Studies on vitamin D (calciferol) and its analogs. 10. Side-chain analogs of 25-hydroxyvitamin D3

Rl, Johnson; Sc, Carey; Norman, A. W.; Wh, Okamura

doi:10.1021/jm00211a002

Cited by 18 publications

(1 citation statement)

References 4 publications

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“…Active vitamin D analogues stimulate calcium absorption from intestine 18 , 19 and are frequently used to block hypocalcemia in patients undergoing treatment with strong anti-bone resorptive agents 20 , 21 . These analogues reportedly enhance the ability of bisphosphonates to elevate bone mass in osteoporosis patients 22 .…”

Section: Introductionmentioning

confidence: 99%

Osteonecrosis development by tooth extraction in zoledronate treated mice is inhibited by active vitamin D analogues, anti-inflammatory agents or antibiotics

Soma

Iwasaki

Sato

et al. 2022

Sci Rep

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Invasive dental treatment such as tooth extraction following treatment with strong anti-bone resorptive agents, including bisphosphonates and denosumab, reportedly promotes osteonecrosis of the jaw (ONJ) at the extraction site, but strategies to prevent ONJ remain unclear. Here we show that in mice, administration of either active vitamin D analogues, antibiotics or anti-inflammatory agents can prevent ONJ development induced by tooth extraction during treatment with the bisphosphonate zoledronate. Specifically, tooth extraction during treatment with zoledronate induced osteonecrosis in mice, but administration of either 1,25(OH)2D3 or ED71, both active vitamin D analogues, significantly antagonized osteonecrosis development, even under continuous zoledronate treatment. 1,25(OH)2D3 or ED71 administration also significantly inhibited osteocyte apoptosis induced by tooth extraction and bisphosphonate treatment. Administration of either active vitamin D analogue significantly inhibited elevation of serum inflammatory cytokine levels in mice in response to injection of lipopolysaccharide, an infection mimetic. Furthermore, administration of either anti-inflammatory or antibiotic reagents significantly blocked ONJ development following tooth extraction and zoledronate treatment. These findings suggest that administration of active vitamin D, anti-inflammatory agents or antibiotics could prevent ONJ development induced by tooth extraction in patients treated with zoledronate.

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