Study of clinical and laboratory profile in alcoholic liver disease with emphasis on renal function

Hegde, Swati; Vishnar, Arun; Ramteke, Girish B.

doi:10.5455/2320-6012.ijrms20150212

Cited by 6 publications

(2 citation statements)

References 15 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study is also close to same geographical area had almost similar results. Majority of the patients with ALD were in the age group of 40-49 years of age(42%) with mean age 43.45 ± 8.65 which corroborates with the study done by Ardhendu Kumar Sen et al 2017, 9 with mean age 45.91±10.34 and Swati Hegda et al 2015 10 where the mean age at presentation was 45.18 years. In the present study anorexia noted in 60% and 86.66%, pain abdomen in 52.72% and 73.33% in noncirrhotic and cirrhotic group of patients respectively.…”

Section: Discussionsupporting

confidence: 84%

Clinical Study on Haematological Profile Abnormalities in Alcoholic Liver Disease Patients in a Tertiary Teaching Hospital in North East India

Ray¹,

Barman²,

Pandit³

2019

jebmh

View full text Add to dashboard Cite

BACKGROUND Alcoholic Liver Disease (ALD) is the cause of about 14 million premature deaths per year worldwide. 1 Alcohol induced liver injury is the most prevalent cause of liver disease and affects 10-20% of the populations worldwide. 2 Chronic alcohol consumption gives rise to various health hazards including liver disease, pancreatitis, central nervous system disorders, peripheral neuropathies and certain forms of cancer. Various haematological and biochemical changes are also seen in a chronic alcoholic patients that further worsen the clinical condition of the patient. The objective of the present study to evaluate clinical and haematological changes that occur in alcoholic liver disease patients and early identification of abnormalities in haematological indices. METHODS This observational, non-interventional hospital-based study was done at North Bengal Medical College and Hospital in the department of General Medicine for a duration of one year from March 2018 to February 2019. Total 200 cases diagnosed alcoholic liver disease patients were included in the study. Clinical history, examination, biochemical and haematological parameters, and USG of abdomen were studied. RESULTS Patients' age ranged from 30 to 60 years and male to female ratio was 2:1. Majority of the patients were in the age group of 41 to 50 years (42%). Anorexia, abdominal pain, jaundice, ascites and splenomegaly were predominant symptoms and signs. Common haematological abnormalities were anaemia, thrombocytopenia and raised PT. Common types of anaemia were normocytic normochromic (58%) and macrocytic (58%). CONCLUSIONS Long duration excessive alcohol ingestion not only leads to acute and chronic liver disorder but also affect haematological indices. Pancytopenia, megaloblastic anaemia, increased PT, INR are some characteristic haematological abnormality in ALD.

show abstract

Section: Discussionsupporting

confidence: 84%

Clinical Study on Haematological Profile Abnormalities in Alcoholic Liver Disease Patients in a Tertiary Teaching Hospital in North East India

Ray¹,

Barman²,

Pandit³

2019

jebmh

View full text Add to dashboard Cite

show abstract

“…In study by Suthar et al, Splenomegaly was seen in 60% cases. 15 In our study, the blood urea was raised (>40 mg/dl) in 35.00% (21 cases) of the patients indicating indirectly towards acute renal injury (49.1% in study by Pathak et al, 37% in study by Hegde et al 19 The creatinine was raised in 19 patients (i.e. 31.67% of the study group) which was comparable with 39.4% in study by Pathak et al, 20% in study by Hegde et al It was observed that 23 patients had GFR <60 ml/min, thus 38.33% of the patients had significantly reduced GFR.…”

Section: Resultssupporting

confidence: 49%

A cross-sectional observational study of lipid profile of cirrhosis of liver patients in a teaching hospital in North Odisha, India

Behera¹

2020

Int J Adv Med

View full text Add to dashboard Cite

Background: Lipids are essential component of biological membranes: also a part of free molecules and metabolic regulators which control cellular function and homeostasis in the body. Liver plays a central role in lipid metabolism. Cardiovascular disease (CVD) risk stratification includes serum lipid profile. In the general population; global prevalence of cirrhosis from autopsy studies ranges from 4.5% to 9.5%. Deaths from cirrhosis have been estimated to increase and would make it as the 12th leading cause of death in 2020. Although several studies have been conducted on dyslipidemia in cirrhotics in developed countries, there is a paucity of data in this regard in India.Methods: This observational study was carried out amongst 60 cirrhosis patients that fulfils the inclusion and exclusion criteria and attended the medicine OPD and admitted in medicine ward of Pandit Raghunath Murmu Medical College and Hospital, Baripada, Dist. Mayurbhanj, Odisha, India from June 2018 to Jan 2019.Results: In our study we had 52 were male and 8 were female. The average age of the patients in the study was 49.62±13.59 yrs. 91.67 % of the patients were alcoholic. Abdominal distension (93.33%) and ascites (81.67%) were most common presenting complaints. Pallor was present in 65.00% cases. Splenomegaly was present in 29 (48.33%) patients of cirrhosis of liver. Renal dysfunction was present in 22 (36.67%) cases. We found decreased HDLC (<40 mg/ Dl) in 34 (56.67%) cases. Hypolipidemia, in particular decreased HDLC level is also an important risk factor for cardiovascular disease and vascular events.Conclusions: From this study we can conclude that lipid abnormalities are commonly seen in patients with liver cirrhosis and screening for the same is important for intervention with appropriate therapy to prevent cardiovascular events. Further studies on lipid abnormalities in these patients and the need for treatment are recommended.

show abstract

Constipation and upper gastrointestinal bleed: Leading precipitating factors of hepatic encephalopathy in Indian cirrhotic patients

Meena

Karthik

et al. 2018

Indian Journal of Medical Specialities

View full text Add to dashboard Cite

Study of clinical and laboratory profile in alcoholic liver disease with emphasis on renal function

Cited by 6 publications

References 15 publications

Clinical Study on Haematological Profile Abnormalities in Alcoholic Liver Disease Patients in a Tertiary Teaching Hospital in North East India

Clinical Study on Haematological Profile Abnormalities in Alcoholic Liver Disease Patients in a Tertiary Teaching Hospital in North East India

A cross-sectional observational study of lipid profile of cirrhosis of liver patients in a teaching hospital in North Odisha, India

Constipation and upper gastrointestinal bleed: Leading precipitating factors of hepatic encephalopathy in Indian cirrhotic patients

Contact Info

Product

Resources

About