Study of Prevalence and Antimicrobial Susceptibility Pattern of Enterococci Isolated from Clinically Relevant Samples with Special Reference to High Level Aminoglycoside Resistance (HLAR) in a Rural Tertiary Care Hospital

Rana, Deeksha; Sande, Suvarna

doi:10.14260/jemds/2020/537

Cited by 6 publications

(13 citation statements)

References 22 publications

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“…In our study, the high frequency of the MDR phenotype (76%) was detected in the strains isolated from clinical samples. This frequency was consistent with the reports published by Jia et al [11], and Rana and Sande [34] in China and India, but fewer than those reported by Nasaj et al [36], and Said et al [30] in Iran and Egypt. Several studies have shown various multidrug efflux pumps in E. faecium, such as efmA, emeA, and efrAB, which are involved in resistance to fluoroquinolones.…”

Section: Discussionsupporting

confidence: 92%

“…Differences in antibiotic resistance in our region and other countries may be related to the regional variation in antibiotic practice patterns. The frequency of resistance to vancomycin was 77.3%, which is comparable to the rate reported in previous studies from Iran [28,33], and India [34], but higher than those reported by Jia et al [11], Boccella et al [29], and Karna et al [26]. Different rates of antibiotic resistance in different countries can be due to the geographical distribution of resistance, differences in antibiotic use patterns, and environmental factors.…”

Section: Discussionsupporting

confidence: 73%

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Antibiotic resistance assessment and multi-drug efflux pumps of Enterococcus faecium isolated from clinical specimens

Mirzaii

Alebouyeh

Sohrabi

et al. 2023

J Infect Dev Ctries

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Introduction: Enterococcus faecium is a major cause of community and hospital-acquired infections. Due to limited options for infection with fluoroquinolones-resistant Enterococci, novel therapeutics are urgently needed. Efflux pumps are contributed to fluoroquinolones resistance phenotype in this bacterium and novel inhibitors that target these efflux pumps could be effective in patients. In this research, the possible synergistic effect of an efflux pump inhibitor (EPI), thioridazine, with ciprofloxacin was investigated against clinical isolates of E. faecium. Methodology: A total of 88 isolates of E. faecium from clinical specimens were studied from August 2017 to September 2018. Conventional phenotypic and molecular methods characterized all the isolates. Standard susceptibility tests and molecular assays determined the antibiotic resistance profiles and the frequency of efflux pump genes. Minimum inhibitory concentrations (MICs) to ciprofloxacin (CIP) in the presence and absence of thioridazine were measured by the micro-broth dilution method. Results: The highest antibiotic resistance rate among E. faecium isolates was related to ciprofloxacin (96.8%), levofloxacin (94.3%), and imipenem (90.9%), respectively. The highest frequency of efflux pump determinants was related to efmA (60, 68%), followed by emeA (48, 54.5%), and efrA and/or efrB genes (45, 51%). The efflux pump inhibitor showed ≥ 2-fold decrease in the MIC value of ciprofloxacin in 48.2% of the isolates. Conclusions: Efflux pump inhibitor genes efrAB, efmA, and emeA are common among the E. faecium clinical isolates. Our results supported the administration of thioridazine, as an efflux pump inhibitor, in fluoroquinolone-resistant E. faecium infections due to its synergistic effect with CIP.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 73%

Antibiotic resistance assessment and multi-drug efflux pumps of Enterococcus faecium isolated from clinical specimens

Mirzaii

Alebouyeh

Sohrabi

et al. 2023

J Infect Dev Ctries

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“…A study conducted in India by Manoj K. Gupta, Chirag Vohra, Pankaja Raghav (Assessment of knowledge, attitudes, and practices about antibiotic resistance among medical students in India) the most important factor contributing to antimicrobial resistance in India is selfprescription and by conducting this study they came with result that 45% medical students accepted that they buy antimicrobial without a medical prescription and the knowledge of medical students was quite satisfactory on antimicrobial use and antimicrobial resistance [14]. Related studies were also reported by Rana et al [15] Dangre et al [16] Ingle et al [17] and Bhute et al [18] Mallick et. al.…”

Section: Discussionsupporting

confidence: 56%

A Study Design for Awareness Regarding Appropriate Antimicrobial use and Antimicrobial Resistance among Health Care Professionals and Lay Persons

Turankar

Gaidhane

Choudhari

et al. 2021

JPRI

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Aim: This study is designed to determine the awareness of anti-microbial resistance and appropriate antimicrobials use among health care professionals (intern, junior residents and nurses) and lay persons. Methods: The study will be held at rural tertiary care hospital in central India including junior resident, Interns and nurses, patient and their relatives. Survey tool and data questionnaire will be provided to participants in English and Marathi. Results: Comparison of knowledge of antimicrobial resistance among hospital staff, patient and their relatives will be done. Conclusion: There is a need to frame policies to prevent excessive use of Antimicrobials and to increase awareness about the knowledge of proper usage antimicrobial and antimicrobial resistance among lay person.

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“…There is a close evolutionary and ecological relationship that binds antimicrobial biosynthesis and resistance closely. Here, we analyze the genetic and physiological methods that are developed for understanding antimicrobial biosynthesis to test the resistance level of microorganisms and emphasize the present examples of their uses [16][17][18]…”

Section: Discussionmentioning

confidence: 99%

Anti-Microbial Resistance: A Major Global Issue

Kewalramani

Chandi

2021

JPRI

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Antimicrobial Resistance (AMR) happens when infinitesimal life forms, diseases, developments, and parasites change as time goes on and now do not respond to drugs making them harder to treat and extending the risk of affliction spread, outrageous infirmity, and demise. Because of medical checks, counter-agent poisons and other antimicrobial medications become ineffective and defilements become logically problematic or hard to treat. AMR happens ordinarily after some time, regularly through innate changes. Antimicrobial safe natural elements are found in people, animals, food, plants, and the environment (in water, soil, and air). They can spread starting with one individual then onto the next or among people and animals, including from the food of animal start. The essential drivers of antimicrobial block fuse the maltreatment and maltreatment of antimicrobials; nonattendance of induction to clean water, sanitization and tidiness (WASH) for the two individuals and animals; powerless defilement and affliction expectation and control in clinical benefits workplaces and farms; defenseless permission to quality, sensible medications, vaccinations and diagnostics; nonappearance of care and data; and nonattendance of approval of sanctioning. Excessive enemy of disease use has become one of the top allies of the headway of hostile to contamination resistance. Against microbial stewardship programs appear to be useful in reducing speeds of serum poison obstacles. The Netherlands has a minimum speed of against contamination suggested in the Organisation for Economic co-operation and Development (OECD), at a speed of 11.4 portrayed step by step measurements Defined Daily Dose (DDD) per 1,000 people every day in 2011. Germany and Sweden also have lower supporting rates, with Sweden's rate had been declining beginning around 2007. Greece, France, and Belgium have high suggesting speeds of more than 28 DDD.

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Study of Prevalence and Antimicrobial Susceptibility Pattern of Enterococci Isolated from Clinically Relevant Samples with Special Reference to High Level Aminoglycoside Resistance (HLAR) in a Rural Tertiary Care Hospital

Cited by 6 publications

References 22 publications

Antibiotic resistance assessment and multi-drug efflux pumps of Enterococcus faecium isolated from clinical specimens

Antibiotic resistance assessment and multi-drug efflux pumps of Enterococcus faecium isolated from clinical specimens

A Study Design for Awareness Regarding Appropriate Antimicrobial use and Antimicrobial Resistance among Health Care Professionals and Lay Persons

Anti-Microbial Resistance: A Major Global Issue

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