Studies on the Production of High Radioiodine Uptake Goiter with Propylthiouracil

Greer, Monte A.; Whallon, Joanne H.; Yamada, Takashi; Iino, Shiro

doi:10.1210/endo-70-5-650

Cited by 6 publications

(3 citation statements)

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“…It is quite possible that goitrin almost never inhibits the monoiodination of tyrosine, but it inhibits the coupling of MIT to synthesize DIT. These results in the distribution of iodinated substances in thyroid of goitrinfed chicks are similar to the reports by lino et al (1961) and Greer et al (1962) on rats that the monoiodination of tyrosine may be increased as the production of other iodinated amino acids (DIT, T 3 and T 4 ) is being reduced by administration of small doses of PTU that are used customarily to induce goiter. However, the goitrin used in our study produced larger goiters with a high thyroidal uptake of 131 I than those in their reports.…”

Section: Resultssupporting

confidence: 90%

“…Increased thyroid 131 I uptake in goitrinfed chicks obtained from our previous experiment is similar to high radioiodine uptake goiter which results from a small doses of PTU or MTU in the rats (Slingerland et al, 1959;Greer et al, 1962;and Yamada and Shichijo, 1962), however, goitrin administered chicks had larger thy-roid (3 to 4 times of control) in comparison with latter reports (1 to 1.3 times of control).…”

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confidence: 82%

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Effects of (-)-5-Vinyl-2-Oxazolidinethione on the Radioiodine Metabolism in Growing Chicks

1969

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Section: Resultssupporting

confidence: 90%

supporting

confidence: 82%

Effects of (-)-5-Vinyl-2-Oxazolidinethione on the Radioiodine Metabolism in Growing Chicks

1969

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“…This effect has been described previously by Slingerland et al (1959). Later, Greer, Whallon, Yamada & lino (1962) concluded that the effect was spurious since a significant increase in thyroid size was always associated with a decreased uptake of radioactive iodine. However, their data in rats maintained on a low iodine diet (0-07 fig.¡g.…”

Section: Discussionsupporting

confidence: 67%

The Effect of Prolonged Feeding of Goitrogens on Thyroid Function in Rats

Broadhead¹,

Pearson²,

Wilson³

1965

Journal of Endocrinology

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Graded doses of propylthiouracil, carbimazole, sulphadiazine, potassium perchlorate and potassium thiocyanate were fed to groups of rats under standardized conditions for 2 months. The rats were given 131I 24 hr. before they were killed, and the thyroid weight, the proportions of labelled iodoaminoacids, and the thyroidal iodine content were determined. All the goitrogens produced increase in thyroid size, reduction of thyroidal iodine content, and an elevation of the monoiodotyrosine : di-iodotyrosine (MIT : DIT) ratio. The tri-iodothyronine : thyroxine (T3 : T4) ratio was usually increased. Irrespective of the antithyroid compound used, there was a close correlation between the decrease in thyroidal iodine content and the rise in the MIT:DIT ratio.In further experiments, either thyroid stimulating hormone (TSH) or thyroxine were injected s.c. twice daily for 5 days. TSH decreased the MIT:DIT ratio and increased the amount of labelled T3. Thyroxine increased the MIT : DIT ratio and decreased the amount of T4.It is suggested that when goitrogens were administered for a prolonged period, the pattern of 131I-labelling of iodoaminoacids was dependent on a balance between inhibition of synthesis caused by the goitrogen and stimulation due to TSH. There was increased production of the physiologically more economical T3 in an attempt to compensate for decreased thyroxine formation.

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Analysis of the regulation of basal metabolism in dependence on environmental factors and body weight

Scharf

1966

Helgolander Wiss. Meeresunters

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Analysis of the regulation of basal metabolism in dependence on environmental factors and body weight. In large-scale experiments carried out over a period of about 15 years, white rats were subjected to chronic treatment with antithyroid drugs, substances counteracting LANGERHANS' islets (mostly alloxan), hormone fragments, and native hormones respectively. The O~-consumption (mostly in an artificial microclimate) was measured in each test. The test batches were either gradually diminished by killing the animals one after another, to yield histological series in chronological order, or a whole batch was pooled together at the end of a test. In all experiments a relationship could be established between O2-consumption and the histology" "(histochemical tests included) of liver and endocrine glands. In a recent experiment, moreover, serum enzymes and the level of blood sugar were determined; a chromatographic analysis of thyroid hormone fractions and blood cells-counts were made. Combining these methods led to numerous variables suitable for numerical treatment. Besides a treatment of the data by elementary methods (variance analysis, t-test, U-test, linear 2-dimensional regression analysis), multidimensional space models, employing traditional and novel calculi were used. The regression equations in 23-dimensional statements were linear, quadratic and cubic. In a concordance analysis 25 variables were carried along. To develop a satisfactory theory, the coefficients of the differential equations underlying the material were determined by means of an approximation method suited for random samples subject to variance. For solution, integrals, polynomials of e-functions, using mostly the regression calculus in two steps were sought. The oscillations caused by environmental factors were extracted as the differences between the function values of the optimal particular and real integral and the empirical ordinates. This isolated swinging remainder was analysed following FouriEr. The spectra or the oscillation portions themselves were brought into functional relation with one another by means of functional operators always controlled by hetero-and auto-correlation. The model of the control of metaboIism by the diencephalicpituitary-thyroid-system could thus be reduced to an n-dimensional linear space model, which, however, is not quite satisfactory.

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Studies on the Production of High Radioiodine Uptake Goiter with Propylthiouracil

Cited by 6 publications

References 0 publications

Effects of (-)-5-Vinyl-2-Oxazolidinethione on the Radioiodine Metabolism in Growing Chicks

Effects of (-)-5-Vinyl-2-Oxazolidinethione on the Radioiodine Metabolism in Growing Chicks

The Effect of Prolonged Feeding of Goitrogens on Thyroid Function in Rats

Analysis of the regulation of basal metabolism in dependence on environmental factors and body weight

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