Study of structural and magnetic properties and heat induction of gadolinium-substituted manganese zinc ferrite nanoparticles for in vitro magnetic fluid hyperthermia

Jadhav, Swati V.; Shewale, P.S.; Shin, Byoungchul; Patil, Maheshkumar Prakash; Kim, G.D.; Rokade, Ashish A.; Park, S.S.; Bohara, Raghvendra A.; Yang, Yu

doi:10.1016/j.jcis.2019.01.063

Cited by 44 publications

(16 citation statements)

References 64 publications

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“…This is a prerequisite for hyperthermia, particularly when healthy cells surrounding a solid tumour are damaged when temperature reaches > 48 °C. 29,116,117 Fig. 6b compiled results from the evaluation of the hyperthermic efficacy of the (γ-Fe 2 O 3 /PLGA)/CS NPs against T-84 cells.…”

Section: In Vitro Magnetic Fluid Hyperthermiamentioning

confidence: 99%

Engineering of stealth (maghemite/PLGA)/chitosan (core/shell)/shell nanocomposites with potential applications for combined MRI and hyperthermia against cancer

et al. 2021

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Section: In Vitro Magnetic Fluid Hyperthermiamentioning

confidence: 99%

Engineering of stealth (maghemite/PLGA)/chitosan (core/shell)/shell nanocomposites with potential applications for combined MRI and hyperthermia against cancer

et al. 2021

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“…[6] Magnetic nanoparticles (MNPs) can alter longitudinal (T 1 ) and transverse (T 2 ) relaxation times and resulted in changes in MR signal intensity. [78]…”

Section: Introductionmentioning

confidence: 99%

“…Comparison of various ferrite NPs has shown that manganese ferrite and especially zinc-substituted manganese ferrite NPs are great candidates for MRI contrast agents due to higher magnetic susceptibility and magnetic saturation than magnetite and other ferrite NPs. [79] According to the literature, application of manganese-zinc ferrite MNPs (MZF NPs) as potential magnetic carriers was conducted by many researchers. [678910] MZF NPs hydrothermally have been synthesized by Zahraei et al .…”

Section: Introductionmentioning

confidence: 99%

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Assessment of manganese-zinc ferrite nanoparticles as a novel magnetic resonance imaging contrast agent for the detection of 4T1 breast cancer cells

et al. 2019

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Background:The aim of the study was to evaluate the potential of manganese-zinc ferrite nanoparticles (MZF NPs) as a novel negative magnetic resonance imaging (MRI) contrast agents for 4T1 (mouse mammary carcinoma) and L929 (murine fibroblast) cell lines.Methods:MZF NPs and its suitable coating, polyethylene glycol (PEG) via covalent bonding, were investigated under in vitro condition. The cytotoxicity of MZF NPs was tested by 3-(4,5-dimethyl thiazolyl-2)-2,5-diphenyltetrazolium bromide assay after 12 and 24 h of incubation. To evaluate the potential of MZF NPs as T2 MRI nanocontrast agent, images were obtained from phantom containing different Fe concentrations and T2 relaxivity (r2) was measured. The viability of both 4T1 breast cancer and L929 murine fibroblast cell lines incubated with different Fe concentrations.Results:In vitro T2-weighted MRI showed that signal intensity of 4T1 cells was lower than that of L929 as control cells. T2-weighted MRI showed that signal intensity of MZF NPs enhanced with increasing concentration of NPs. The values of 1/T2 relaxivity (r2) for coated MZF NPs with PEG found to be 85.5 mM−1 s−1 which is higher than that of commercially clinical used (Sinerem) MRI contrast agent.Conclusion:The results showed that MZF NPs have potential to detect breast cancer cells (4T1) and also have high contrast resolution between normal (L929) and cancerous cells (4T1) which is a suitable nanoprobe for T2-weighted MR imaging contrast agents.

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“…However, these NPs possessed improved magnetic properties and heating performances. The NPs resulted to be non-toxic for human lung carcinoma cells alone, but highly cytotoxic in synergy with the MF stimulation, electing such doped NPs as promising anticancer agent for magnetic hyperthermia [ 68 ].…”

Section: Radiofrequency Responding Npsmentioning

confidence: 99%

Remotely Activated Nanoparticles for Anticancer Therapy

Racca

Cauda

2020

Nano-Micro Lett.

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Cancer has nowadays become one of the leading causes of death worldwide. Conventional anticancer approaches are associated with different limitations. Therefore, innovative methodologies are being investigated, and several researchers propose the use of remotely activated nanoparticles to trigger cancer cell death. The idea is to conjugate two different components, i.e., an external physical input and nanoparticles. Both are given in a harmless dose that once combined together act synergistically to therapeutically treat the cell or tissue of interest, thus also limiting the negative outcomes for the surrounding tissues. Tuning both the properties of the nanomaterial and the involved triggering stimulus, it is possible furthermore to achieve not only a therapeutic effect, but also a powerful platform for imaging at the same time, obtaining a nano-theranostic application. In the present review, we highlight the role of nanoparticles as therapeutic or theranostic tools, thus excluding the cases where a molecular drug is activated. We thus present many examples where the highly cytotoxic power only derives from the active interaction between different physical inputs and nanoparticles. We perform a special focus on mechanical waves responding nanoparticles, in which remotely activated nanoparticles directly become therapeutic agents without the need of the administration of chemotherapeutics or sonosensitizing drugs.

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Study of structural and magnetic properties and heat induction of gadolinium-substituted manganese zinc ferrite nanoparticles for in vitro magnetic fluid hyperthermia

Cited by 44 publications

References 64 publications

Engineering of stealth (maghemite/PLGA)/chitosan (core/shell)/shell nanocomposites with potential applications for combined MRI and hyperthermia against cancer

Engineering of stealth (maghemite/PLGA)/chitosan (core/shell)/shell nanocomposites with potential applications for combined MRI and hyperthermia against cancer

Assessment of manganese-zinc ferrite nanoparticles as a novel magnetic resonance imaging contrast agent for the detection of 4T1 breast cancer cells

Remotely Activated Nanoparticles for Anticancer Therapy

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