Study on identification of a three-microRNA panel in serum for diagnosing neonatal early onset sepsis

Zhao, Yihong; Lu, Chong; Zhu, Ruqin; Hu, Xiaoyan

doi:10.1080/14767058.2023.2280527

Cited by 3 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to recently published results, a three-miRNA panel (miR-15a-5p, miR-16-5p and miR-223-3p) may be applied as a noninvasive marker for early onset sepsis of neonates [95], whereas miR-519c-5p and miR-3622b-3p were identified as novel biomarkers of sepsis in adult patients [96]. Furthermore, evaluation of serum miR-155 expression can be utilized as a novel marker for septic acute kidney injury (AKI) [97].…”

Section: Mirna Biomarkers In Sepsismentioning

confidence: 99%

Role of microRNAs in Immune Regulation with Translational and Clinical Applications

Gaál

2024

IJMS

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are 19–23 nucleotide long, evolutionarily conserved noncoding RNA molecules that regulate gene expression at the post-transcriptional level. In this review, involvement of miRNAs is summarized in the differentiation and function of immune cells, in anti-infective immune responses, immunodeficiencies and autoimmune diseases. Roles of miRNAs in anticancer immunity and in the transplantation of solid organs and hematopoietic stem cells are also discussed. Major focus is put on the translational clinical applications of miRNAs, including the establishment of noninvasive biomarkers for differential diagnosis and prediction of prognosis. Patient selection and response prediction to biological therapy is one of the most promising fields of application. Replacement or inhibition of miRNAs has enormous therapeutic potential, with constantly expanding possibilities. Although important challenges still await solutions, evaluation of miRNA fingerprints may contribute to an increasingly personalized management of immune dysregulation with a remarkable reduction in toxicity and treatment side effects. More detailed knowledge of the molecular effects of physical exercise and nutrition on the immune system may facilitate self-tailored lifestyle recommendations and advances in prevention.

show abstract

Section: Mirna Biomarkers In Sepsismentioning

confidence: 99%

Role of microRNAs in Immune Regulation with Translational and Clinical Applications

Gaál

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Post-transcriptional regulation involving various miRNAs plays a role in the pathophysiology of sepsis [50]. Consequently, numerous studies have explored their potential as diagnostic biomarkers in EOS [51][52][53][54][55][56][57]. Although not able to detect microorganisms directly, they have been studied for their diagnostic accuracy and potential utility as diagnostic markers for EOS.…”

Section: Micrornas In Eosmentioning

confidence: 99%

“…miR-15a and miR-16 emerged as crucial diagnostic biomarkers for neonatal sepsis [62]. Zhao et al found moderate diagnostic value for miR-15a-5p and miR-16-5p in EOS [56], suggesting their involvement in the inflammatory process by activating the NF-κB pathway and targeting TNIP2 [63]. A Study by Fouda et al highlighted the significance of miR-15b and miR-378a, demonstrating their potential as discriminators of sepsis, with high sensitivity and specificity [55].…”

Section: Micrornas In Eosmentioning

confidence: 99%

See 1 more Smart Citation

Application of Advanced Molecular Methods to Study Early-Onset Neonatal Sepsis

Kosmeri,

Giapros,

Serbis

et al. 2024

IJMS

View full text Add to dashboard Cite

Early-onset sepsis (EOS) is a global health issue, considered one of the primary causes of neonatal mortality. Diagnosis of EOS is challenging because its clinical signs are nonspecific, and blood culture, which is the current gold-standard diagnostic tool, has low sensitivity. Commonly used biomarkers for sepsis diagnosis, including C-reactive protein, procalcitonin, and interleukin-6, lack specificity for infection. Due to the disadvantages of blood culture and other common biomarkers, ongoing efforts are directed towards identifying innovative molecular approaches to diagnose neonates at risk of sepsis. This review aims to gather knowledge and recent research on these emerging molecular methods. PCR-based techniques and unrestricted techniques based on 16S rRNA sequencing and 16S–23S rRNA gene interspace region sequencing offer several advantages. Despite their potential, these approaches are not able to replace blood cultures due to several limitations; however, they may prove valuable as complementary tests in neonatal sepsis diagnosis. Several microRNAs have been evaluated and have been proposed as diagnostic biomarkers in EOS. T2 magnetic resonance and bioinformatic analysis have proposed potential biomarkers of neonatal sepsis, though further studies are essential to validate these findings.

show abstract

Bioinformatics in Neonatal/Pediatric Medicine—A Literature Review

Rallis,

Baltogianni,

Kapetaniou

et al. 2024

JPM

View full text Add to dashboard Cite

Bioinformatics is a scientific field that uses computer technology to gather, store, analyze, and share biological data and information. DNA sequences of genes or entire genomes, protein amino acid sequences, nucleic acid, and protein–nucleic acid complex structures are examples of traditional bioinformatics data. Moreover, proteomics, the distribution of proteins in cells, interactomics, the patterns of interactions between proteins and nucleic acids, and metabolomics, the types and patterns of small-molecule transformations by the biochemical pathways in cells, are further data streams. Currently, the objectives of bioinformatics are integrative, focusing on how various data combinations might be utilized to comprehend organisms and diseases. Bioinformatic techniques have become popular as novel instruments for examining the fundamental mechanisms behind neonatal diseases. In the first few weeks of newborn life, these methods can be utilized in conjunction with clinical data to identify the most vulnerable neonates and to gain a better understanding of certain mortalities, including respiratory distress, bronchopulmonary dysplasia, sepsis, or inborn errors of metabolism. In the current study, we performed a literature review to summarize the current application of bioinformatics in neonatal medicine. Our aim was to provide evidence that could supply novel insights into the underlying mechanism of neonatal pathophysiology and could be used as an early diagnostic tool in neonatal care.

show abstract

Study on identification of a three-microRNA panel in serum for diagnosing neonatal early onset sepsis

Cited by 3 publications

References 25 publications

Role of microRNAs in Immune Regulation with Translational and Clinical Applications

Role of microRNAs in Immune Regulation with Translational and Clinical Applications

Application of Advanced Molecular Methods to Study Early-Onset Neonatal Sepsis

Bioinformatics in Neonatal/Pediatric Medicine—A Literature Review

Contact Info

Product

Resources

About