Study of the skin-penetration promoting effect and mechanism of combined system of curcumin liposomes prepared by microfluidic chip and skin penetrating peptides TD-1 for topical treatment of primary melanoma

Zhu, Yingyin; Xiao, Wuqing; Zhong, Wan-Ling; Cheng, Xi; Ye, Jinhong; Zhang, Qing; Wu, Huichao; Du, Shouying

doi:10.1016/j.ijpharm.2023.123256

Cited by 6 publications

(6 citation statements)

References 47 publications

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“…In this context, the skin tissue architecture allows for its utilization as a unique administration route for various drugs and active compounds incorporated into delivery systems, such as liposomes [54][55][56]. Liposomes typically release active compounds upon contact with skin cells; however, it is well-established that several factors influence the permeation and efficacy of liposomes in the skin.…”

Section: Skin and Topical Delivery Of Liposomesmentioning

confidence: 99%

“…Liposomes typically release active compounds upon contact with skin cells; however, it is well-established that several factors influence the permeation and efficacy of liposomes in the skin. These factors include the concentration of active compounds, physicochemical characteristics, composition, and the production method of the formulation [52,56]. Additionally, skin conditions such as integrity and hydration play a crucial role [54].…”

Section: Skin and Topical Delivery Of Liposomesmentioning

confidence: 99%

“…While liposomes have demonstrated utility in enhancing the delivery and absorption of active compounds into the skin, it is important to note that the delivery of the encapsulated molecules in these vesicles relies on the type and composition of the liposome [54,[56][57][58]. Various mechanisms have been proposed for the skin delivery of liposomes, including (i) adsorption or fusion with the SC, which is commonly observed conventional vesicles composed solely of phospholipids, and (ii) penetration through the skin pores or cutaneous appendix, which is associated more with membrane-modified liposomes such as ethosomes, transfersomes, and transethosomes, facilitating greater drug permeation through the skin [37,59,60].…”

Section: Skin and Topical Delivery Of Liposomesmentioning

confidence: 99%

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Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Miranda,

Cruz,

Girão

et al. 2024

Pharmaceutics

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Sunscreen products are essential for shielding the skin from ultraviolet (UV) radiation, a leading cause of skin cancer. While existing products serve this purpose, there is a growing need to enhance their efficacy while minimizing potential systemic absorption of UV filters and associated toxicological risks. Liposomal-based formulations have emerged as a promising approach to address these challenges and develop advanced photoprotective products. These vesicular systems offer versatility in carrying both hydrophilic and lipophilic UV filters, enabling the creation of broad-spectrum sunscreens. Moreover, their composition based on phospholipids, resembling that of the stratum corneum, facilitates adherence to the skin’s surface layers, thereby improving photoprotective efficacy. The research discussed in this review underscores the significant advantages of liposomes in photoprotection, including their ability to limit the systemic absorption of UV filters, enhance formulation stability, and augment photoprotective effects. However, despite these benefits, there remains a notable gap between the potential of liposomal systems and their utilization in sunscreen development. Consequently, this review emphasizes the importance of leveraging liposomes and related vesicular systems as innovative tools for crafting novel and more efficient photoprotective formulations.

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Section: Skin and Topical Delivery Of Liposomesmentioning

confidence: 99%

Section: Skin and Topical Delivery Of Liposomesmentioning

confidence: 99%

Section: Skin and Topical Delivery Of Liposomesmentioning

confidence: 99%

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Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Miranda,

Cruz,

Girão

et al. 2024

Pharmaceutics

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“…The mechanism of action of chemical enhancers is entirely dependent on their structural properties; effects have been described for dimethyl sulphoxide, azone, alcohols such as ethanol and propylene glycol, surfactants including phospholipids and fatty acids, such as oleic acid [ 24 ] and terpenes [ 25 ]. Cell-penetrating peptides are among the most recent approaches [ 26 ]. Vehicle strategies to promote drug penetration into the skin involve adaptation of the vehicle to increase mass flux across the SC, e.g., by supersaturation, formation of solvent-rich microemulsions or use of ionic liquids.…”

Section: Skin Penetrationmentioning

confidence: 99%

Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

Lunter,

Klang,

Eichner

et al. 2024

Pharmaceutics

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Skin is the largest organ and a multifunctional interface between the body and its environment. It acts as a barrier against cold, heat, injuries, infections, chemicals, radiations or other exogeneous factors, and it is also known as the mirror of the soul. The skin is involved in body temperature regulation by the storage of fat and water. It is an interesting tissue in regard to the local and transdermal application of active ingredients for prevention or treatment of pathological conditions. Topical and transdermal delivery is an emerging route of drug and cosmetic administration. It is beneficial for avoiding side effects and rapid metabolism. Many pharmaceutical, technological and cosmetic innovations have been described and patented recently in the field. In this review, the main features of skin morphology and physiology are presented and are being followed by the description of classical and novel nanoparticulate dermal and transdermal drug formulations. The biophysical aspects of the penetration of drugs and cosmetics into or across the dermal barrier and their investigation in diffusion chambers, skin-on-a-chip devices, high-throughput measuring systems or with advanced analytical techniques are also shown. The current knowledge about mathematical modeling of skin penetration and the future perspectives are briefly discussed in the end, all also involving nanoparticulated systems.

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“…8 Research reports that CUR plays a beneficial role in preventing, treating, and controlling cancer symptoms, such as breast cancer, colorectal cancer, prostate cancer, and melanoma. [9][10][11][12] Although CUR may enhance chemotherapy and chemotherapy prevention effects on cancer cells, it is safe and has almost no side effects even at high dose. 13 The evidence from the literature has indicated that CUR is an effective compound with antineoplastic effects.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Curcumin Application to Melanoma in Mice

Teng,

Li,

Shi

et al. 2024

Ann Plast Surg

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Objective Melanoma is a skin tumor that poses a serious threat to human health. Our study explores the effectiveness and safety of curcumin in the treatment of melanoma based on animal models, and providing evidence-based medical evidence for curcumin in the treatment of malignant melanoma. Methods The study collected all randomized controlled trial data from the establishment of the database to October 2023 of curcumin for the treatment of melanoma in mice by searching PubMed, Embase, and the Cochrane Library. According to inclusion and exclusion criteria, data were extracted and quality assessment of included studies was performed by using the SYRCLE (Systematic Review Center for Laboratory animal Experimentation) animal experiment bias risk assessment tool. RevMan 5.4 and Stata 15.1 software were used for meta-analysis. Results Eighteen randomized controlled trials were included in this study with a total of 185 mouse models, including 93 mice in the experimental group and 92 in the control group. The results of meta-analysis showed that the IC50 (inhibitory concentrations of 50%) in the experimental group is lower than that of the control group [standardized mean difference (SMD) = −4.68, 95% confidence interval (CI) (−7.30, −2.06), P < 0.01]; the tumor volume is significantly smaller than the control group [SMD = −3.10, 95% CI (−4.45, −1.75), P < 0.01]; the tumor weight is smaller than the control group [SMD = −3.01, 95% CI (−4.81, −1.21), P < 0.01]. However, there was no significant statistical difference in the apoptosis rate between the experimental group and the control group [SMD = 2.27, 95% CI (−1.39, 5.92), P < 0.01]. Conclusion Based on animal models for meta-analysis, curcumin can inhibit the growth and proliferation of melanoma in mice. Melanoma may be an effective method for treating melanoma. However, this result still requires further in-depth research.

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Study of the skin-penetration promoting effect and mechanism of combined system of curcumin liposomes prepared by microfluidic chip and skin penetrating peptides TD-1 for topical treatment of primary melanoma

Cited by 6 publications

References 47 publications

Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection

Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

The Efficacy of Curcumin Application to Melanoma in Mice

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