Study of the Relationship between Genetics and Geography in Determining the Quality of Astragali Radix

Liu, Jing; Chen, Hubiao; Guo, Baolin; Zhao, Zhongzhen; Liang, Zhitao; Yi, Tao

doi:10.1248/bpb.34.1404

Cited by 22 publications

(14 citation statements)

References 26 publications

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“…The ML tree showed that the samples from different locations were divided into different clusters. The results were consistent to a certain degree with those of previous studies[ 28 , 29 ]. According to the report by Liu et al ., the ITS sequence for A .…”

Section: Discussionsupporting

confidence: 93%

Chemical and genetic diversity of Astragalus mongholicus grown in different eco-climatic regions

Zheng

Brinckmann³

et al. 2017

PLoS ONE

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Astragalus mongholicus Bunge (Fabaceae) is an important plant source of the herbal drug known as Radix Astragali, which is used worldwide as a medicinal ingredient and a component of food supplement. Russian Federation, Mongolia, Kazakhstan, and China are the main natural distribution areas of A. mongholicus in the world. However, the quality of medicinal plant varies among different locations. As for A. mongholicus, limited literature focused on its biodiversity mechanism. Here, we combined the chemometric analysis of chemical components with genetic variation, as well as climatic and edaphic traits, to reveal the biodiversity mechanism of A. mongholicus. Results showed that the detected chemical, genetic and climatic traits comprehensively contributed to the quality diversity of A. mongholicus. The eight main chemical components, as well as the inorganic elements of P, B and Na were all significant chemical factors. The precipitation and sunshine duration were the main distinguishing climatic factors. The inorganic elements As, Mn, P, Se and Pb were the distinguishing edaphic factors. The systematic method was firstly established for this medicinal plant in order to illustrate the formation of diversity in terms of quality, and provide scientific evidence for geographic indications and climatic adaptation in production and in the clinical application of herbal medicinal plants.

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Section: Discussionsupporting

confidence: 93%

Chemical and genetic diversity of Astragalus mongholicus grown in different eco-climatic regions

Zheng

Brinckmann³

et al. 2017

PLoS ONE

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“…Recently, there are growing evidences that Astragalus extract may be a potential anti-tumorigenic agent. For instance, hepatocarcinogenesis could be prevented in rats fed with the aqueous extract of Astragalus, which is mainly composed of Astragalus polysaccharides [9]. There are also reports that describe the potentiating effect of Astragalus extract in recombinant interleukin-2-generated lymphokine-activated cells upon the anti-tumorigenic action of drugs against murine renal carcinoma [10].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells

Wang

Xing

et al. 2013

Diagn Pathol

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BackgroundAstragalus memebranaceus is a traditional Chinese herbal medicine used in treatment of common cold, diarrhea, fatigue, anorexia and cardiac diseases. Recently, there are growing evidences that Astragalus extract may be a potential anti-tumorigenic agent. Some research showed that the total saponins obtained from Astragalus membranaceus possess significant antitumorigenic activity. Gastric cancer is one of the most frequent cancers in the world, almost two-thirds of gastric cancer cases and deaths occur in less developed regions. But the effect of Astragalus membranaceus on proliferation, invasion and apoptosis of gastric cancer BGC-823 cells remains unclear.MethodsAstragalus saponins were extracted. Cells proliferation was determined by CCK-8 assay. Cell cycle and apoptosis were detected by the flow cytometry. Boyden chamber was used to evaluate the invasion and metastasis capabilities of BGC-823 cells. Tumor growth was assessed by subcutaneous inoculation of cells into BALB/c nude mice.ResultsThe results demonstrated that total Astragalus saponins could inhibit human gastric cancer cell growth both in vitro and in vivo, in additional, Astragalus saponins deceased the invasion ability and induced the apoptosis of gastric cancer BGC-823 cells.ConclusionsTotal Astragalus saponins inhibited human gastric cancer cell growth, decreased the invasion ability and induced the apoptosis. This suggested the possibility of further developing Astragalus as an alternative treatment option, or perhaps using it as adjuvant chemotherapeutic agent in gastric cancer therapy.

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“…Radix astragali is the root of the perennial herb Astragalus membranaceus (14). As a well-established traditional Chinese medicine, it has been used for the treatment of cardiovascular disease and is believed to possess immune stimulatory, antiviral and antioxidative effects.…”

Section: Introductionmentioning

confidence: 99%

Astragalus polysaccharide ameliorates H2O2-induced human umbilical vein endothelial cell injury

Han

Tang

Lü

et al. 2017

Molecular Medicine Reports

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Endothelial dysfunction caused by reactive oxygen species (ROS) has been implicated in numerous cardiovascular diseases. Astragalus polysaccharide (APS), an important bioactive component extracted from the Chinese herb Astragalus membranaceus, has been widely used for the treatment of cardiovascular disease. The present study aimed to investigate the effects of APS on hydrogen peroxide (H2O2)-induced human umbilical vein endothelial cell (HUVEC) injury. Following treatment with 400 µM H2O2 for 24 h, cell viability was decreased and apoptosis was increased. However, pretreatment with APS for 1 h significantly attenuated H2O2-induced injury in HUVECs. In addition, APS decreased intracellular ROS levels, increased the protein expression of endothelial nitric oxide synthase and copper-zinc superoxide dismutase, elevated intracellular cyclic guanosine monophosphate (an activity marker for nitric oxide) levels and restored the mitochondrial membrane potential, compared with cells treated with H2O2 only. In conclusion, the results of the present study suggested that APS may protect HUVECs from injury induced by H2O2 via increasing the cell antioxidant capacity and nitric oxide (NO) bioavailability, which may contribute to the improvement of the imbalance between ROS and NO levels.

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Study of the Relationship between Genetics and Geography in Determining the Quality of Astragali Radix

Cited by 22 publications

References 26 publications

Chemical and genetic diversity of Astragalus mongholicus grown in different eco-climatic regions

Chemical and genetic diversity of Astragalus mongholicus grown in different eco-climatic regions

RETRACTED ARTICLE: Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells

Astragalus polysaccharide ameliorates H2O2-induced human umbilical vein endothelial cell injury

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