Study of biological tolerance of aqueous extract of &lt;i&gt;Sorghum bicolor&lt;/i&gt;

Sènou, Maximin; Tchogou, AP; Assogba, Fidèle; Agossadou, A; Dougnon, Victorien; Agbangnan, Dcp; Laleye, Anatole; Loko, Frédéric

doi:10.4314/jab.v109i1.8

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…This observation was also made with the crude extract of this bark (Agbogba et al, 2019b). Similar observations were also made with the aqueous extract of the leaf sheath of Sorghum bicolor which also showed a hepatoprotective effect (Sènou et al, 2016).…”

Section: Discussionsupporting

confidence: 72%

Ethyl acetate fraction of Psorospermum febrifugum Spach aqueous extract did not exhibit acute or sub-chronic toxicity. Experimental study on Wistar rats

Agbogba¹,

Sènou²,

Tchogou³

et al. 2019

IJB

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Psorospermum febrifugum Spach (Clusiaceae) was a tropical plant whose root bark was used to treat anemia. This work aimed to evaluate the safety of the ethyl acetate fraction of the aqueous extract of this bark. Methods: The ethyl acetate fraction of the extract was administered to Wistar rats in a single dose of 2000 mg / Kg body weight for acute oral toxicity test or daily doses of 200 mg / Kg of body weight during 28 days for sub-chronic oral toxicity test, as recommended by the OECD. At day 0, then at day 14 for the acute phase and day 28 for the sub-chronic phase, the rats were weighed and their blood collected for tests. The activity of transaminases AST and ALT were measured in the liver function tests, blood urea and creatinine were measured for renal function tests and blood leukocytes were counted for the immune balance. These analyzes were supplemented by the histology of the liver, kidneys and spleen, an immune organ. Results: In acute and sub-chronic oral toxicity tests, rat’s weight, liver, kidney and immune balances as well as these organs histology were not affected, suggesting the safety of the extract fraction. Conclusion: The ethyl acetate fraction of the aqueous extract of the root bark of Psorospermum febrifugum did not reveal any acute or sub-chronic oral toxicity. This effect could be related to its richness in flavonoids which have cytoprotective effects. The study of biological tolerance deserves to be continued by the chronic toxicity test and appropriate clinical trials.

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Section: Discussionsupporting

confidence: 72%

Ethyl acetate fraction of Psorospermum febrifugum Spach aqueous extract did not exhibit acute or sub-chronic toxicity. Experimental study on Wistar rats

Agbogba¹,

Sènou²,

Tchogou³

et al. 2019

IJB

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“…The AST and ALT in this current investigation is supported by the near normal liver architecture of the histological result. Similar result was obtained by Sènou et al [3]. Tumeric has been report to have potential to protect the liver against oxidation damage and diseases arising from drug damages (especially by acetaminophen and cancer drugs), infection such as hepatitis A, B, C, E, alcohol damage, fatty liver, cirrhosis cancer has being reported by Singh et al [15].…”

Section: Discussionsupporting

confidence: 83%

“…There is significant (p<0.05) reduction in creatinine level while urea level was slightly higher among the rats fed with the STBH. The Urea level in this present study was however higher than the one reported by Sènou et al [3]. A reverse case was however noticed by Awodele et al, [41] who observed reduction in urea level and no significant reduction in creatinine level with no histological defect.…”

Section: Discussioncontrasting

confidence: 75%

“…Despite the move towards synthetic medicine and use of sophisticated drugs, traditional plant-based remedies still play an important role in the world's medicine [2]. It is estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs [3,4]. Therefore there are considerable economic benefits in the development of indigenous medicine and in the use of medicinal plants for the treatment of various diseases.…”

Section: Introductionmentioning

confidence: 99%

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Effects of a formulated herbal mixture from Sorghum bicolor L., Curcuma longa L, Bridelia ferruginea B. in honey on weight, biochemical profile and hematological indices of apparently healthy Wister rats

Ojo¹,

TT²,

AO³

et al. 2022

Int. J. Front. Life Sci. Res.

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Plants and plant derived products have been a source of alternate therapy for ages. This is because of availability and effectiveness in managing a wide range of illnesses. This study was carried out to assess the effects of a formulated herbal mixture made from Sorghum bicolor L., Curcuma longa L, Bridelia ferruginea B. and honey (STBH) on weight, biochemical parameters, hematological profile and histological effect on key organs of apparently healthy Wistar rats. The plant materials and honey used were sourced locally. The herbal mixture (STBH) was formulated from Sorghum bicolor L., (7.74g/kg body weight), Tumeric (2.4 g/kg body weight), Honey (2.5 g/kg body weight) and Bridelia ferruginea (0.4 g/kg body weight) to form 13 g/kg body weight (1.3 mg/g) of the mixture. A total of 40, apparently healthy male Wistar rats, 6-8weeks old with average initial body weight of 75 g was used. The rats were randomly grouped into four groups. The first 3 groups A, B and C (n=12 each) were orally administered the herbal mixture at dosage of 0.65mg/g, 1.3mg/g and 2.6mg/g of rat weight respectively for 28 days in order to determine the safe dose while the last group D (n=4) as control. At the end of every week, the weights of the rats was measured, while the blood samples of 3 rats per treatment group and one from control group which were randomly selected were subjected to Biochemical and Haematological assays and their organs (Kidney, Heart and Liver) were harvested for histological examination following standard methods. The results revealed weight gain among the rat fed with STBH compared to the control rats with group A having the highest percentage weight gain (50.55%). Haematological results showed significant (p<0.05) improvement in pack cell volume (PCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and mean corpuscular volume (MCV) of the rats. Moreover, significant (p<0.05) immunostimulatory effect was observed in group A rats compared to groups B, C and D rats. AST and ALT were considerably lower in group A rats when compared to the control, unlike the increase in values at higher dosages (groups B and C rats) though the increase was not significant (p>0.05) . Urea level was fairly high in groups B and C rats, while it reduced in group A rats as compared to the control group. Histology of the liver, heart and kidney of the rats fed with STBH showed near normal architecture with no significant deviations from the control. These suggest that STBH is safe, improves PCV, has immunostimulatory potential and also shows ability to maintain the normal architecture of the liver, kidney and the heart.

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Unleashing the Potential of Medicinal Plants in Benin: Assessing the Status of Research and the Need for Enhanced Practices

Agbodjento

Lègba

Dougnon

et al. 2023

Plants

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Medicinal plants play a crucial role in the primary health care of the population in developing countries such as Benin. The national universities of Benin conduct research on the pharmacological, toxicological, and phytochemical properties of these plants, but the resulting knowledge often does not lead to the development of phytomedicines for the improvement of public health. This study aims to assess the current status of research on medicinal plants in Benin. A literature review was conducted using various search engines, and the collected data was analyzed. The results indicate that research on the biological properties of medicinal plants is still in its early stages, with limited and inadequate methodological approaches. These limitations highlight the urgent need to enhance research practices and facilitate the development of effective and safe phytomedicines.

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Study of biological tolerance of aqueous extract of <i>Sorghum bicolor</i>

Cited by 5 publications

References 11 publications

Ethyl acetate fraction of Psorospermum febrifugum Spach aqueous extract did not exhibit acute or sub-chronic toxicity. Experimental study on Wistar rats

Ethyl acetate fraction of Psorospermum febrifugum Spach aqueous extract did not exhibit acute or sub-chronic toxicity. Experimental study on Wistar rats

Effects of a formulated herbal mixture from Sorghum bicolor L., Curcuma longa L, Bridelia ferruginea B. in honey on weight, biochemical profile and hematological indices of apparently healthy Wister rats

Unleashing the Potential of Medicinal Plants in Benin: Assessing the Status of Research and the Need for Enhanced Practices

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