Study of Serum Phosphate levels and its clinical significance in Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar State

Impact of Hypophosphatemia and Hypomagnesaemia on Diabetic Ketoacidosis patient's Outcome in Medical Intensive Care Unit

“…Finally, out of the 68 patients, 59 (86.8%) patients were discharged, while 9 patients died (13.2%). These results were in agreement with Betdur, et al [8] who showed a mortality rate of 12%. While Agarwal, et al [6] had a higher mortality rate (30.0%) that was referred to limited resources in the face of large patient admissions in tertiary care hospitals plus delayed referrals.…”

“…There is evidence that the early onset of DM affects Po4 metabolism leading to high energy Po4 depletion and tissue hypoxia [10] . At 2 days after admission, our study founded that 50(73.5%), 9 (13.2%) and 9 (13.2%) patients showed normal, mild, and moderate hypophosphatemia respectively, while Betdur, et al [8] founded that 31 (62%), 13 (26%), 6 (12%) patients showed normal, mild and moderate hypophosphatemia respectively at 1 day of admission. On the day of discharge, Po4 level was normal in 56 (94.9%) patients out of 59 living patients, after exclusion of the nine dead ones, two (3.8%) patients showed mild hypophosphatemia, and one (1.6%) patient showed moderate hypophosphatemia.…”

“…On the day of discharge, Po4 level was normal in 56 (94.9%) patients out of 59 living patients, after exclusion of the nine dead ones, two (3.8%) patients showed mild hypophosphatemia, and one (1.6%) patient showed moderate hypophosphatemia. While Betdur, et al [8] study founded that 42 (84%), 5 (10%), and 3 (6%) patients showed normal, mild, and moderate hypophosphatemia, respectively. The nine dead patients showed a mild hypophosphatemia in one patient (11%) and moderate hypophosphatemia in eight patients (89%) at the last reading before death (between 6-10 days of ICU stay).…”

“…In our study, Po4 level at admission was normal in 56 (82.4%), mild hypophosphatemia was reported in 7 (10.2%), moderate hypophosphatemia in 4 (5.8%), while severe hypophosphatemia was reported in only one patient and he was admitted by fits followed by paresis with a dramatic response after correction of phosphate level. Betdur, et al [8] reported that 34 (68%) patients had normal phosphate levels, 11(22%) showed mild hypophosphatemia, 4(8%) showed moderate and 1(2%) showed severe hypophosphatemia. Po4 is essential for cellular ATP production.…”