Study of Epstein–Barr virus serological profile in Egyptian patients with Hashimoto’s thyroiditis: A case-control study

Assaad, Samir Naeim; Meheissen, Marwa Ahmed; Tayae, Eman; Alnakhal, Saher N.; Salem, Tarek M.

doi:10.1016/j.jcte.2020.100222

Cited by 8 publications

(8 citation statements)

References 23 publications

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“…Moreover, it was found that the highest percentage of patients with anti-TPO antibodies in the hypothyroidism group was 71.40%, which may indicate a higher risk of HT. These results are consistent with the study in Egypt revealed the presence of anti-TPO antibodies in HT patients, where it was 95% (Assaad et al, 2020).…”

Section: A Distribution Of Patients According To the Type Of Thyroid ...supporting

confidence: 93%

Investigation of Parvovirus B19 in Hashimoto thyroiditis

Hlail¹,

Mohammed²

2022

jsci

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Thyroiditis is a broad term that refers to a variety of clinical conditions marked by inflammation and damage to thyroid cells. These disorders could be caused by due to factors, including radiation, a microbial infection, or be linked to autoimmune thyroid disease, such as in Hashimoto thyroiditis (HT). This cross-sectional study aimed to the detection of anti-TPO antibodies and to investigate (Parvovirus B19) IgM and IgG antibodies in serum of patients to investigate their role in the pathogenesis of thyroiditis. The study included 91 patients suffering from thyroid dysfunction and diagnosed by performing of the thyroid hormone tests (FT3, FT4 and TSH) by Snibe Maglumi-800 Chemiluminescence Immunoassay, where they were divided into three groups namely (subclinical thyroiditis, hypothyroidism and hyperthyroidism). Then Moreover, the study investigates the determination which of them has HT by the detection of thyroid autoantibodies anti-TPO Ab and the detection of antibodies to specific (Parvovirus B19) IgM and IgG in the sera of patients by ELISA. The results of serology showed that the percentage of anti-TPO antibodies in the three investigated groups was (54.94%), and the highest percentage was in the hypothyroidism group, which amounted to (71.40%). The serological diagnosis also showed that the presence of antibodies to (Parvovirus B19) IgM was (90.10%) while, IgG levels were (100%) respectively. Conclusions: Parvovirus B19 infection is commonly seen in patients with thyroiditis.

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Section: A Distribution Of Patients According To the Type Of Thyroid ...supporting

confidence: 93%

Investigation of Parvovirus B19 in Hashimoto thyroiditis

Hlail¹,

Mohammed²

2022

jsci

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“…The incidence of autoimmune thyroiditis (AIT) has dramatically increased over time worldwide ( 2 ). AIT affects up to 10% of the world population and is more prevalent in women than men ( 3 ). This disease is described by lymphocytic infiltrate of the thyroid gland, with T-helper lymphocytes of the Th1 type, cytotoxic T-lymphocytes (CTL), natural killer cells (NK), monocytes, plasma cells, and lymphoid centers ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…It is the most common cause of hypothyroidism, especially in developed countries ( 5 ). HT almost begins between the third to fifth decades of life and, nearly 5% of the individuals would be affected in their life ( 3 ). The pathogenesis of HT is associated with both cellular and humoral immune responses ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of HT is associated with both cellular and humoral immune responses ( 4 ). Although HT has been controversial until now, several studies have shown that both genetic and environmental factors play a role in the etiology of the disease ( 3 ). Viral infections have been suggested as potential causes of this disease ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the association between human herpes virus 6 (HHV-6) and Hashimoto's thyroiditis

Molla¹,

Kalbasi²,

Kalantari³

et al. 2022

IJM

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Background and Objectives: Hashimoto's thyroiditis is a chronic inflammation and an autoimmune disease of the thyroid gland that causes hypothyroidism. Genetic, internal, and environmental factors are the causes of this disease. Because human herpes viruses such as herpesvirus type 6 (HHV-6) are involved in some autoimmune disorders, they may also play a role in causing this disease. This study aimed to evaluate the association between human herpes virus 6 (HHV-6) with Hashimoto's thyroiditis. Materials and Methods: In the present study, 64 samples of thyroid paraffin tissue including 32 samples of thyroid paraffin tissue of healthy individuals as control, and 32 samples of thyroid paraffin tissue of Hashimoto's thyroiditis patients were taken from the pathology department of Loghman Hakim Hospital in Tehran. A questionnaire collected demographic infor- mation of patients. After DNA extraction from the samples, the nested-PCR technique was performed using specific primers for HHV-6. Results: Totally, the HHV6-DNA was found in 34.4% of thyroid tissues of healthy individuals (81.8% female and 18.2% male) and 46.9% of patients with Hashimoto's thyroiditis (73.3% female and 26.7% male). It was found that this difference in virus frequency between the two groups was not statistically significant (P value=0.309). There was also no statistically significant relationship between the prevalence of human herpesvirus type 6 and age or sex. Conclusion: Based on the present study, the number of HHV-6-infected individuals in Hashimoto's patients and controls did not differ significantly; therefore, HHV-6 appears not to be associated with Hashimoto's thyroiditis.

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“…lymphoma, Hodgkin lymphoma, chronic lymphocytic leukemia, inflammatory bowel disease, multiple sclerosis, and IgA nephropathy. [5][6][7][8][9][10][11][12][13][14][15] However, due to the diverse immune responses to EBV, clinical manifestations of infection are often negative or atypical, posing significant challenges for diagnosis and treatment. 16 Therefore, Early and effective identification of risk factors for EBV infection in children is crucial for the prevention and treatment of suspected EBV infections.…”

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confidence: 99%

Epidemiological characteristics of Epstein‐Barr virus infection in children and distribution of disease spectrum in hospitalized patients in shandong province

Wu,

Wang,

Zeng

et al. 2024

Journal of Medical Virology

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This study aims to investigate the epidemiological characteristics of Epstein‐Barr virus (EBV) infection in children and the distribution of disease spectrum in hospitalized patients in Shandong Province. A retrospective analysis was conducted on the clinical data of children with EBV infection admitted to hospitals in Shandong Province from January 2022 to December 2022. The epidemiological characteristics, including age, gender, and clinical manifestations, were analyzed. The detection rate of EBV antibodies and the seropositivity rates of different antibodies were also examined. A total of 7124 children with EBV infection were included in this study, with an average age of 7.5 years. The male‐to‐female ratio was 1.43:1. Among the patients, the positive detection rate of EBV antibodies was 78.40%. The seropositivity rate of Epstein‐Barr viral capsid antigen‐Immunoglobin G antibodies was 57.09%. The highest incidence of EBV infection was observed in the age group 36−72 months. The urban positive rate was higher than that in rural areas. EBV infection in children in Shandong Province exhibits specific epidemiological characteristics, with a higher incidence in the age group of 36−72 months. Fever, sore throat, and fatigue are the main clinical manifestations. The detection rate of EBV antibodies is relatively high among hospitalized patients. These findings provide valuable information for controlling the transmission of children with suspected Epstein‐Barr virus infection.

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Study of Epstein–Barr virus serological profile in Egyptian patients with Hashimoto’s thyroiditis: A case-control study

Cited by 8 publications

References 23 publications

Investigation of Parvovirus B19 in Hashimoto thyroiditis

Investigation of Parvovirus B19 in Hashimoto thyroiditis

Evaluation of the association between human herpes virus 6 (HHV-6) and Hashimoto's thyroiditis

Epidemiological characteristics of Epstein‐Barr virus infection in children and distribution of disease spectrum in hospitalized patients in shandong province

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