Study of correlation between epicardial fat thickness and severity of coronary artery disease

Shambu, Sunil Kumar; Desai, Nagaraj; Sundaresh, Nikhil; Babu, M Suresh; Madhu, B; Gona, Oliver Joel

doi:10.1016/j.ihj.2020.07.014

Cited by 9 publications

(7 citation statements)

References 14 publications

(16 reference statements)

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“…Also, the EAT mean thickness was found to be statistically significantly higher among those with significant coronary stenosis than those without [7.859 ± 0.691 mm versus 5.600 ± 0.386 mm] (P value < 0.001). This observation is supported by the study of Shambu et al who measured EAT in 503 patients undergoing coronary angiogram and found that mean EAT was significantly higher in the CAD group than the control group (5.55 ± 1.21 mm vs 3.25 ± 1.15 mm, p < 0.0001) [14].…”

Section: Relation Between Eat and Cardiovascular Risksupporting

confidence: 59%

“…This result was supported by Eroglu et al in 2009 who reported that the best cutoff value of EAT for CAD was 5.2 mm [5]. Also, Shambu et al found that EAT at a cutoff ≥ 4.75 mm had 87% sensitivity and 63% specificity for the prediction of significant CAD [14].…”

Section: Relation Between Eat and Cardiovascular Riskmentioning

confidence: 60%

“…Visceral fat perhaps more than total fat is implicated in atherosclerosis. Epicardial adipose tissue (EAT), a nontraditional visceral fat depot modulates coronary arteries through paracrine or vasocrine secretion of bioactive adipokines [14].…”

Section: Relation Between Eat and Cardiovascular Riskmentioning

confidence: 99%

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Association between non-alcoholic fatty liver disease and epicardial adipose tissue volume with cardiometabolic risk in coronary heart disease

Rasmy

Hamed

Demerdash

et al. 2022

Egypt Liver Journal

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Background Regional adiposity has a significant impact on the formation of adverse metabolic and cardiovascular risk profiles. While much of the attention was directed to the importance of intra-abdominal adipose tissue, there were several new investigations about mediastinal and epicardial regions’ visceral adiposity. Our study aimed to determine the association between non-alcoholic fatty liver and increased epicardial adipose tissue mass with coronary artery disease severity. Methods This study was conducted on sixty patients who presented with symptoms of coronary artery disease and attended elective coronary angiography to rule out coronary artery disease. All patients have been subjected to full hepatic profile, noninvasive scoring system such as Fibrosis-4 and non-alcoholic fatty liver disease fibrosis score and abdominal ultrasound for diagnosis of non-alcoholic fatty liver disease and trans-thoracic echocardiography for measurement of average epicardial adipose tissue thickness. Student T test, analysis of variance test, chi-square test, and Fisher’s exact test were used for statistical analysis. Results According to the severity of coronary artery disease, patients with significant coronary stenosis had statistically significant higher degree of hepatic steatosis in abdominal ultrasound (P value < 0.001) while regarding the non-alcoholic fatty liver disease fibrosis score and Fibrosis-4 for non-alcoholic fatty liver disease diagnosis, there was no significance between both groups. Also, the epicardial adipose tissue mean thickness was found to be statistically significantly higher among those with significant coronary stenosis than those without [7.859 ± 0.691 mm versus 5.600 ± 0.386 mm]. Moreover, statistically significant higher epicardial adipose tissue thickness values were found among grade 3 hepatic steatosis than in grades 2, 1, or 0 (P value < 0.001). At a cutoff > 6.1 mm, epicardial adipose tissue thickness was a valuable tool in discrimination between significant and non-significant coronary artery disease with specificity and sensitivity of 100%. Conclusion High epicardial adipose tissue thickness may represent a marker of severity of non-alcoholic fatty liver disease as well as an independent predictor of coronary artery disease risk.

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Section: Relation Between Eat and Cardiovascular Risksupporting

confidence: 59%

Section: Relation Between Eat and Cardiovascular Riskmentioning

confidence: 60%

See 1 more Smart Citation

Association between non-alcoholic fatty liver disease and epicardial adipose tissue volume with cardiometabolic risk in coronary heart disease

Rasmy

Hamed

Demerdash

et al. 2022

Egypt Liver Journal

View full text Add to dashboard Cite

show abstract

“…For instance, one study defined the degree of coronary artery stenosis as mild (<50%), moderate (50–69%), and severe (≥70%) [ 30 ]. In other studies, severe stenosis was only considered when coronary angiography showed stenosis in any vessel exceeding 50% [ 31 , 32 , 33 , 34 ], 70% [ 35 , 36 ], or even 75% [ 37 , 38 , 39 , 40 ]. In this study, we found that when any coronary artery stenosis ≥ 50%, obvious symptoms, including chest pain and chest tightness, are recorded.…”

Section: Methodsmentioning

confidence: 99%

Epicardial Adipose Tissue in Patients with Coronary Artery Disease: A Meta-Analysis

Wang

Chi

Wang

et al. 2022

JCDD

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Objective: The aim of this study is to assess the association between epicardial adipose tissue (EAT) and coronary artery disease (CAD) via meta−analysis. Methods: Specific searches of online databases from January 2000 to May 2022 were conducted. All observational studies evaluating the association between EAT and CAD in PubMed, Web of Science, and the Cochrane Library databases were screened. A meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta−Analyses guidelines (PRISMA). In total, 21 studies encompassing 4975 subjects met the inclusion criteria, including 2377 diagnosed and assigned as the CAD group, while the other 2598 were assigned as the non−CAD group. Subjects in the CAD group were further divided into the severe stenosis group (stenosis ≥ 50%, n = 846) and the mild/moderate stenosis group (stenosis < 50%, n = 577). Results: Both the volume and thickness of EAT in the CAD group were larger compared to the non−CAD group (p < 0.00001). In a subgroup analysis within the CAD group, the severe stenosis group had a larger volume and thickness with respect to EAT when compared to the mild/moderate group (p < 0.001). Conclusions: The enlargement of EAT presented in CAD patients with an association with CAD severity. Although limited by different CAD types and measuring methods for EAT, as well as a smaller sample size, our results suggest that EAT is a novel predictor and a potential therapeutic target for CAD.

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“…EAT имеет эндокринные, паракринные, вазокринные и воспалительные эффекты и связана с метаболическим синдромом, инсулинорезистентностью, ИБС и артериальной гипертензией. Следовательно, измерение толщины EAT приобрело большое значение для выявления рисков прогрессирования ССЗ [37][38][39].…”

Section: передовая статья обзоры литературыunclassified

Obesity as a risk factor for cardiovascular disease: focus on ultrasound

Цыганков¹,

Поликутина

2021

Russ J Cardiol

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For many decades, obesity has been one of the main risk factors for cardiovascular disease. Despite medical advances, the obesity increases contribution to morbidity and mortality from cardiovascular diseases. Numerous anthropometric criteria for obesity are well-studied, simple and inexpensive tools for diagnosing overweight in the population. However, their accuracy is comparatively low. In particular, it is impossible to determine body composition based on these criteria, which is a key point in cardiovascular risk stratification. Despite the relatively short period of ultrasound practice for obesity diagnosis, convincing evidence has already been obtained of their high accuracy and effectiveness in predicting the risk of cardiovascular disease. Given the continuous improvement of ultrasound equipment, the studied criteria should be implemented in routine clinical and research practice. This literature review describes the central parameters used in the ultrasound diagnosis of obesity, their contribution to both conventional risk factors and cardiovascular diseases itself.

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Study of correlation between epicardial fat thickness and severity of coronary artery disease

Cited by 9 publications

References 14 publications

Association between non-alcoholic fatty liver disease and epicardial adipose tissue volume with cardiometabolic risk in coronary heart disease

Association between non-alcoholic fatty liver disease and epicardial adipose tissue volume with cardiometabolic risk in coronary heart disease

Epicardial Adipose Tissue in Patients with Coronary Artery Disease: A Meta-Analysis

Obesity as a risk factor for cardiovascular disease: focus on ultrasound

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