Study of the influence of age and weaning on the contractile and metabolic characteristics of bovine muscle

Picard, Brigitte; Gagnière, Hélène; Geay, Y.; Hocquette, J. F.; Robelin, J.

doi:10.1051/rnd:19950105

Cited by 27 publications

(16 citation statements)

References 22 publications

(27 reference statements)

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“…Connected to nutrition, mild dietary restriction on beef cattle has little apparent effect on muscle characteristics or meat quality (Casser-Malek et al, 2004). However, dietary changes during weaning in calves appear to have an appreciable effect on increasing the number of oxidative fibres (Picard et al, 1995). Under moderate protein and energy dietary restriction (20% less protein and 7% less energy) in young growing pigs, we recently found, with the use of a porcine cDNA muscle micro-array, significant increase in the accumulation of intramuscular fat, which could have production implications on meat quality .…”

Section: Fibre Number: Mediators Of Muscle Hyperplasiamentioning

confidence: 89%

Key signalling factors and pathways in the molecular determination of skeletal muscle phenotype

Chang

2007

Animal

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The molecular basis and control of the biochemical and biophysical properties of skeletal muscle, regarded as muscle phenotype, are examined in terms of fibre number, fibre size and fibre types. A host of external factors or stimuli, such as ligand binding and contractile activity, are transduced in muscle into signalling pathways that lead to protein modifications and changes in gene expression which ultimately result in the establishment of the specified phenotype. In skeletal muscle, the key signalling cascades include the Ras-extracellular signal regulated kinase-mitogen activated protein kinase (Erk-MAPK), the phosphatidylinositol 3 0 -kinase (PI3K)-Akt1, p38 MAPK, and calcineurin pathways. The molecular effects of external factors on these pathways revealed complex interactions and functional overlap. A major challenge in the manipulation of muscle of farm animals lies in the identification of regulatory and target genes that could effect defined and desirable changes in muscle quality and quantity. To this end, recent advances in functional genomics that involve the use of micro-array technology and proteomics are increasingly breaking new ground in furthering our understanding of the molecular determinants of muscle phenotype.

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Section: Fibre Number: Mediators Of Muscle Hyperplasiamentioning

confidence: 89%

Key signalling factors and pathways in the molecular determination of skeletal muscle phenotype

Chang

2007

Animal

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“…Picard et al, 1995 and2002) and adipose tissues (e.g. reviews from Boone et al, 2000;Hausman et al, 2009) in different species, the precise pattern of IMF ontogenesis and its regulation remains still poorly characterized.…”

Section: How Might Marbling Begin?mentioning

confidence: 99%

Intramuscular fat content in meat-producing animals: development, genetic and nutritional control, and identification of putative markers

Hocquette

Gondret

Baéza³

et al. 2010

Animal

637

447

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Intramuscular fat (IMF) content plays a key role in various quality traits of meat. IMF content varies between species, between breeds and between muscle types in the same breed. Other factors are involved in the variation of IMF content in animals, including gender, age and feeding. Variability in IMF content is mainly linked to the number and size of intramuscular adipocytes. The accretion rate of IMF depends on the muscle growth rate. For instance, animals having a high muscularity with a high glycolytic activity display a reduced development of IMF. This suggests that muscle cells and adipocytes interplay during growth. In addition, early events that influence adipogenesis inside the muscle (i.e proliferation and differentiation of adipose cells, the connective structure embedding adipocytes) might be involved in interindividual differences in IMF content. Increasing muscularity will also dilute the final fat content of muscle. At the metabolic level, IMF content results from the balance between uptake, synthesis and degradation of triacylglycerols, which involve many metabolic pathways in both adipocytes and myofibres. Various experiments revealed an association between IMF level and the muscle content in adipocyte-type fatty acid-binding protein, the activities of oxidative enzymes, or the delta-6-desaturase level; however, other studies failed to confirm such relationships. This might be due to the importance of fatty acid fluxes that is likely to be responsible for variability in IMF content during the postnatal period rather than the control of one single pathway. This is evident in the muscle of most fish species in which triacylglycerol synthesis is almost zero. Genetic approaches for increasing IMF have been focused on live animal ultrasound to derive estimated breeding values. More recently, efforts have concentrated on discovering DNA markers that change the distribution of fat in the body (i.e. towards IMF at the expense of the carcass fatness). Thanks to the exhaustive nature of genomics (transcriptomics and proteomics), our knowledge on fat accumulation in muscles is now being underpinned. Metabolic specificities of intramuscular adipocytes have also been demonstrated, as compared to other depots. Nutritional manipulation of IMF independently from body fat depots has proved to be more difficult to achieve than genetic strategies to have lipid deposition dependent of adipose tissue location. In addition, the biological mechanisms that explain the variability of IMF content differ between genetic and nutritional factors. The nutritional regulation of IMF also differs between ruminants, monogastrics and fish due to their digestive and nutritional particularities.

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“…Muscle biopsy samples of the Semitendinosus muscle were taken on all animals on d 111 as previously described [11]. They were immediately frozen in liquid N 2 and stored at -80 o C, awaiting the determination of total muscle protein [12] and DNA [13] contents as well as the activities of oxidative metabolism enzymes (citrate synthase (CS) [14]; and cytochrome-coxydase (COX) [15] and glycolytic metabolism enzymes (phosphofructokinase (PFK) [16]; and lactate dehydrogenase (LDH) [17].…”

Section: Measurementsmentioning

confidence: 99%

The incorporation of solubilized wheat proteins in milk replacers for veal calves: effects on growth performance and muscle oxidative capacity

et al. 2003

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-Replacement of skim milk proteins by solubilized wheat protein (SWP) in milk replacers for veal calves would contribute to the reduction in feeding costs. The occurrence of metabolic disorders has, however, been reported. Forty-two male calves received one of three treatments over 140 days: a control diet, a diet containing SWP without or with branched-chain amino acid supplementation. Liveweight gain, carcass yield, color and conformation did not show any significant differences. No metabolic disorders were noted. Supplementation with branched-chain amino acids reduced the marginal Val deficiency but did not modify the growth performances. With the SWP containing diets, the plasma metabolite profile was characteristic of those observed with non-clotting diets. It was statistically correlated to the changes in the orientation of the Semitendinosus muscle energy metabolism towards a more oxidative type and to indications of a lower efficiency of amino acid utilisation for protein deposition. At the present levels of inclusion, SWP proved to be an interesting alternative to the sole use of whey as the protein source in milk replacers for veal calves.veal / preruminant calf / wheat proteins / milk replacer / growth / blood parameters Reprod. Nutr. Dev. 43 (2003) 57-76 57

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Study of the influence of age and weaning on the contractile and metabolic characteristics of bovine muscle

Cited by 27 publications

References 22 publications

Key signalling factors and pathways in the molecular determination of skeletal muscle phenotype

Key signalling factors and pathways in the molecular determination of skeletal muscle phenotype

Intramuscular fat content in meat-producing animals: development, genetic and nutritional control, and identification of putative markers

The incorporation of solubilized wheat proteins in milk replacers for veal calves: effects on growth performance and muscle oxidative capacity

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