Study of the enhancing effect of sodium chloride injection on radiofrequency ablation of hepatocellular carcinoma

Kady, Nabeel El; Hasan, Eman Medhat; Esmat, Gamal; Nabeel, Mohamad; Hamdy, Sherif; Fouad, Ahmad; Omran, Dalia; Darweesh, Samar K; Khattab, H. M.

doi:10.1016/j.ajg.2009.05.005

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…Ascites was not clinically detected in any of our patients. This is in agreement with El‐Kady et al . and Mohey et al ., who reported that none of their patients had ascites.…”

Section: Discussionsupporting

confidence: 93%

“…22 Ascites was not clinically detected in any of our patients. This is in agreement with El-Kady et al 23 and Mohey et al, 22 who reported that none of their patients had ascites. Additionally, most patients were at Child-Pugh A classification (73.1%), which is similar to that reported previously 20,24 where the Child-Pugh A score were 93.33% and 85%, respectively.…”

Section: Discussionsupporting

confidence: 92%

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Value of microwave ablation in treatment of large lesions of hepatocellular carcinoma

Medhat

Aziz

Nabeel

et al. 2015

J of Digest Diseases

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“…Ascites was not clinically detected in any of our patients. This is in agreement with El‐Kady et al . and Mohey et al ., who reported that none of their patients had ascites.…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Value of microwave ablation in treatment of large lesions of hepatocellular carcinoma

Medhat

Aziz

Nabeel

et al. 2015

J of Digest Diseases

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“…This may be due to the large size of the right lobe of the liver which is 6 times the left lobe [ 25 ]. Also, Haseeb [ 26 ] and ElKady et al [ 27 ] found in their study that 75-100% of focal lesions were found in the right lobe.…”

Section: Discussionmentioning

confidence: 95%

Clinical Significance of Plasma Osteopontin Level as a Biomarker of Hepatocellular Carcinoma

Salem

Atti

Raziky

et al. 2013

Gastroenterology Research

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BackgroundBiomarkers of hepatocellular carcinoma (HCC) are helpful in screening, diagnosis and follow up of cases. Osteopontin (OPN) is a glycoprotein secreted by osteoblasts, osteoclasts, macrophages and T cells, and is over-expressed in a variety of tumors, including carcinomas of liver, stomach, breast, lung, colon, and prostate. So, the aim of this study was to verify the possibility of using the plasma Osteopontin level as a biomarker for diagnosis of HCC.MethodsThe study included 70 subjects divided into three groups: group I had 30 patients with HCC (proved by histopathology or combined spiral CT and elevated alpha-fetoprotein) on top of HCV, group II had 30 patients with HCV infection and group III had 10 healthy subjects serving as control. Osteopontin level was measured in plasma of the studied subjects by ELISA, serum alpha fetoprotein (AFP) level was also measured by EIA.ResultsOsteopontin levels were significantly elevated in patients with HCC and in HCV patients in comparison to control group (P: 0.005). There was significant correlation between OPN and AFP levels (P: 0.00). The sensitivity and specificity of OPN for selective detection of HCC group over the non-HCC group (HCV group and healthy control group) were73% and 54%, respectively, at a cut-off value of 128.5 ng/mL. Plasma OPN levels directly correlated with the tumor number but not with the size of the tumor (P: 0.00).ConclusionPlasma OPN level appears to be an additional biomarker for HCC detection.

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“…All the Egyptian studies had close mean ages, as the study done by Salama et al [12] that included 158 patients with ages ranged from 35 to 69 years, Nabeel [13] had 58 patients with HCC with a mean age of 50.5 + 6.9 years, ElKady et al [7] their mean age was 51 to 57 +9 years and El-Kady et al [8] their mean age was 50.60±3 to 53.80±7.37 years. Also Omata et al [14] study had a mean age of 56.3 years.…”

Section: Discussionmentioning

confidence: 99%

“…The study sample size was relatively small as we were studying different percutaneous ablation therapies for HCC like PELIT, combined RFA with (alcohol, acetic acid, saline [7] hypertonic saline &TACE [8]) and microwave ablation [9]. So, this affected the size of each study.…”

Section: Statistical Analysesmentioning

confidence: 99%

Percutaneous Ethanol Lipiodol Injection Therapy versus Radiofrequency Ablation in Treatment of Hepatocellular Carcinoma

Darweesh¹

2016

GHOA

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Background & aim: Percutaneous ethanol injection (PEI) has become one of the most widely used procedures for treatment of hepatocellular carcinoma (HCC) up to 5 cm. PEI is occasionally ineffective due to in homogenous distribution within tumor while percutaneous ethanol lipiodol injection therapy (PELIT) is useful irrespective of vasculature, as HCC cells are characterized by selective, active uptake of lipiodol. The primary outcome was the higher success rate of PELIT with fewer sessions in comparison to RFA in HCC. Patients and methods:A prospective study was conducted on 43 patients with HCC, 27 of them under went PELIT & 16 underwent RFA. Both groups had biopsy after one week and lesions with partial necrosis underwent additional PELIT or RFA respectively. Triphasic MRI and CT were performed one month after the end of sessions of PELIT and RFA respectively.Results: Tru-cut biopsy revealed complete necrosis in 17 (81%) patients of PELIT and 11(68.7%) patients of RFA group. Six patients of PELIT group were not biopsied due to non-visible lesions by ultrasound, ascites or low PC. After additional sessions (in partial necrosis), triphasic MRI for PELIT group showed non-enhancement in 26(92.3%) patients and triphasic CT for RFA group showed non-enhancement in 15 (93.6%) patients and one patient in each group showed peripheral enhancement. Conclusion:PELIT is safe & effective for treatment of HCC, the number of sessions are equal to the diameter of HCC in cm (fewer sessions than RFA or PEI alone). PELIT can be performed for cases liable or contraindicated to RFA. Triphasic MRI is the standard for follow up of cases of PELIT.

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Study of the enhancing effect of sodium chloride injection on radiofrequency ablation of hepatocellular carcinoma

Cited by 6 publications

References 10 publications

Value of microwave ablation in treatment of large lesions of hepatocellular carcinoma

Value of microwave ablation in treatment of large lesions of hepatocellular carcinoma

Clinical Significance of Plasma Osteopontin Level as a Biomarker of Hepatocellular Carcinoma

Percutaneous Ethanol Lipiodol Injection Therapy versus Radiofrequency Ablation in Treatment of Hepatocellular Carcinoma

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