Study of<i>Helicobacter pylori</i>genotype status in saliva, dental plaques, stool and gastric biopsy samples

Momtaz, Hassan; Souod, Negar; Dabiri, Hossein; Sarshar, Meysam

doi:10.3748/wjg.v18.i17.2105

Cited by 88 publications

(79 citation statements)

References 30 publications

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“…Several investigators have detected H. pylori in dental plaque and saliva, and also showed that periodontal pockets ! 5 mm in depth are associated with increased odds of H. pylori seropositivity (43)(44)(45)(46). Therefore, long-term H. pylori infection is considered to cause not only gastric mucosal atrophy, but also periodontitis.…”

Section: Discussionmentioning

confidence: 99%

A Study on the Relationship between Reflux Esophagitis and Periodontitis

et al. 2016

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Objective Metabolic syndrome and dental erosion have been demonstrated to correlate with gastroesophageal acid reflux disease (GERD), while periodontitis has been reported to have a positive relationship with metabolic syndrome. However, no correlation between periodontitis and GERD has yet been reported. We therefore investigated the relationship between periodontitis and GERD. Methods The subjects consisted of 280 individuals who visited the Health Center for a detailed medical checkup examination. Each underwent upper endoscopy and periodontitis examinations, with the latter performed by measuring the concentrations of lactate dehydrogenase and hemoglobin in saliva. The subjects were divided into those with positive and negative periodontitis findings, and the prevalence rates of endoscopically proven reflux esophagitis, dyslipidemia, hypertension, and hyperglycemia were compared. Results The number of subjects positive for periodontitis was 93, while 187 had negative findings. The prevalence of reflux esophagitis was not different between the positive and negative groups (8.6% vs. 8.0%). In addition, a multiple logistic regression analysis did not identify a positive relationship between the presence of periodontitis and reflux esophagitis. On the other hand, dyslipidemia and hypertension were more frequently observed in the subjects that were positive for periodontitis. Conclusion We did not find an association between periodontitis and reflux esophagitis in the present study. On the other hand, the presence of periodontitis was found to correlate with hypertension and dyslipidemia.

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Section: Discussionmentioning

confidence: 99%

A Study on the Relationship between Reflux Esophagitis and Periodontitis

et al. 2016

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“…Helicobacter pylori is a gram-negative, spiral shaped, motile and microaerophilic bacillus with a length of 3.5μ and a width of0.5μ, which is associated with peptic/grastic ulcers (1). Although bacterial infection is asymptomatic in most cases, symptoms are found in some people and in few cases it leads to malignancies including adenocarcinoma and gastric lymphoma and other peptic disorders (2,3).…”

Section: Introductionmentioning

confidence: 99%

Correlation of 16s rRNA with serum levels of the cytokines, TNF-α and IL-1β, in subjects with a positive Helicobacter pylori Stool Antigen test (HPSA)

Moradipour

Khosravi

Mehrabi

et al. 2016

JBRMS

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Introduction:Helicobacter pylori (H. pylori), is a bacterium responsible for upper gastrointestinal tract diseases. The 16s rRNA is a common H. pylori gene which are usually preferred for diagnosis purpose. The aim of this study was to determine the prevalence and abundance of 16s rRNA in fecal samples and also evaluate correlation between the level of 16s rRNA and activities of the cytokines, TNF-α and IL-1β, in serum. Materials and methods:The present study was performed on 84 subjects with digestion problems. Fecal and blood samples were collected and 16s rRNA gene was assayed using PCR. The serum levels of TNF-α and IL-1β levels were measured by enzyme-linked immunosorbent assay (ELISA). Results:The results of the study revealed that there was a positive correlation between the 16s rRNA gene, H. pylori stool antigen (HPSA) and TNF-α cytokine. The study also noted that with every unit of increase in either of the quantified parameters of HPSA and IL-1β, the presence of 16s rRNA in fecal samples, showed a 2.98 and 1.01 times rise, respectively. Conclusion: According to the obtained results, it may be concluded that activities of cytokine TNF-a correlated well with the presence of HPSA and 16srRNA gene in the stomach's lining. Increase in the activities of HPSA and TNF-a cytokine could be associated with the presence of 16s rRNA in feces.

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“…The most commonly known virulence markers among H. pylori strains of different clinical samples of animals and human beings are the vacuolating cytotoxin (vacA) [7][8][9]. The vacA gene is associated with injury to epithelial cells of gastric tract.…”

Section: Introductionmentioning

confidence: 99%