Study of the influence of bacterial melanin on brain plasticity

Gevorkyan, O. V.; Meliksetyan, I. B.; Petrosyan, Tigran; Ovsepyan, A. S.; Agadzhanyan, A. E.; Saghiyan, A. S.

doi:10.1134/s1819712408040168

Cited by 6 publications

(4 citation statements)

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“…Different concentrations of BM have been tested by us in previous series of experiments. The concentration 6mg/ml calculated as 170 mg/kg showed to be the most effective (Gevorkyan et al, 2007;Gevorkyan et al, 2008). It had more favorable and expressed effects on nervous tissue regeneration, sprouting, and functional recovery than the higher doses of BM.…”

Section: Discussionmentioning

confidence: 90%

Effects of Bacterial Melanin on Movement, Posture, and Skilled Balancing Deficits After Unilateral Destruction of Substantia Nigra Pars Compacta in Rats

Petrosyan¹,

Gevorkyan

Hovsepyan

2013

Journal of Motor Behavior

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Sixteen adult male rats were initially trained to an instrumental conditioned reflex (ICR) and subjected to unilateral destruction of substantia nigra pars compacta. Part of the animals was injected with bacterial melanin solution on the next day of destruction. The other 8 rats served as the control group. Recovery rates for ICR and dynamics of paralyzed hindlimb movements were studied in both groups. Conditioned reflex and contralateral to lesion hindlimb movements recovered faster in rats injected with bacterial melanin after the destruction.

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Section: Discussionmentioning

confidence: 90%

Effects of Bacterial Melanin on Movement, Posture, and Skilled Balancing Deficits After Unilateral Destruction of Substantia Nigra Pars Compacta in Rats

Petrosyan¹,

Gevorkyan

Hovsepyan

2013

Journal of Motor Behavior

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“…Melanin promotes chemical transport, resulting in faster nerve impulses and further acting as neuroprotection [ 25 ]. These particular features of melanin elucidate their incidence in organs, and tissues that are connected with impulse transmission systems, like body skin, nervous system, and retina [ 26 ]. Therefore, melanin metabolism abnormalities may have a role in the etiology (genesis) of illnesses such as Parkinsonism, which was shown to be associated with melanin metabolism disorders.…”

Section: Applications Of Melaninmentioning

confidence: 99%

Natural Melanin: Current Trends, and Future Approaches, with Especial Reference to Microbial Source

El‐Naggar

Saber

2022

Polymers

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Melanin is a universal natural dark polymeric pigment, arising in microorganisms, animals, and plants. There is a couple of pieces of literature on melanin, each focusing on a different issue, the goal of the present review is to focus on microbial melanin. It has numerous benefits with very few drawbacks. The current situation and expected trends are discussed. Intriguing, numerous studies have provoked a serious necessity for a comprehensive assessment of microbial melanin pigments. So that, such review would help scholars from diverse backgrounds to realize the importance of melanin pigments isolated from microorganisms, with this aim in mind, information, and hypothesis from this review could be the paradigm for studies on melanin in the next era.

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“…Bacterial melanin (BM) has proved to be a potent stimulator of axonal growth (Petrosyan et al 2012;Petrosyan and Gevorkyan 2013). In a previous series of experiments, BM was used to facilitate recovery processes in rats after unilateral ablation of the sensorimotor cortex that had caused paresis of limbs (Gevorkyan et al 2007(Gevorkyan et al , 2008. BM supports axonal regeneration, stimulates sprouting of nerve fibers and vascularization.…”

Section: Introductionmentioning

confidence: 99%

Initial training facilitates posttraumatic motor recovery in rats after pyramidal tract lesion and in conditions of induced regeneration

Petrosyan

2014

Somatosensory & Motor Research

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Training induces plastic changes within the normal and injured brain. Experiments were performed on 48 albino rats. Part of the experimental animals were initially trained to a balancing instrumental conditioned reflex (ICR). Unilateral bulbar pyramidotomy performed in all rats caused contralateral hemiparesis. To make the study results more reliable, recovery of motor skills was evaluated also in conditions of stimulated regeneration. The obtained results indicate that preoperative training in rats contributes to the accelerated recovery of learned motor skills.

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Study of the influence of bacterial melanin on brain plasticity

Cited by 6 publications

References 0 publications

Effects of Bacterial Melanin on Movement, Posture, and Skilled Balancing Deficits After Unilateral Destruction of Substantia Nigra Pars Compacta in Rats

Effects of Bacterial Melanin on Movement, Posture, and Skilled Balancing Deficits After Unilateral Destruction of Substantia Nigra Pars Compacta in Rats

Natural Melanin: Current Trends, and Future Approaches, with Especial Reference to Microbial Source

Initial training facilitates posttraumatic motor recovery in rats after pyramidal tract lesion and in conditions of induced regeneration

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