Study of cutaneous leishmaniasis in the State of Campeche (Yucatan Peninsula), Mexico, over a period of two year

Hernández-Rivera, Mirsha Pamela; Hernandez-Montes, Omar; Chiñas-Pérez, Adelaido; Batiza-Avelar, Juan Miguel; Sánchez-Tejeda, Gustavo; Wong-Ramírez, Carlos; Monroy-Ostria, Amalia

doi:10.21149/spm.v57i1.7403

Cited by 22 publications

(26 citation statements)

References 20 publications

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“…The most affected community of this area was La Mancolona, with a 6.5% of prevalence; this village is located 3-4 km away from the crops and is more urbanized due to deforestation (Figure 3a). The most affected population in this village were adult males (66%) [19].…”

Section: Discussionmentioning

confidence: 95%

“…Dos Lagunas Sur was the most affected community, located close to the border with Belize, with 12% prevalence (Figure 2c). People in this village farm chili crops around their houses, which are located very close to the forest, and the population affected were children (50%), women, and men (50%) (Figures 2a-c and 3a-c) [19]. In relation to the vectors, L. mexicana infections in two sand fly species, Lu.…”

Section: Discussionmentioning

confidence: 99%

“…Biopsies, clinical samples, and isolates from LCL patients from several districts of Campeche state, mainly from Calakmul, were PCR amplified with specific primers for kDNA of L. braziliensis and L. mexicana complex members and primers specific for Mexican strains of L. mexicana [19] and also were analyzed by ITS1 PCR-RFLP [12]. We detected in Northern Calakmul 43% of cases infected with L. mexicana, 25% of cases with L. braziliensis complex members, 62% of mixed infection of Mx L. mexicana + L. (L.) mexicana, and 25% of cases infected with L. braziliensis complex + L. (L.) mexicana.…”

Section: Discussionmentioning

confidence: 99%

“…La Guadalupe village had the highest prevalence rate (2.2%) and children were the most affected (67%) [19].…”

Section: Discussionmentioning

confidence: 99%

“…Glucantime is marketed in 5 mL ampules containing 1.5 g of N-methyl-glucamine antimoniate, which corresponds to 425 mg of Sb51. Treatment consisted in one ampule by intramuscular injection per day until healing [19]. Table 2.…”

Section: Administration Of Meglumine Antimoniate (Glucantime ® )mentioning

confidence: 99%

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Survey of Cutaneous Leishmaniasis in Mexico: Leishmania Species, Clinical Expressions and Risk Factors

Monroy-Ostria¹,

Sánchez-Tejeda²

2017

The Epidemiology and Ecology of Leishmaniasis

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Leishmaniasis is caused by Leishmania sp., which is transmitted to human beings and reservoirs by phlebotomine sand flies, with worldwide prevalence of approximately 12 million cases with population at risk of approximately 350 million. Cutaneous leishmaniasis (CL) is the most widespread form, causing localized skin lesions (LCL), mucocutaneous leishmaniasis (MCL), or nodular lesions in diffused cutaneous leishmaniasis (DCL). American CL includes LCL and DCL caused by Leishmania mexicana complex and MCL caused by the Leishmania braziliensis complex. In Mexico, CL is distributed in three endemic areas, Gulf of Mexico, Pacific of Mexico, and Central Mexico. In order to monitor clinical outcome and adequately target treatment as well as epidemiologic studies, diagnostic kinetoplast DNA (kDNA), polymerase chain reaction (PCR), Southern and dot blotting, and ITS1 PCR-RFLP of Leishmania DNA were evaluated in samples and Leishmania isolates from patients with cutaneous ulcers from several endemic areas. In Mexico, LCL can be caused by the L. mexicana, L. braziliensis, or both complexes. DCL is caused by L.( L.) mexicana or Leishmania (L.) amazonensis and visceral leishmaniasis (VL) by Leishmania (L.) chagasi and L.( L.) mexicana in immunocompromised patients. The geographic range in which CL is endemic has increased due to urbanization, new settlements, and ecological, social, and educative conditions, which favors its permanence and transmission.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…La Guadalupe village had the highest prevalence rate (2.2%) and children were the most affected (67%) [19].…”

Section: Discussionmentioning

confidence: 99%

Section: Administration Of Meglumine Antimoniate (Glucantime ® )mentioning

confidence: 99%

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Survey of Cutaneous Leishmaniasis in Mexico: Leishmania Species, Clinical Expressions and Risk Factors

Monroy-Ostria¹,

Sánchez-Tejeda²

2017

The Epidemiology and Ecology of Leishmaniasis

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Isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives induce regulated necrosis-like cell death on Leishmania (Leishmania) mexicana

et al. 2017

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Leishmaniasis is a neglected tropical disease caused by the parasite of the genus Leishmania. About 13 million people are infected worldwide, and it is estimated that 350 million are at risk of infection. Clinical manifestations depend on the parasite species and factors related to the host such as the immune system, nutrition, housing, and financial resources. Available treatments have severe side effects; therefore, research currently focuses on finding more active and less toxic compounds. Quinoxalines have been described as promising alternatives. In this context, 17 isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives were evaluated as potential leishmanicidal agents. Their effect on the cell metabolism of Leishmania mexicana promastigotes and their cytotoxic effects on the J774.A1 cell line and on erythrocytes were evaluated, and their selectivity index was calculated. Compounds T-069 (IC = 1.49 μg/mL), T-070 (IC = 1.71 μg/mL), T-072 (IC = 6.62 μg/mL), T-073 (IC = 1.25 μg/mL), T-085 (IC = 0.74 μg/mL), and T-116 (IC = 0.88 μg/mL) were the most active against L. mexicana promastigotes and their mechanism of action was characterized by flow cytometry and microscopy. Compound T-073, the most selective quinoxaline derivative, induced cell membrane damage, phosphatidylserine exposition, reactive oxygen species production, disruption of the mitochondrion membrane potential, and DNA fragmentation, all in a dose-dependent manner, indicating the induction of regulated necrosis. Light and transmission electron microscopy showed the drastic morphological changes induced and the mitochondrion as the most sensitive organelle in response to T-073. This study describes the mechanism by which active isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide quinoxalines affect the parasite.

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Phlebotomine sand flies in rural Mayan communities of Southern Mexico: The heterogeneity of the ruralscape increases the entomological risk

Montes de Oca-Aguilar,

Euan-Canul,

Sosa-Bibiano

et al. 2024

Acta Tropica

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Study of cutaneous leishmaniasis in the State of Campeche (Yucatan Peninsula), Mexico, over a period of two year

Cited by 22 publications

References 20 publications

Survey of Cutaneous Leishmaniasis in Mexico: Leishmania Species, Clinical Expressions and Risk Factors

Survey of Cutaneous Leishmaniasis in Mexico: Leishmania Species, Clinical Expressions and Risk Factors

Isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives induce regulated necrosis-like cell death on Leishmania (Leishmania) mexicana

Phlebotomine sand flies in rural Mayan communities of Southern Mexico: The heterogeneity of the ruralscape increases the entomological risk

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