volume 272, issue 1-2, P181-187 2004
DOI: 10.1016/j.ijpharm.2003.11.026
View full text

Abstract: The aim of the present study was to investigate the phase behavior of solid dispersions made up of PEG 6000 and itraconazole using DSC. Solid dispersions were prepared by solvent evaporation. DSC analysis of pure PEG 6000 showed three endothermic events, representing the melting transitions of the three different crystal modifications. It was shown that itraconazole decreased the formation of the polymer modifications with melting transitions at 56 and 59 degrees C but promoted the formation of the modificatio…

expand abstract