Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression

Gakhar, Harinder; Dhillon, Amandeep Kaur; Blackwell, Jem; Hussain, Kesar; Bommireddy, R; Klézl, Zdeněk; Williams, John P.

doi:10.1007/s00586-015-4050-7

Cited by 34 publications

(25 citation statements)

References 31 publications

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“…Our results provide new, clinically relevant information to the existing literature regarding the role of sarcopenia on predicting early postoperative outcomes. Gakhar et al and Zhakaria et al have previously reported decreased survival with lower psoas size in patients with spinal metastasis [23,45]. In contrast to our study, Zakaria et al did not examine patients who underwent surgical intervention, but rather those treated with radiation therapy only.…”

Section: Discussioncontrasting

confidence: 59%

“…For each patient, we calculated the ratio of the sum of the left and right psoas muscle area divided by the area of the L3 vertebral body (L3-TPA/VBA) as depicted in Figure 1. This measurement technique was previously shown to have good inter-rater reliability [23]. The timedependent changes in muscle mass in oncologic patients are a well-known phenomenon.…”

Section: Patient and Surgical Datamentioning

confidence: 98%

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Sarcopenia, but not frailty, predicts early mortality and adverse events after emergent surgery for metastatic disease of the spine

Bourassa-Moreau

Versteeg²,

Moskven

et al. 2020

The Spine Journal

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Section: Discussioncontrasting

confidence: 59%

Section: Patient and Surgical Datamentioning

confidence: 98%

Sarcopenia, but not frailty, predicts early mortality and adverse events after emergent surgery for metastatic disease of the spine

Bourassa-Moreau

Versteeg²,

Moskven

et al. 2020

The Spine Journal

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“…MRI is the most accurate method for determining muscle mass [13]. In all previous studies that diagnosed sarcopenia using CT or MRI, cutoff points were derived arbitrarily, as the lowest tertile or quartile of muscle area [14][15][16][17][18]. In this study, the reference range of TPA for Indian men and women was calculated from records of clinically and radiologically normal adults.…”

Section: Discussionmentioning

confidence: 99%

Does Sarcopenia Increase the Risk for Fresh Vertebral Fragility Fractures?: A Case-Control Study

et al. 2020

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Sarcopenia is an age associated condition characterized by decrease in muscle mass, strength, and physical performance. We aimed to investigate whether sarcopenia increased the risk of vertebral fragility fractures among the elderly. Overview of Literature: Initial reports on sarcopenia suggest its contribution to the development of vertebral fragility fractures. However, recent studies showed contradictory findings. Methods: Fifty-one consecutive patients with vertebral fragility fractures and matched controls without fractures were evaluated for sarcopenia, T-score, body mass index, and presence of preexisting vertebral fractures. Sarcopenia was diagnosed as total psoas cross-sectional area (TPA) 2 standard deviations below normative value from normal young adults and decreased handgrip strength (26 kg for men and 18 kg for women). Univariate and multivariate analyses were performed using the fresh fracture occurrence as the dependent variable. Results: Sarcopenia was confirmed in 29.4% and 7.8% of cases and controls (p=0.005), respectively; 56.8% and 13.7% of cases and controls had previous vertebral fractures. Sarcopenia prevalence was greater among those with previous fractures (38% vs. 7.6%; odds ratio, 7.76; p<0.001). TPA was lower among the cases (1,278 mm 2 vs. 1,569 mm 2 , p=0.001) and those with previous fractures (1,168 mm 2 vs. 1,563 mm 2 , p<0.001). Handgrip strength was greater among those without previous fractures (19.6 kg vs. 16.3 kg, p=0.05). In multivariate analysis, sarcopenia was not identified as a significant predictor of fresh fractures whereas previous fractures and lower T-score were found to be significant. Conclusions: Sarcopenia is not an independent risk factor for fresh vertebral fragility fractures in the elderly.

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“…Therefore, the application is limited to individuals who have had CT scans completed as part of their medical treatment. To date, most published research using CT scans for body composition assessment is retrospective and has been conducted in cancer populations, 12 – 16 but recent work has extended this to other clinical populations 17 – 23 …”

Section: Ctmentioning

confidence: 99%

“…Most studies that measure body composition with CT analysis attempt to identify the prognostic ability of skeletal muscle cross‐sectional area, or changes in skeletal muscle attenuation values (ie, HUs) at a single time point 10 , 12 – 21 , 32 – 35 . In general, skeletal muscle cross‐sectional area and muscle attenuation are often demonstrated to have strong prognostic values—with lower cross‐sectional area or reduced attenuation values being associated with worse outcomes.…”

Section: Ctmentioning

confidence: 99%

The Use of Technology for Estimating Body Composition

et al. 2016

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Assessment of body composition, both at single time points and longitudinally, is particularly important in clinical nutrition practice. It provides a means for the clinician to characterize nutrition status at a single time point, aiding in the identification and diagnosis of malnutrition, and to monitor changes over time by providing real-time information on the adequacy of nutrition interventions. Objective body composition measurement tools are available clinically but are often underused in nutrition care, particularly in the United States. This is, in part, due to a number of factors concerning their use in a clinical context: cost and accessibility of equipment, as well as interpretability of the results. This article focuses on the factors influencing interpretation of results in a clinical setting. Body composition assessment, regardless of the method, is inherently limited by its indirect nature. Therefore, an understanding of the strengths and limitations of any method is essential for meaningful interpretation of its results. This review provides an overview of body composition technologies available clinically (computed tomography, dual-energy x-ray absorptiometry, bioimpedance, ultrasound) and discusses the strengths and limitations of each device.

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Study investigating the role of skeletal muscle mass estimation in metastatic spinal cord compression

Abstract: Death within 1 year in individuals with spinal metastases is related to lean muscle mass at presentation. Assessment of lean muscle mass may inform decision to operate in patients with spinal metastases.

Cited by 34 publications

References 31 publications

Sarcopenia, but not frailty, predicts early mortality and adverse events after emergent surgery for metastatic disease of the spine

Sarcopenia, but not frailty, predicts early mortality and adverse events after emergent surgery for metastatic disease of the spine

Does Sarcopenia Increase the Risk for Fresh Vertebral Fragility Fractures?: A Case-Control Study

The Use of Technology for Estimating Body Composition

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