Studies on the metabolic fate of sucrose esters in rats

Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier sucrose fatty acid ester

“…Earlier workers also tried out to enhance the dissolution of indomethacin by SD technique, El-Badry et al prepared SD using PEG4000 and Gelucire 50/13 using hot melting method, results have shown that more amount of carrier was required and also 90 min was required for complete release of drug [18]. The capability to enhance or increase the drug release and bioavailability of the insoluble drug by SFE 1815 depends upon the common factors like excellent wettability, which could be observed clearly from the solid dispersion since it rapidly left the surface and was dispersed in the bulk of the dissolution medium which markedly increased indomethacin solubility and also specific features like (i) HLB value – higher the HLB value greater is the ability to enhance (ii) length of fatty acid chain - shorter fatty acid increases the release more than the longer fatty acids [19] (iii) number of carbon atoms in the fatty acid chain [19] (v) proportion of monoesters –higher the proportion of monoesters higher is the hydrophilicity of the surfactant [12,20,21]. The main reason for better drug release of SD using SFE 1815 is the HLB value which is 15 and the number of monoesters (70%) in the ester composition of the carrier.…”

Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier sucrose fatty acid ester

“…Earlier workers also tried out to enhance the dissolution of indomethacin by SD technique, El-Badry et al prepared SD using PEG4000 and Gelucire 50/13 using hot melting method, results have shown that more amount of carrier was required and also 90 min was required for complete release of drug [18]. The capability to enhance or increase the drug release and bioavailability of the insoluble drug by SFE 1815 depends upon the common factors like excellent wettability, which could be observed clearly from the solid dispersion since it rapidly left the surface and was dispersed in the bulk of the dissolution medium which markedly increased indomethacin solubility and also specific features like (i) HLB value – higher the HLB value greater is the ability to enhance (ii) length of fatty acid chain - shorter fatty acid increases the release more than the longer fatty acids [19] (iii) number of carbon atoms in the fatty acid chain [19] (v) proportion of monoesters –higher the proportion of monoesters higher is the hydrophilicity of the surfactant [12,20,21]. The main reason for better drug release of SD using SFE 1815 is the HLB value which is 15 and the number of monoesters (70%) in the ester composition of the carrier.…”

Sucrose Esters Increase Drug Penetration, But Do Not Inhibit P‐Glycoprotein in Caco‐2 Intestinal Epithelial Cells

“…In contrast to cell culture works, sucrose esters did not damage palatal and buccal pork tissues . Animal studies indicate that sucrose fatty acid esters are hydrolyzed by intestinal enzymes into sucrose and fatty acids and that their metabolites are not toxic . In addition, sucrose esters are chemically hydrolyzed under acidic or basic conditions and can be disintegrated by bacterial lipases .…”

Sucrose fatty acid esters suppress pancreatic secretion accompanied by peptide YY release in pancreatico‐biliary diverted rats

“…Sucrose esters are resistant to lipase; however, previous reports showed that some sucrose esters can be digested in the intestine (Shigeoka et al 1984; Noker et al 1997). If the suppression depends on fatty acids released from sucrose esters, inhibition of lipase activity should reverse the sucrose ester‐induced inhibition of pancreatic secretion.…”

Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier sucrose fatty acid ester

“…Earlier workers also tried out to enhance the dissolution of indomethacin by SD technique, El-Badry et al prepared SD using PEG4000 and Gelucire 50/13 using hot melting method, results have shown that more amount of carrier was required and also 90 min was required for complete release of drug [18]. The capability to enhance or increase the drug release and bioavailability of the insoluble drug by SFE 1815 depends upon the common factors like excellent wettability, which could be observed clearly from the solid dispersion since it rapidly left the surface and was dispersed in the bulk of the dissolution medium which markedly increased indomethacin solubility and also specific features like (i) HLB value – higher the HLB value greater is the ability to enhance (ii) length of fatty acid chain - shorter fatty acid increases the release more than the longer fatty acids [19] (iii) number of carbon atoms in the fatty acid chain [19] (v) proportion of monoesters –higher the proportion of monoesters higher is the hydrophilicity of the surfactant [12,20,21]. The main reason for better drug release of SD using SFE 1815 is the HLB value which is 15 and the number of monoesters (70%) in the ester composition of the carrier.…”

Sucrose Esters Increase Drug Penetration, But Do Not Inhibit P‐Glycoprotein in Caco‐2 Intestinal Epithelial Cells

“…In contrast to cell culture works, sucrose esters did not damage palatal and buccal pork tissues . Animal studies indicate that sucrose fatty acid esters are hydrolyzed by intestinal enzymes into sucrose and fatty acids and that their metabolites are not toxic . In addition, sucrose esters are chemically hydrolyzed under acidic or basic conditions and can be disintegrated by bacterial lipases .…”

Sucrose fatty acid esters suppress pancreatic secretion accompanied by peptide YY release in pancreatico‐biliary diverted rats

“…Sucrose esters are resistant to lipase; however, previous reports showed that some sucrose esters can be digested in the intestine (Shigeoka et al 1984; Noker et al 1997). If the suppression depends on fatty acids released from sucrose esters, inhibition of lipase activity should reverse the sucrose ester‐induced inhibition of pancreatic secretion.…”

Investigation on in vitro dissolution rate enhancement of indomethacin by using a novel carrier sucrose fatty acid ester

“…Earlier workers also tried out to enhance the dissolution of indomethacin by SD technique, El-Badry et al prepared SD using PEG4000 and Gelucire 50/13 using hot melting method, results have shown that more amount of carrier was required and also 90 min was required for complete release of drug [18]. The capability to enhance or increase the drug release and bioavailability of the insoluble drug by SFE 1815 depends upon the common factors like excellent wettability, which could be observed clearly from the solid dispersion since it rapidly left the surface and was dispersed in the bulk of the dissolution medium which markedly increased indomethacin solubility and also specific features like (i) HLB value – higher the HLB value greater is the ability to enhance (ii) length of fatty acid chain - shorter fatty acid increases the release more than the longer fatty acids [19] (iii) number of carbon atoms in the fatty acid chain [19] (v) proportion of monoesters –higher the proportion of monoesters higher is the hydrophilicity of the surfactant [12,20,21]. The main reason for better drug release of SD using SFE 1815 is the HLB value which is 15 and the number of monoesters (70%) in the ester composition of the carrier.…”

Sucrose Esters Increase Drug Penetration, But Do Not Inhibit P‐Glycoprotein in Caco‐2 Intestinal Epithelial Cells

“…In contrast to cell culture works, sucrose esters did not damage palatal and buccal pork tissues . Animal studies indicate that sucrose fatty acid esters are hydrolyzed by intestinal enzymes into sucrose and fatty acids and that their metabolites are not toxic . In addition, sucrose esters are chemically hydrolyzed under acidic or basic conditions and can be disintegrated by bacterial lipases .…”

Sucrose fatty acid esters suppress pancreatic secretion accompanied by peptide YY release in pancreatico‐biliary diverted rats

“…Sucrose esters are resistant to lipase; however, previous reports showed that some sucrose esters can be digested in the intestine (Shigeoka et al 1984; Noker et al 1997). If the suppression depends on fatty acids released from sucrose esters, inhibition of lipase activity should reverse the sucrose ester‐induced inhibition of pancreatic secretion.…”