinese stroke patients. Sleep disturbance was highly associated with PSD, resulting in the increased risk of PSD. Furthermore, resilience has a mediating effect on the relationship between sleep disturbance and PSD, and could reduce the negative effect of sleep disturbance on the development of PSD.

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Study on the behavioral changes of a post-stroke depression rat model

Cited by 10 publications

References 25 publications

Evaluation of temperature induction in focal ischemic thermocoagulation model

Evaluation of temperature induction in focal ischemic thermocoagulation model

Executive (dys)function after stroke: special considerations for behavioral pharmacology

Resilience as the Mediating Factor in the Relationship Between Sleep Disturbance and Post-stroke Depression of Stroke Patients in China: A Structural Equation Modeling Analysis

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