Study of Magnesium, Copper, Zinc, Iron and Ceruloplasmin in Liver Cirrhosis and Ovarian Cancer Ascitic Patients

Pasha, M; Qamar, Ali; Narasu, M. Laxmi; Rao, K. Panduranga; Prabhakar, B.; Suseela, Kundoly Velayudhan; Balakrishna, N.; Srinivasulu, M.; Reddy, M. Gopal

doi:10.9734/bjmmr/2014/6774

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…In order to further confirm the superiority of our method, this sensor was used to determine Cu 2+ in complexed biology samples. As is known to all, the concentration of Cu 2+ is significantly increased in ascite fluid caused by ovarian cancer, which can even be 10-fold higher when compared to that of the normal . Similarly, it is reported that the concentration of Cu 2+ in urine of a cirrhotic patient will be remarkably increased .…”

Section: Resultsmentioning

confidence: 69%

“…As is known to all, the concentration of Cu 2+ is significantly increased in ascite fluid caused by ovarian cancer, which can even be 10-fold higher when compared to that of the normal. 65 Similarly, it is reported that the concentration of Cu 2+ in urine of a cirrhotic patient will be remarkably increased. 66 Measuring Cu 2+ in urine can be used to directly warn the patient of the liver disease and monitor health of the liver after the operation.…”

Section: ■ Results and Discussionmentioning

confidence: 89%

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Ratiometric Detection of Cu²⁺ Using a Luminol-Tb-GMP Nanoprobe with High Sensitivity and Selectivity

Tong

et al. 2018

ACS Sustainable Chem. Eng.

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A novel ratiometric fluorescent method for the detection of copper ions (Cu2+) based on the stimulus-responsive dual-ligand lanthanide luminol-Tb-GMP coordination polymer nanoparticle (CPNP) fluorescent probe is reported in this study. The luminol-Tb-GMP CPNPs are composed of Tb3+ as the center metal ions and ligand of GMP together with the cofactor luminol ligands as the bridging ligands. In the presence of Cu2+, the fluorescence of GMP-Tb as the response moiety is dynamically quenched, while the fluorescence of luminol used as the reference remains constant. Hence, ratiometric fluorescent monitoring of Cu2+ can be achieved by measuring the ratio of the fluorescence at the 430 nm (F430) wavelength of luminol to the 547 nm (F547) wavelength of Tb3+ in the fluorescent spectra of the luminol-Tb-GMP CPNPs suspension. In this sensing approach, when Cu2+ coordinates with a luminol/GMP unit, the fluorescence of the Tb3+ units located in the vicinity Cu2+ will also be quenched. Thus, the sensing sensitivity is highly improved due to the large number of luminol/GMP units in CPNPs. The obtained Cu2+ detection limit is as low as 4.2 nM (S/N = 3), which is approximately 3 orders of magnitude lower than that for the single ligand GMP-Tb CPNPs (3.5 μM) without luminol doping. The linear range is from 0.01 to 80 μM. Because luminol is directly linked to the CPNP molecule, which serves as a strong chelating reagent for Cu2+, the common disturbances of Hg2+ and Ag+ are almost completely eliminated, highly improving the selectivity for practical application with little interference. The present method has been successfully applied in the detection of Cu2+ in river water, ascites, and urine samples, indicating that luminol-Tb-GMP CPNPs can be used to detect Cu2+ in environmental water and complexed biological samples.

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Section: Resultsmentioning

confidence: 69%

Section: ■ Results and Discussionmentioning

confidence: 89%

Ratiometric Detection of Cu²⁺ Using a Luminol-Tb-GMP Nanoprobe with High Sensitivity and Selectivity

Tong

et al. 2018

ACS Sustainable Chem. Eng.

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“…These results are in line with previous data that suggest T1-relaxation rates (1/T1) of ascites are linearly proportional to protein content in non-malignant cases 7 . In contrast to non-malignant ascites, where paramagnetic ions are only marginally present 15 , higher concentrations of iron can be found in malignant ascites due to secondary iron overload. As the paramagnetic contribution of iron increases relaxation 7 , this phenomenon is expected to increase the ability to separate malignant and non-malignant ascites by means of T1-mapping.…”

Section: Discussionmentioning

confidence: 76%

Evaluation of malignant effusions using MR-based T1 mapping

Kuetting

Luetkens

Faron

et al. 2021

Sci Rep

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Our aim was to investigate the diagnostic yield of rapid T1-mapping for the differentiation of malignant and non-malignant effusions in an ex-vivo set up. T1-mapping was performed with a fast modified Look-Locker inversion-recovery (MOLLI) acquisition and a combined turbo spin-echo and inversion-recovery sequence (TMIX) as reference. A total of 13 titrated albumin-solutions as well as 48 samples (29 ascites/pleural effusions from patients with malignancy; 19 from patients without malignancy) were examined. Samples were classified as malignant-positive histology, malignant-negative histology and non-malignant negative histology. In phantom analysis both mapping techniques correlated with albumin-content (MOLLI: r = − 0.97, TMIX: r = − 0.98). MOLLI T1 relaxation times were shorter in malignancy-positive histology fluids (2237 ± 137 ms) than in malignancy-negative histology fluids (2423 ± 357 ms) as well as than in non-malignant-negative histology fluids (2651 ± 139 ms); post hoc test for all intergroup comparisons: < 0.05. ROC analysis for differentiation between malignant and non-malignant effusions (malignant positive histology vs. all other) showed an (AUC) of 0.89 (95% CI 0.77–0.96). T1 mapping allows for non-invasive differentiation of malignant and non-malignant effusions in an ex-vivo set up.

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“…These studies are of Pasha et al. () for brain cancer, Taysi et al. () for laryngeal cancer, Ozyilkan et al.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies on systemic malignancies have also demonstrated increased levels of ceruloplasmin in cases of cancer as compared to that of the healthy controls. These studies are ofPasha et al (2014) for brain cancer,Taysi et al (2003) for laryngeal cancer,Ozyilkan et al (1991) for breast cancer,Nayak et al (2003) for colon and prostate cancer,Doustjalali et al (2006) for nasopharyngeal cancer, and Jeong et al (2008) for uterine cervix cancer. The increase in ceruloplasmin levels in premalignancies and in various malignancies is an indicator of body's antioxidant defense mechanism.…”

mentioning

confidence: 99%

Determination of role of ceruloplasmin in oral potentially malignant disorders and oral malignancy—A cross‐sectional study

Shah

Venkatesh

2017

Oral Diseases

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Study of Magnesium, Copper, Zinc, Iron and Ceruloplasmin in Liver Cirrhosis and Ovarian Cancer Ascitic Patients

Cited by 5 publications

References 16 publications

Ratiometric Detection of Cu²⁺ Using a Luminol-Tb-GMP Nanoprobe with High Sensitivity and Selectivity

Ratiometric Detection of Cu²⁺ Using a Luminol-Tb-GMP Nanoprobe with High Sensitivity and Selectivity

Evaluation of malignant effusions using MR-based T1 mapping

Determination of role of ceruloplasmin in oral potentially malignant disorders and oral malignancy—A cross‐sectional study

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Study of Magnesium, Copper, Zinc, Iron and Ceruloplasmin in Liver Cirrhosis and Ovarian Cancer Ascitic Patients

Cited by 5 publications

References 16 publications

Ratiometric Detection of Cu2+ Using a Luminol-Tb-GMP Nanoprobe with High Sensitivity and Selectivity

Ratiometric Detection of Cu2+ Using a Luminol-Tb-GMP Nanoprobe with High Sensitivity and Selectivity

Evaluation of malignant effusions using MR-based T1 mapping

Determination of role of ceruloplasmin in oral potentially malignant disorders and oral malignancy—A cross‐sectional study

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Ratiometric Detection of Cu²⁺ Using a Luminol-Tb-GMP Nanoprobe with High Sensitivity and Selectivity

Ratiometric Detection of Cu²⁺ Using a Luminol-Tb-GMP Nanoprobe with High Sensitivity and Selectivity