Study of MICA alleles in 201 African Americans by multiplexed single nucleotide extension (MSNE) typing

Zhang, Yanzheng; Han, Mei; Vorhaben, Robert; Giang, C.; Lavingia, Bhavna; Šťastný, Peter

doi:10.1016/s0198-8859(02)00743-7

Cited by 36 publications

(29 citation statements)

References 25 publications

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“…MICA*008 appears to be stably expressed on the surface of cells; our results show that it is functionally active in enhancing killing by the NKL cell line, and it is known to be the most frequent allele in many populations (16,37). The results of our NK cytotoxicity experiments support the idea that this allele, which resists down-regulation, is functionally relevant and may aid in the elimination of virus-infected cells.…”

Section: Discussionsupporting

confidence: 74%

Effect of Human Cytomegalovirus on Expression of MHC Class I-Related Chains A

Zou

Bresnahan

Taylor

et al. 2005

The Journal of Immunology

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The MHC-encoded MHC class I-related chains A (MICA) glycoproteins are known to enhance the functions of NK and T cells by ligating the stimulating receptor NKG2D and appear to play an important role in host defense. Human CMV (HCMV) evades the immune response in many different ways, but has not previously been found to down-regulate MICA. We have found that a common form of MICA, which has a nucleotide insertion in exon 5 corresponding to the transmembrane region and no cytoplasmic tail, was increased on the surface of fibroblasts HFS-13 compared with the mock-infected sample of the same cells that had been cultured to confluence. However, an astrocytoma cell line, U373, which has a full-length variant of MICA, showed that the expression of MICA was decreased after HCMV infection. Retroviral transduction of different MICA alleles into fibroblasts HFF-D, which express no MICA of their own, established that full-length MICA was down-regulated by HCMV, and the truncated form was not. Fibroblasts with decreased MICA due to HCMV infection were found to be protected from NK cell killing, whereas in the presence of the truncated form of MICA, the virus-infected cells were destroyed. Thus, the truncated form of MICA, which is the most common, has a mutation that allows it to persist on the surface and hinder efforts of the virus to evade the immune response.

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Section: Discussionsupporting

confidence: 74%

Effect of Human Cytomegalovirus on Expression of MHC Class I-Related Chains A

Zou

Bresnahan

Taylor

et al. 2005

The Journal of Immunology

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“…A wide allelic distribution including 16 different MICA alleles was observed, among which MICA *010, MICA*002:01, MICA*008:01, and MICA*019 were predominant. Comparison of the allelic frequencies for MICA between our cohort and other populations, including Asians, Africans, and Caucasians [10,[13][14][15][16][17][18][19][20][21], indicated different distributions (Table 2). Whereas MICA*019 was observed as a high-frequency allele (14.93%), this allele was detected in only 1 to 3% of individuals from other populations.…”

Section: Discussionmentioning

confidence: 97%

Distribution of MICA haplotypes in a Chinese Han population

Xu¹,

Xia²,

Tian³

et al. 2012

Human Immunology

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“…MICA 00801 and *004 are among the most common alleles in African Americans; a lower frequency of MICA 002 was found in ME compared with African Americans (af ϭ 0.073 vs. 0.279), whereas *004 allele frequencies were higher (af ϭ 0.232) compared with U.S. whites (af ϭ 0.060) and similar to nonwhite (af ϭ 0.200) and African American (af ϭ 0.187) individuals [20,21].…”

Section: Allele Frequenciesmentioning

confidence: 92%