Study of Postpartum Alopecia

Schiff, Bencel L.

doi:10.1001/archderm.1963.01590170067011

Cited by 27 publications

(8 citation statements)

References 6 publications

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“…Increased hair shedding (or telogen effluvium) is thought to occur due to post-partum hormonal changes (Lynfield 1960;Schiff and Kern 1963;Gizlenti and Ekmekci 2013) or stress (Kligman 1961). Our findings that Prl promotes HF quiescence by directly regulating bulge SC activity support a previously hypothesized role for Prl during post-partum hair shedding (Randall 2007).…”

Section: Prl and Hair Cycling In Humanssupporting

confidence: 80%

Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

et al. 2014

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In most tissues, the prevailing view is that stem cell (SC) niches are generated by signals from within the nearby tissue environment. Here, we define genetic changes altered in hair follicle (HF) SCs in mice treated with a potent SC activator, cyclosporine A (CSA), which inhibits the phosphatase calcineurin (CN) and the activity of the transcription factor nuclear factor of activated T cells c1 (Nfatc1). We show that CN/Nfatc1 regulates expression of prolactin receptor (Prlr) and that canonical activation of Prlr and its downstream signaling via Jak/Stat5 drives quiescence of HF SCs during pregnancy and lactation, when serum prolactin (Prl) levels are highly elevated. Using Prl injections and genetic/pharmacological loss-of-function experiments in mice, we show that Prl signaling stalls follicular SC activation through its activity in the skin epithelium. Our findings define a unique CN-Nfatc1-PrlrStat5 molecular circuitry that promotes persistent SC quiescence in the skin.

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Section: Prl and Hair Cycling In Humanssupporting

confidence: 80%

Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

et al. 2014

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“…Telogen effluvium has been reported to occur in approximately 20% of postpartum women . Hair regrowth usually occurs with in four to six months, but can take longer . As with humans, hair loss also occurs in rhesus macaques ( Macaca mulatta ) around the time of parturition, but pregnant females also tend to have worse coats than non‐pregnant females .…”

Section: Introductionmentioning

confidence: 99%

Alopecia in rhesus macaques (Macaca mulatta): Association with pregnancy and chronic stress

Lutz

Menard

Rosenberg

et al. 2019

J of Medical Primatology

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Background Alopecia in captive non‐human primates is often presented as a welfare issue. However, it is a complex condition with a number of possible causes. The purpose of this study was to assess the impact of pregnancy and hair cortisol concentrations on alopecia in rhesus macaques. Methods Subjects were 113 socially housed adult female rhesus macaques (27 pregnant, 35 nursing infants, 51 controls). During routine physicals, photographs were taken for alopecia assessment and hair samples were collected for cortisol assay. Results Alopecia was more prevalent in pregnant than in control females, but there was no association between alopecia and hair cortisol. However, there was a significant effect of pregnancy on hair cortisol. Nursing females had higher hair cortisol levels than pregnant females, which had higher levels than control females. Conclusions Although alopecia does not appear to be associated with hair cortisol, both alopecia and hair cortisol were associated with pregnancy.

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“…Pregnancy increases the percentage of hairs in the growing (anagen) phase of the follicular cycle. Several months after the pregnancy has ended hair may fall when the excess number of anagen hairs turn into resting (telogen) hairs (Pecoraro, Barman & Astore, 1969;Schiff, Pawtucket & Kern, 1963). Because oral contraceptives induce a state of pseudo-pregnancy, it has been suggested that hair loss occurring when medication is stopped may be analogous to post-partum hair loss.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Hair Loss and Oral Contraceptives

Griffiths

1973

Obstetrical & Gynecological Survey

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Diffuse loss of scalp hair occurs in some women when they stop taking mixed oestrogen/progestogen oral contraceptives. Nine women had diffuse alopecia while still continuing to take the pill. The relationship between the hair thinning and oral contraceptives is discussed.Do oral contraceptives cause diffuse loss of scalp hair in women ? The association has been reported (Cormia, 1967; Greenwald, 1976;Dugois et al, 1971), and discussed {British Medical Journal, 1968;Jelinek, 1970). This study examines the relationship further. METHODThe series comprises thirty-one women seen consecutively for diffuse thinning of scalp hair between March 1970 and March 1971. Post-menopausal or pre-pubertal patients have been excluded. All patients were examined personally.Details of the distribution of the hair loss, the length, colour, calibre and lustre of the hair, state of the body hair, and changes in the nails were recorded.The investigation of all patients included: haemoglobin and film; serum iron and total iron-binding capacity; Wassermann reaction; protein-bound iodine; tri-iodothyronine resin uptake and total thyroxine, if a patient was taking oral contraceptives.A biopsy of the scalp was examined in six patients.To find the prevalence of the use of oral contraceptives, women attending the dermatology clinics whose symptoms did not include hair loss were asked whether they had taken an oral contraceptive in the previous 12 months. RESULTS At the time of the study 30% of the 203 women between the menarche and the menopause who attended the dermatology clinic were taking an oral contraceptive, or had taken one in the previous 12 months.The relationship between diffuse alopecia and taking oral contraceptives is shown numerically in Table i. There is no statistically significant correlation between the two factors.Requests for reprints: St John's Hospital for Diseases of the Skin,

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Study of Postpartum Alopecia

Cited by 27 publications

References 6 publications

Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

Calcineurin/Nfatc1 signaling links skin stem cell quiescence to hormonal signaling during pregnancy and lactation

Alopecia in rhesus macaques (Macaca mulatta): Association with pregnancy and chronic stress

Diffuse Hair Loss and Oral Contraceptives

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