Study of respiratory disorders in endoscopically negative and positive gastroesophageal reflux disease

Maher, Maha M; Darwish, Atef M.

doi:10.4103/1319-3767.61233

Cited by 18 publications

(21 citation statements)

References 32 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, according to previous studies that have shown an impairment of gas exchange and/or impairment in spirometric functions [22,23], our study for the first time revealed significant differences in QS/QT values between both groups. In that context, our results suggest extension of pulmonary dead space as the potential new additional mechanism responsible for lung function damage in GERD patients.…”

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

Gastroesophageal reflux disease and pulmonary function: A potential role of the dead space extension

et al. 2012

View full text Add to dashboard Cite

SummaryBackgroundTo evaluate the differences in the existence and size of dead space in patients with and without Gastroesophageal Reflux Disease (GERD and non-GERD) expressed through the size of intrapulmonary shunt (QS/QT).Material/MethodsThe study enrolled 86 subjects – 43 patients referred for endoscopy because of symptoms of GERD (heartburn, acid regurgitation, dysfagia) and 43 healthy subjects with similar anthropometric characteristics without GERD symptoms. Based on endoscopy findings, patients were classified into the erosive reflux disease (ERD) group and non-erosive reflux disease (NERD) group. Spirometry values, single-breath diffusing capacity of the lung for carbon monoxide (DLCO) and intrapulmonary shunt (venous shunt – QS/QT) determined by the oxygen method were measured in all participants.ResultsStatistically significant differences between GERD and non-GERD groups in FVC (p=0.034), FEV1 (p=0.002), FEV1/FVC (p=0.001), and PEF (p=0.001) were observed. There were no statistically significant differences in FEF 25% (p=0.859), FEF 50% (p=0.850), and FEF 75% (p=0.058). Values of DLCO (p=0.006) and DLCO/VA (p=0.001) were significantly lower and QS/QT was significantly higher (p=0.001) in the GERD group than in the non-GERD group. However, in both groups the average values of DLCO and DLCO/VA expressed as a percentage of predictive values were within normal range, while the value of QS/QT in the GERD group showed pathological (6.0%) mean value (normal value ≤5.0%). There were no significant differences in respiratory function test results between patients with ERD and NERD.ConclusionsOur results suggest that microaspiration of stomach contents may cause surfactant damage, development of microatelectasis, and dead space expansion with consequent increase of intrapulmonary (venous) shunt.

show abstract

Section: Discussionsupporting

confidence: 69%

“…Previously studies have revealed statistically significant differences in respiratory symptoms and functional tests in GERD patients, with a positive correlation with degree of gastroesophageal reflux severity [22,23]. Maher and Darwish reported serious loss of respiratory function in ERD compared with NERD patients [24].…”

Section: Discussionmentioning

confidence: 99%

Gastroesophageal reflux disease and pulmonary function: A potential role of the dead space extension

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In contrast with the findings of our study, another study in Egyptian patients found that pulmonary manifestations were significantly higher in ERD patients than in NERD patients. 19 Although we report an association between high risk of OSA and NERD, we did not identify any obvious explanation for the mechanism of this association. We hypothesize that NERD patients may be at risk of extraesophageal symptoms.…”

Section: Discussioncontrasting

confidence: 56%

Association Between Non-erosive Reflux Disease and High Risk of Obstructive Sleep Apnea in Korean Population

You¹,

Oh²,

Seo³

et al. 2014

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsObstructive sleep apnea is becoming more important in gastroesophageal reflux disease (GERD) patients. This study investigated the prevalence of high risk for obstructive sleep apnea in GERD patients in comparison with that in healthy controls using the Berlin Questionnaire. We also investigated the risk factors for obstructive sleep apnea in GERD patients. MethodsWe enrolled 1,007 subjects: 776 healthy controls, 115 individuals with erosive reflux disease, and 116 with non-erosive reflux disease. GERD was diagnosed and classified using endoscopy and a reflux questionnaire. The Berlin Questionnaire was used to evaluate obstructive sleep apnea. ResultsMore patients in the GERD group (28.2%) had higher risk for obstructive sleep apnea than healthy controls (20.4%, P = 0.036). More patients with non-erosive disease (32.8%) had higher risk for obstructive sleep apnea (OSA) than patients with erosive disease (20.9%) and controls (20.4%, P = 0.010). On multivariate analysis, non-erosive disease was a high risk factor for obstructive sleep apnea (odds ratio [OR], 1.82; P = 0.011). Age ≥ 55 years (OR, 1.83; P < 0.001) and a high body mass index (≥ 25 kg/m 2 ) (OR, 2.76; P < 0.001) were also identified as risk factors. Nocturnal GERD was related to high risk for OSA in non-erosive disease patients (OR, 2.97; P = 0.019), but not in erosive disease patients. ConclusionsHigh risk for OSA is more prevalent in GERD patients than in controls. Non-erosive reflux disease, age ≥ 55, and a high BMI are associated with high risk for OSA.

show abstract

“…Out of this large pool, only 50 studies met our inclusion criteria with a focus on patients with reflux symptoms and provided sufficient information about sex distribution (Table 4). Twenty-five of the reports originated in Asia [37,, nine in Europe [99][100][101][102][103][104][105][106], seven in the US [56,[107][108][109][110][111][112], two in South America [113][114][115][116], four in African countries [117,118], and one in Canada [15], the studies reported data on 121 267 patients with 50.0 ± 1.2% women (range: 14.7-76.1%; P = 0.45). Considering the more recent emphasis of symptoms rather than endoscopic findings in the definition of GER, we examined time trends by separating studies into 3-year blocks, on the basis of their year of publication.…”

Section: Sex and Endoscopic Findings: Patient Studiesmentioning

confidence: 99%

Reflux and sex

Nusrat

Bielefeldt

2012

European Journal of Gastroenterology & Hepatology

View full text Add to dashboard Cite

Gastroesophageal reflux (GER) affects ∼10-20% of American adults. Although symptoms are equally common in men and women, we hypothesized that sex influences diagnostic and therapeutic approaches in patients with GER. PubMed database between 1997 and October 2011 was searched for English language studies describing symptoms, consultative visits, endoscopic findings, use and results of ambulatory pH study, and surgical therapy for GER. Using data from Nationwide Inpatient Sample, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality, we determined the sex distribution for admissions and reflux surgery between 1997 and 2008. Studies on symptoms or consultative visits did not show sex-specific differences. Even though women are less likely to have esophagitis or Barrett's esophagus, endoscopic studies enrolled as many women as men, and women were more likely to undergo ambulatory pH studies with a female predominance in studies from the US. Surgical GER treatment is more commonly performed in men. However, studies from the US showed an equal sex distribution, with Nationwide Inpatient Sample data demonstrating an increase in women who accounted for 63% of the annual fundoplications in 2008. Despite less common or severe mucosal disease, women are more likely to undergo invasive diagnostic testing. In the US, women are also more likely to undergo antireflux surgery. These results suggest that healthcare-seeking behavior and socioeconomic factors rather than the biology of disease influence the clinical approaches to reflux disease.

show abstract

Study of respiratory disorders in endoscopically negative and positive gastroesophageal reflux disease

Cited by 18 publications

References 32 publications

Gastroesophageal reflux disease and pulmonary function: A potential role of the dead space extension

Gastroesophageal reflux disease and pulmonary function: A potential role of the dead space extension

Association Between Non-erosive Reflux Disease and High Risk of Obstructive Sleep Apnea in Korean Population

Reflux and sex

Contact Info

Product

Resources

About