Studies on wild house mice VI: Differential effects of the Y chromosome on intermale aggression

Selective breeding for isolation-induced intermale aggression in mice: Associated responses and environmental influences

“…The results showed that although exposure to testosterone had a slight aggression-enhancing effect on TNA males, the difference between the experimental and control (injected with peanut oil) groups did not reach significant levels. The literature on the involvement of the Y chromosome has been somewhat inconsistent, and evidence has been presented which suggests that in some strains and lines of mice the genes that influence aggressive behavior might be situated on the Y chromosome (Maxson, 1981;Maxson et al, 1983;van Oortmerssen and Sluyter, 1994;Sluyter et al, 1994). These results are at least partially in line with the findings of Compaan and her co-workers (1992), who used two selection lines of wild house mice.…”

Selective breeding for isolation-induced intermale aggression in mice: Associated responses and environmental influences

“…The results showed that although exposure to testosterone had a slight aggression-enhancing effect on TNA males, the difference between the experimental and control (injected with peanut oil) groups did not reach significant levels. The literature on the involvement of the Y chromosome has been somewhat inconsistent, and evidence has been presented which suggests that in some strains and lines of mice the genes that influence aggressive behavior might be situated on the Y chromosome (Maxson, 1981;Maxson et al, 1983;van Oortmerssen and Sluyter, 1994;Sluyter et al, 1994). These results are at least partially in line with the findings of Compaan and her co-workers (1992), who used two selection lines of wild house mice.…”

Sex differences in genetic mechanisms for mammalian brain and behavior

“…There arc Y chromosome effects on brain and behavior of male mice. They include effects on hippocampal weight (23), asymmetry in hippocampal size (23), hippocampal mossy fiber distribution (24), whole brain levels of serotonin (25) and dynorphin (26), open Held behavior (27), circadian rhythms (28), coping strategies (29), apomorphinc-induced stereotypy (30), copulatory behaviors (31,32), aggressive behavior (33)(34)(35), and discrimination learning (23). Reciprocal Fls, segregating populations, and congenic strains have been used in these studies.…”

Electrostatic interactions with histone tails may bend linker DNA in chromatin

“…Both genetic and environmental factors contribute to the manifestation of aggression in male house mice. Genetic studies have suggested that at least two sex‐linked and several autosomal loci are associated with variation in fighting behavior [Brodkin et al, 2002; Roubertoux et al, 2005; Selmanoff et al, 1975; Sluyter et al, 1994]. At the individual level, the outcome of male aggression is modulated by a variety of non‐genetic factors, such as hormonal induction (linked to fetal intrauterine position [Ryan and Vandenbergh, 2002]), hormonal and neurochemical changes [Caramaschi et al, 2008a, b; Natarajan et al, 2009a], pre‐ and postnatal maternal effects [Sluyter et al, 1995], and social environment after weaning [e.g.…”

Selective breeding for isolation-induced intermale aggression in mice: Associated responses and environmental influences

“…The results showed that although exposure to testosterone had a slight aggression-enhancing effect on TNA males, the difference between the experimental and control (injected with peanut oil) groups did not reach significant levels. The literature on the involvement of the Y chromosome has been somewhat inconsistent, and evidence has been presented which suggests that in some strains and lines of mice the genes that influence aggressive behavior might be situated on the Y chromosome (Maxson, 1981;Maxson et al, 1983;van Oortmerssen and Sluyter, 1994;Sluyter et al, 1994). These results are at least partially in line with the findings of Compaan and her co-workers (1992), who used two selection lines of wild house mice.…”

Sex differences in genetic mechanisms for mammalian brain and behavior

“…There arc Y chromosome effects on brain and behavior of male mice. They include effects on hippocampal weight (23), asymmetry in hippocampal size (23), hippocampal mossy fiber distribution (24), whole brain levels of serotonin (25) and dynorphin (26), open Held behavior (27), circadian rhythms (28), coping strategies (29), apomorphinc-induced stereotypy (30), copulatory behaviors (31,32), aggressive behavior (33)(34)(35), and discrimination learning (23). Reciprocal Fls, segregating populations, and congenic strains have been used in these studies.…”

Electrostatic interactions with histone tails may bend linker DNA in chromatin

“…Both genetic and environmental factors contribute to the manifestation of aggression in male house mice. Genetic studies have suggested that at least two sex‐linked and several autosomal loci are associated with variation in fighting behavior [Brodkin et al, 2002; Roubertoux et al, 2005; Selmanoff et al, 1975; Sluyter et al, 1994]. At the individual level, the outcome of male aggression is modulated by a variety of non‐genetic factors, such as hormonal induction (linked to fetal intrauterine position [Ryan and Vandenbergh, 2002]), hormonal and neurochemical changes [Caramaschi et al, 2008a, b; Natarajan et al, 2009a], pre‐ and postnatal maternal effects [Sluyter et al, 1995], and social environment after weaning [e.g.…”

Selective breeding for isolation-induced intermale aggression in mice: Associated responses and environmental influences

“…The results showed that although exposure to testosterone had a slight aggression-enhancing effect on TNA males, the difference between the experimental and control (injected with peanut oil) groups did not reach significant levels. The literature on the involvement of the Y chromosome has been somewhat inconsistent, and evidence has been presented which suggests that in some strains and lines of mice the genes that influence aggressive behavior might be situated on the Y chromosome (Maxson, 1981;Maxson et al, 1983;van Oortmerssen and Sluyter, 1994;Sluyter et al, 1994). These results are at least partially in line with the findings of Compaan and her co-workers (1992), who used two selection lines of wild house mice.…”

Sex differences in genetic mechanisms for mammalian brain and behavior

“…There arc Y chromosome effects on brain and behavior of male mice. They include effects on hippocampal weight (23), asymmetry in hippocampal size (23), hippocampal mossy fiber distribution (24), whole brain levels of serotonin (25) and dynorphin (26), open Held behavior (27), circadian rhythms (28), coping strategies (29), apomorphinc-induced stereotypy (30), copulatory behaviors (31,32), aggressive behavior (33)(34)(35), and discrimination learning (23). Reciprocal Fls, segregating populations, and congenic strains have been used in these studies.…”

Electrostatic interactions with histone tails may bend linker DNA in chromatin

“…Both genetic and environmental factors contribute to the manifestation of aggression in male house mice. Genetic studies have suggested that at least two sex‐linked and several autosomal loci are associated with variation in fighting behavior [Brodkin et al, 2002; Roubertoux et al, 2005; Selmanoff et al, 1975; Sluyter et al, 1994]. At the individual level, the outcome of male aggression is modulated by a variety of non‐genetic factors, such as hormonal induction (linked to fetal intrauterine position [Ryan and Vandenbergh, 2002]), hormonal and neurochemical changes [Caramaschi et al, 2008a, b; Natarajan et al, 2009a], pre‐ and postnatal maternal effects [Sluyter et al, 1995], and social environment after weaning [e.g.…”